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20,252 grants found
Showing 17,821 – 17,840 of 20,252 grants
Determining mechanisms of PRC2-mediated disease using Drosophila
PROJECT ABSTRACT/SUMMARY Normal development requires tightly controlled gene expression to precisely regulate tissue patterning and failure to properly control the expression profi...
Reduction of Tumor-Positive Margins in Oncology Surgery
Project Abstract Approximately 80% of early stage head and neck tumors undergo surgery of curative intent at some point in their treatment course. The success of this oncologic sur...
SUMO Modification and Cancer Therapy
Many enzymes catalyzing ubiquitin-like (Ubl) modifications have been identified as targets for the therapeutic development of life-threatening human diseases that lack a cure. Howe...
Melanoma NAMPT mediates resistance to the anti-proliferative effects of Interferons (IFNs) and IFN based immunotherapies such as STING Agonists
Project Abstract Immune cells infiltrate the tumor microenvironment (TME) and secrete inflammatory cytokines such as interferons (IFNs) in order to drive anti-tumor responses and t...
Small-Molecule Covalent E6 Antagonists for Treatment of HPV Infection
ABSTRACT “High-risk” human papillomavirus (HPV) types such as 16 (HPV-16) are identified in the majority of HPV- associated pre-malignant and malignant pathologies of cervical, ano...
Decoupling Bidirectional EphB/ephrinB2 in Multiple Myeloma
Project Summary/Abstract My research objectives are to study the impact of decoupling the EphB4/ephrinB2 axis in multiple myeloma (MM), a cancer of antibody-secreting plasma cells,...
Mechanistic investigations of microbiome-driven aryl hydrocarbon receptor activity and macrophage function in pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer- related death. This is attributable to the asymptomatic early stages of disease, the fibrotic nature...
Integrated visualization, control, and analysis of GEF – GTPase networks in living cells
A small number of Rho family GTPases participate in a broad array of fundamental cellular behaviors. Specificity is possible due to spatial and temporal control of GTPase “activati...
Biological determinants of colorectal cancer outcomes in Latinos of diverseýancestral origins
ABSTRACT Hispanics/Latinos (Latinos) are the 2nd largest and fastest growing ethnic group in the United States. Although typically grouped as a single ethnic minority, Latinos are...
CXCL5/CXCR2 axis as a therapeutic vulnerability of breast cancer metastasis to bone
PROJECT SUMMARY/ABSTRACT The majority of breast cancers express estrogen receptor a (ER+), a molecule that typically promotes cell proliferation when activated by its ligand estrog...
Multiethnic GWAS and TWAS to Inform Risk Prediction for Prostate Cancer
Abstract Prostate cancer (PCa) incidence is highest in African Americans and lowest in Asians. These long-standing racial/ethnic differences have yet to be explained. Genome-wide a...
Exosomes in HNSCC Progression
Exosomes are small extracellular vesicles (EVs) that are secreted from multivesicular endosomes (MVE) and have been recently recognized to promote cancer metastasis. Exosomes carry...
The Nathan Schnaper Intern Program in Translational Cancer Research
Significant progress in detection and treatment has reduced cancer mortality rates; however, with over 1.7 million new cases and 600,000 deaths from cancer reported in 2019, it rem...
Improving treatment of HER2+ breast cancer brain metastasis by targeting lipid metabolism
ABSTRACT Patients with HER2 positive (HER2+) breast cancer (~14% of breast cancer patients) have a high risk of developing brain metastases (34%). The development of novel HER2 tar...
Deciphering Mechanisms of Tumor-Stromal Interactions in Prostate Cancer
Project Summary/Abstract Prostate cancer (PC) affects 1 in 9 men and causes nearly 30,000 yearly deaths in the United States. Understanding the PC tumor microenvironment (TME) is e...
Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance
PROJECT SUMMARY Prostate cancer (PCa) is the most commonly diagnosed cancer among American men and metastatic Castration- Resistant Prostate Cancer (mCRPC) is the mostly deadly for...
Radiomics and Pathomics to predict upstaging of DCIS
Abstract Ductal carcinomas in situ (DCIS) of the breast are a heterogeneous group of neoplastic lesions that are usually detected by screening mammography. Workup generally include...
Mechanisms of Variant ER-alpha Function in Breast Cancer
PROJECT SUMMARY / ABSTRACT Estrogen receptor-alpha (ER), a member of the nuclear receptor family of transcription factors, drives proliferation of breast cancer cells and is expres...
An Addictions Neuroclinical Assessment Based Treatment for Smokers with an Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT Together, tobacco and alcohol kill more than half a million people in the United States every year, making co- addiction to these substances the leading ca...
Defining the role of Taiman, the Drosophila homolog of AIB1, as a super-competitor in developing epithelia
PROJECT SUMMARY Invasive breast cancer is a deadly disease, killing ~42,000 women each year and costing the United States over $16.5 billion annually. The complicated disease mecha...