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20,252 grants found
Showing 17,921 – 17,940 of 20,252 grants
Multi-scale modeling of glioma for the prediction of treatment response, treatment monitoring and treatment allocation
Project summary Computational multi-scale modeling is a growing area of research that aims to link whole slide images and radiographic iamges with multi-omics molecular profiles of...
Repurposing Leflunomide to Delay Progression of Smoldering Multiple Myeloma in African Americans
PROJECT SUMMARY Smoldering multiple myeloma (SMM) is an asymptomatic precursor of active multiple myeloma (MM), and 50 percent of patients meeting criteria for high-risk disease wi...
Drug eluting injectable biomaterials for next generation chemoembolization
Abstract Hepatocellular carcinoma (HCC), the most common type of liver cancer, is a major worldwide public health concern because it is often detected at advanced stages where trea...
Identifying therapeutic pathways targeting medulloblastoma-immune cell interactions
SUMMARY We propose developing a systems-biology approach to understand interactions between tumor and immune cells and their clinical implications. Our work will focus on medullobl...
Proteolysis-targeting chimera against BCL-XL inhibits breast cancer metastasis
Project Summary-Abstract Metastasis is the major cause of BrCa death. Most women with metastatic BrCa (stage IV) are treated mainly with systemic therapy such as hormone therapy (f...
Applying deep learning to predict T cell receptor binding specificity of neoantigens and response to checkpoint inhibitors
Project Summary Background: In-depth study of neoantigens will promote our knowledge of the fundamental mechanisms of basic immunology and immune-related disease processes, such as...
Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer
Project Summary/Abstract The ultimate goal of this mPI proposal is to address a fundamental gap in knowledge on the role of acetyl-CoA metabolic reprogramming in regulating cyclin...
PROTEAN-CR: Proteomics Toolkit for Ensemble Analysis in Cancer Research
Project Summary Understanding protein–ligand molecular interactions is fundamental to understanding the role of proteins in complex diseases such as cancer. For instance, there is...
Cancer-prone cell states of the fallopian tubal epithelium
Project Summary Ovarian/extra-uterine high-grade serous carcinoma (HGSC) is the most common and aggressive type of ovarian cancer. It often has no symptoms at early stages and over...
Immunity to commensal papillomaviruses for cancer therapy
Project Summary/Abstract: Research in the field of microbiome has largely focused on the beneficial effects of commensal bacteria in regulating tissue homeostasis and the immune re...
Dual function of HSP70 in cytoprotection of tumor cells and generation of permissive microenvironment
It has been widely accepted that distinct epithelial to mesenchymal transition (EMT) phenotype and cancer stem cell (CSC) properties as well as the immunosuppressive tumor microenv...
Chromosome 1q ceRNAs in Melanoma Progression and Metastasis
PROJECT SUMMARY Metastasis is the main cause of deaths related to malignant melanoma. Studies over the last decade have revealed that the metastatic process is not primarily driven...
Support of the North American Association of Central Cancer Registries, Inc. (NAACCR) Annual Scientific Conference
NAACCR Annual Scientific Conference Project Summary R13 20-207 Cancer surveillance data are the lynchpin of the cancer data ecosystem. Only through the collection of accurate, stan...
Stat4Onc Annual Symposium
Project Summary/Abstract Cancer is the 2nd leading cause of death in US. Statistical designs and data analytics approaches are instrumental in recent development of more effective...
Development of Rationally Designed Cancer Vaccines Using Protein-like Polymers (PLPs)
PROJECT SUMMARY The utilization of tumor antigens, which are antigenic peptides expressed in cancer cells as a result of random somatic mutations, for the development of patient-sp...
Multimodality X-ray transmission and diffraction scanner for molecular analysis of cancer specimens
ABSTRACTCancer research using biospecimens requires the analysis of samples with a large range of sizes (sub-mm to cm) and molecular composition over a wide range of length scales....
Microbiota, Metabolites, and Colon Neoplasia
Project Summary The human diet can positively or negatively impact cancer incidence, with plant-derived compounds – such as polyphenols – often exhibiting antioxidant cancer-preven...
Reduction of Tumor-Positive Margins in Oncology Surgery
Project Abstract Approximately 80% of early stage head and neck tumors undergo surgery of curative intent at some point in their treatment course. The success of this oncologic sur...
SEER CORE INFRASTRUCTURE SUPPORT
The purpose of the National Cancer Institute (NCI) Surveillance Epidemiology and End Results (SEER) Program is to assemble and report annual estimates of cancer statistics that per...
CXCL5/CXCR2 axis as a therapeutic vulnerability of breast cancer metastasis to bone
PROJECT SUMMARY/ABSTRACT The majority of breast cancers express estrogen receptor a (ER+), a molecule that typically promotes cell proliferation when activated by its ligand estrog...