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20,252 grants found
Showing 17,901 – 17,920 of 20,252 grants
Project 4: The BRCA Network in Medulloblastoma Responses to Replication Stress
The BRCA Network in Medulloblastoma Responses to Replication Stress (Project-4) Abstract: BRCA1 and BRCA2 are critical genes for the repair of DNA strand breaks (DSB) via homologou...
SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer
Head and neck cancers (HNCs) account for nearly 3% of all cancers in the U.S. and most commonly affect aging individuals. While chemo-radiotherapy is the standard treatment approac...
Applying pathomics to establish a biosignature for aggressive skin melanoma
PROJECT SUMMARY We propose to develop a pathomics biosignature for aggressive melanoma to guide treatment decisions for patients who have had a melanoma surgically removed but rema...
Prediagnostic exposures, germline genetics, and triple negative breast cancer mutational and immune profiles
Triple negative breast cancer (TNBC) are typically aggressive cancers with shorter median time to relapse and death than other breast cancers. Because these cancers are defined by...
Small-Molecule Covalent E6 Antagonists for Treatment of HPV Infection
ABSTRACT “High-risk” human papillomavirus (HPV) types such as 16 (HPV-16) are identified in the majority of HPV- associated pre-malignant and malignant pathologies of cervical, ano...
Targeting the Stroma for Pancreatic Cancer Treatment
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies despite the recent paradigm shifting success of immunotherapy noted in many other...
Proteolysis-targeting chimera against BCL-XL inhibits breast cancer metastasis
Project Summary-Abstract Metastasis is the major cause of BrCa death. Most women with metastatic BrCa (stage IV) are treated mainly with systemic therapy such as hormone therapy (f...
Integrated visualization, control, and analysis of GEF – GTPase networks in living cells
A small number of Rho family GTPases participate in a broad array of fundamental cellular behaviors. Specificity is possible due to spatial and temporal control of GTPase “activati...
Role of RABL6A-PP2A in neuroendocrine tumors
Project Summary / Abstract Neuroendocrine tumors (NETs) are incurable, clinically challenging malignancies that are rising in incidence. Although tumors grow slowly, they progress...
Regulatory Crosstalk Between Human Endogenous Retroviruses, HIV, and EBV, in Lymphoma
PROJECT SUMMARY/ABSTRACT Approximately 8% of the human genome is composed of sequences directly derived from germline infections of diverse retroviruses, which have accumulated ove...
SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer
Head and neck cancers (HNCs) account for nearly 3% of all cancers in the U.S. and most commonly affect aging individuals. While chemo-radiotherapy is the standard treatment approac...
SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer
Head and neck cancers (HNCs) account for nearly 3% of all cancers in the U.S. and most commonly affect aging individuals. While chemo-radiotherapy is the standard treatment approac...
Identifying therapeutic pathways targeting medulloblastoma-immune cell interactions
SUMMARY We propose developing a systems-biology approach to understand interactions between tumor and immune cells and their clinical implications. Our work will focus on medullobl...
Development of a 3D Imaging Diagnostic Tool for the Improved Characterization of Metastatic Melanoma
Summary The objective of this Phase II project is to improve outcomes and survival for patients with melanoma by reducing the number of false negative sentinel lymph node biopsies...
Multi-scale modeling of glioma for the prediction of treatment response, treatment monitoring and treatment allocation
Project Summary/Abstract Novel molecular technologies such as single cell RNA seq and DNA methylation assays have now become routine techniques for gathering data at the molecular...
Investigation of the mitochondrial function in GNAS mutant neoplasms
Emerging evidences pointing out the requirement of mitochondrial function in the oncogenesis processes, but how the mitochondrial state is changed in different set of oncogenic mut...
Validating Urine Derived Cancer Cells (UDCC) -- Non-Invasive and Living Liquid Biopsies -- in Bladder Cancer Clinics
PROJECT SUMMARY Bladder cancer (BC) is the costliest cancer (per case) among all cancer types and yet among the top 10 cancers it is the most underfunded cancer by NCI. There has b...
Targeting the Stroma for Pancreatic Cancer Treatment
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies despite the recent paradigm shifting success of immunotherapy noted in many other...
Role of ALDH in PARP inhibitor resistance in HR-deficient ovarian cancer
Summary Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are an exciting and promising new class of anticancer drugs, which have been approved by the FDA for recurrent ovaria...
Copper-mediated metabolic reprogramming and ECM alterations in TNBC metastasis
Triple negative breast cancer (TNBC) patients present a formidable clinical challenge, as they exhibit higher rates of metastatic recurrence, and respond poorly to available target...