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20,252 grants found
Showing 17,841 – 17,860 of 20,252 grants
SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer
Head and neck cancers (HNCs) account for nearly 3% of all cancers in the U.S. and most commonly affect aging individuals. While chemo-radiotherapy is the standard treatment approac...
SUMO Modification and Cancer Therapy
Many enzymes catalyzing ubiquitin-like (Ubl) modifications have been identified as targets for the therapeutic development of life-threatening human diseases that lack a cure. Howe...
A Registry-Based Study of Patterns of Use of Targeted Therapies for Metastatic Cancers in Diverse Populations
One of the most important cancer care advances in recent history is the rapid dissemination of targeted therapies (molecularly targeted kinase inhibitors and immune checkpoint inhi...
Microfluidic tumor tissue processing platform for single cell diagnostics
ABSTRACT Solid tumors are diverse ecosystems of different cell types, and this heterogeneity has been implicated as a key factor driving disease progression, metastasis, and drug r...
Clinical Utility of Biomarkers Driven Management of Indeterminate Pulmonary Nodules
PROJECT SUMMARY The goal of this application is to test the clinical utility of a biomarker-informed approach to the evaluation and management of indeterminate pulmonary nodules (I...
SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer
Head and neck cancers (HNCs) account for nearly 3% of all cancers in the U.S. and most commonly affect aging individuals. While chemo-radiotherapy is the standard treatment approac...
SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer
Head and neck cancers (HNCs) account for nearly 3% of all cancers in the U.S. and most commonly affect aging individuals. While chemo-radiotherapy is the standard treatment approac...
Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance
PROJECT SUMMARY Prostate cancer (PCa) is the most commonly diagnosed cancer among American men and metastatic Castration- Resistant Prostate Cancer (mCRPC) is the mostly deadly for...
Development and Commercialization of a New Molecularly Targeted Imaging Agent for Multiple Myeloma
PROJECT SUMMARY Sarya LLC (Sarya) is a nuclear medicine technology company formed to commercialize radiopharmaceuticals. The goal of this Fast-Track STTR is to develop a new specif...
Dual function of HSP70 in cytoprotection of tumor cells and generation of permissive microenvironment
It has been widely accepted that distinct epithelial to mesenchymal transition (EMT) phenotype and cancer stem cell (CSC) properties as well as the immunosuppressive tumor microenv...
Deciphering Mechanisms of Tumor-Stromal Interactions in Prostate Cancer
Project Summary/Abstract Prostate cancer (PC) affects 1 in 9 men and causes nearly 30,000 yearly deaths in the United States. Understanding the PC tumor microenvironment (TME) is e...
An Addictions Neuroclinical Assessment Based Treatment for Smokers with an Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT Together, tobacco and alcohol kill more than half a million people in the United States every year, making co- addiction to these substances the leading ca...
Improving treatment of HER2+ breast cancer brain metastasis by targeting lipid metabolism
ABSTRACT Patients with HER2 positive (HER2+) breast cancer (~14% of breast cancer patients) have a high risk of developing brain metastases (34%). The development of novel HER2 tar...
Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer
Project Summary/Abstract The ultimate goal of this mPI proposal is to address a fundamental gap in knowledge on the role of acetyl-CoA metabolic reprogramming in regulating cyclin...
Paper-based Breastmilk Collection System for Facile, In-Home Use
Project Summary / Abstract This project will conduct early-stage development of a paper-based device to facilitate the efficient recovery of high-quality nucleic acids from breastm...
Dual function of HSP70 in cytoprotection of tumor cells and generation of permissive microenvironment
It has been widely accepted that distinct epithelial to mesenchymal transition (EMT) phenotype and cancer stem cell (CSC) properties as well as the immunosuppressive tumor microenv...
Decoupling Bidirectional EphB/ephrinB2 in Multiple Myeloma
Project Summary/Abstract My research objectives are to study the impact of decoupling the EphB4/ephrinB2 axis in multiple myeloma (MM), a cancer of antibody-secreting plasma cells,...
Reduction of Tumor-Positive Margins in Oncology Surgery
Project Abstract Approximately 80% of early stage head and neck tumors undergo surgery of curative intent at some point in their treatment course. The success of this oncologic sur...
Drug eluting injectable biomaterials for next generation chemoembolization
Abstract Hepatocellular carcinoma (HCC), the most common type of liver cancer, is a major worldwide public health concern because it is often detected at advanced stages where trea...
SUMO Modification and Cancer Therapy
Many enzymes catalyzing ubiquitin-like (Ubl) modifications have been identified as targets for the therapeutic development of life-threatening human diseases that lack a cure. Howe...