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20,252 grants found
Showing 17,861 – 17,880 of 20,252 grants
The Nathan Schnaper Intern Program in Translational Cancer Research
Significant progress in detection and treatment has reduced cancer mortality rates; however, with over 1.7 million new cases and 600,000 deaths from cancer reported in 2019, it rem...
Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance
PROJECT SUMMARY Prostate cancer (PCa) is the most commonly diagnosed cancer among American men and metastatic Castration- Resistant Prostate Cancer (mCRPC) is the mostly deadly for...
Support of the North American Association of Central Cancer Registries, Inc. (NAACCR) Annual Scientific Conference
NAACCR Annual Scientific Conference Project Summary R13 20-207 Cancer surveillance data are the lynchpin of the cancer data ecosystem. Only through the collection of accurate, stan...
Administrative Core
ABSTRACT: The Administrative Core (Admin Core) of the program project “Mechanisms of the BRCA-network in Tumorigenesis and Therapeutic Response” will effectively manage all aspects...
Core 1: Mouse and Cell Modeling
PROJECT SUMMARY (Core-1) Genetically engineered cell lines and mouse models are critical for elucidating complex biological processes. The ability to customize the context in which...
Core 2: Genomics
ABSTRACT The Genomics Core (Core 2) will provide support with genomics profiling and integrative bioinformatics analysis support for all the four projects, contributing towards the...
Chromosome 1q ceRNAs in Melanoma Progression and Metastasis
PROJECT SUMMARY Metastasis is the main cause of deaths related to malignant melanoma. Studies over the last decade have revealed that the metastatic process is not primarily driven...
Defining metabolic adaptations within the PDAC "arid" tumor microenvironment
PROJECT SUMMARY The goal of our proposal is to identify therapeutic vulnerabilities associated with nutrient-poor conditions in tumors. Pancreatic ductal adenocarcinoma (PDAC) rema...
Radiomics and Pathomics to predict upstaging of DCIS
Abstract Ductal carcinomas in situ (DCIS) of the breast are a heterogeneous group of neoplastic lesions that are usually detected by screening mammography. Workup generally include...
Mechanistic investigations of microbiome-driven aryl hydrocarbon receptor activity and macrophage function in pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer- related death. This is attributable to the asymptomatic early stages of disease, the fibrotic nature...
Investigating contributions of BRCA2 DNA-binding domains toward maintaining genome integrity
ABSTRACT Conserved mechanisms exist to eliminate DNA damage, which, if left unrepaired, can cause gene mutations and genome rearrangements to trigger neoplastic cell transformation...
Multiethnic GWAS and TWAS to Inform Risk Prediction for Prostate Cancer
Abstract Prostate cancer (PCa) incidence is highest in African Americans and lowest in Asians. These long-standing racial/ethnic differences have yet to be explained. Genome-wide a...
Exosomes in HNSCC Progression
Exosomes are small extracellular vesicles (EVs) that are secreted from multivesicular endosomes (MVE) and have been recently recognized to promote cancer metastasis. Exosomes carry...
Development and Commercialization of a New Molecularly Targeted Imaging Agent for Multiple Myeloma
PROJECT SUMMARY Sarya LLC (Sarya) is a nuclear medicine technology company formed to commercialize radiopharmaceuticals. The goal of this Fast-Track STTR is to develop a new specif...
Chromosome 1q ceRNAs in Melanoma Progression and Metastasis
PROJECT SUMMARY – Per Parent Award R01CA259046 Metastasis is the main cause of deaths related to malignant melanoma. Studies over the last decade have revealed that the metastatic...
Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance
PROJECT SUMMARY Prostate cancer (PCa) is the most commonly diagnosed cancer among American men and metastatic Castration- Resistant Prostate Cancer (mCRPC) is the mostly deadly for...
Administrative Supplement to Dual function of HSP70 in cytoprotection of tumor cells and generation of permissive microenvironment
It has been widely accepted that distinct epithelial to mesenchymal transition (EMT) phenotype and cancer stem cell (CSC) properties as well as the immunosuppressive tumor microenv...
Avanzando Caminos (Leading Pathways): The Hispanic/Latino Cancer Survivorship Cohort Study.”
Project Summary Cancer is the leading cause of death among Hispanics/Latinos (H/Ls) in the US. H/Ls account for 57.5 million Americans (18%), now the largest minority expected to d...
Dietary Regulation of Colon Cancer Metastasis
Project Summary/AbstractColorectal cancer (CRC) is the third most frequent cancer worldwide with increasing incidences every year. It is the leading cause of cancer related mortali...
Defining metabolic adaptations within the PDAC "arid" tumor microenvironment
PROJECT SUMMARY The goal of our proposal is to identify therapeutic vulnerabilities associated with nutrient-poor conditions in tumors. Pancreatic ductal adenocarcinoma (PDAC) rema...