Browse All Grants
20,252 grants found
Showing 17,881 – 17,900 of 20,252 grants
Paper-based Breastmilk Collection System for Facile, In-Home Use
Project Summary / Abstract This project will conduct early-stage development of a paper-based device to facilitate the efficient recovery of high-quality nucleic acids from breastm...
Regulatory Crosstalk Between Human Endogenous Retroviruses, HIV, and EBV, in Lymphoma
PROJECT SUMMARY/ABSTRACT Approximately 8% of the human genome is composed of sequences directly derived from germline infections of diverse retroviruses, which have accumulated ove...
Stat4Onc Annual Symposium
Project Summary/Abstract Cancer is the 2nd leading cause of death in US. Statistical designs and data analytics approaches are instrumental in recent development of more effective...
Linking Genetic, Epigenetic and Signaling Mechanisms of Oncogene Addiction
PROJECT SUMMARY Our long-term goal is to build a network-level and single-cell understanding of the interplay between genetic, epigenetic and signaling mechanisms that determine th...
Cancer-prone cell states of the fallopian tubal epithelium
Project Summary Ovarian/extra-uterine high-grade serous carcinoma (HGSC) is the most common and aggressive type of ovarian cancer. It often has no symptoms at early stages and over...
A Registry-Based Study of Patterns of Use of Targeted Therapies for Metastatic Cancers in Diverse Populations
One of the most important cancer care advances in recent history is the rapid dissemination of targeted therapies (molecularly targeted kinase inhibitors and immune checkpoint inhi...
Mechanisms of Variant ER-alpha Function in Breast Cancer
PROJECT SUMMARY / ABSTRACT Estrogen receptor-alpha (ER), a member of the nuclear receptor family of transcription factors, drives proliferation of breast cancer cells and is expres...
Microbiota, Metabolites, and Colon Neoplasia
Project Summary The human diet can positively or negatively impact cancer incidence, with plant-derived compounds – such as polyphenols – often exhibiting antioxidant cancer-preven...
Clinical Utility of Biomarkers Driven Management of Indeterminate Pulmonary Nodules
PROJECT SUMMARY The goal of this application is to test the clinical utility of a biomarker-informed approach to the evaluation and management of indeterminate pulmonary nodules (I...
Identifying therapeutic pathways targeting medulloblastoma-immune cell interactions
SUMMARY We propose developing a systems-biology approach to understand interactions between tumor and immune cells and their clinical implications. Our work will focus on medullobl...
Immunity to commensal papillomaviruses for cancer therapy
Project Summary/Abstract: Research in the field of microbiome has largely focused on the beneficial effects of commensal bacteria in regulating tissue homeostasis and the immune re...
Multi-scale modeling of glioma for the prediction of treatment response, treatment monitoring and treatment allocation
Project summary Computational multi-scale modeling is a growing area of research that aims to link whole slide images and radiographic iamges with multi-omics molecular profiles of...
Applying deep learning to predict T cell receptor binding specificity of neoantigens and response to checkpoint inhibitors
Project Summary Background: In-depth study of neoantigens will promote our knowledge of the fundamental mechanisms of basic immunology and immune-related disease processes, such as...
Development of Rationally Designed Cancer Vaccines Using Protein-like Polymers (PLPs)
PROJECT SUMMARY The utilization of tumor antigens, which are antigenic peptides expressed in cancer cells as a result of random somatic mutations, for the development of patient-sp...
Copper-mediated metabolic reprogramming and ECM alterations in TNBC metastasis
Triple negative breast cancer (TNBC) patients present a formidable clinical challenge, as they exhibit higher rates of metastatic recurrence, and respond poorly to available target...
Biological determinants of colorectal cancer outcomes in Latinos of diverseýancestral origins
ABSTRACT Hispanics/Latinos (Latinos) are the 2nd largest and fastest growing ethnic group in the United States. Although typically grouped as a single ethnic minority, Latinos are...
Mechanisms of the BRCA-network in tumorigenesis and therapeutic response
Mechanisms of the BRCA-network in Tumorigenesis and Therapeutic Response (OVERALL) Abstract: The faithful repair of DNA damage and efficient resolution of stalled replication forks...
Project 1: Recruitment of the BRCA1-associated Homologous Recombination Machinery
PROJECT SUMMARY: “RECRUITMENT OF THE BRCA1-ASSOCIATED HOMOLOGOUS RECOMBINATION MACHINERY” A substantial proportion of tumors show patterns of mutation that arise because of problem...
Project 2: Targeting DNA replication in BRCA-associated breast cancer
PROJECT SUMMARY Germline mutations in BRCA1 and BRCA2 and PALB2 predispose to breast cancer and also increase the risks of ovarian, pancreatic, prostate, and other cancers. The pro...
Project 3: Chromatin modifiers of BRCA-related DNA repair Pathways
PROJECT SUMMARY/ABSTRACT: Induction of a DNA break initiates DNA damage signaling pathways that lead to coordinated and dynamic modification of the local chromatin landscape, inclu...