Browse All Grants
20,252 grants found
Showing 17,801 – 17,820 of 20,252 grants
Project 4: The BRCA Network in Medulloblastoma Responses to Replication Stress
The BRCA Network in Medulloblastoma Responses to Replication Stress (Project-4) Abstract: BRCA1 and BRCA2 are critical genes for the repair of DNA strand breaks (DSB) via homologou...
Administrative Core
ABSTRACT: The Administrative Core (Admin Core) of the program project ?Mechanisms of the BRCA-network in Tumorigenesis and Therapeutic Response? will effectively manage all aspects...
Core 1: Mouse and Cell Modeling
PROJECT SUMMARY (Core-1) Genetically engineered cell lines and mouse models are critical for elucidating complex biological processes.The ability to customize the context in which...
Core 2: Genomics
ABSTRACT The Genomics Core (Core 2) will provide support with genomics profiling and integrative bioinformatics analysis support for all the four projects, contributing towards the...
Exosomes in HNSCC Progression
Exosomes are small extracellular vesicles (EVs) that are secreted from multivesicular endosomes (MVE) and have been recently recognized to promote cancer metastasis.Exosomes carry...
Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer
Project Summary/Abstract The ultimate goal of this mPI proposal is to address a fundamental gap in knowledge on the role of acetyl-CoA metabolic reprogramming in regulating cyclin...
Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance
PROJECT SUMMARY Prostate cancer (PCa) is the most commonly diagnosed cancer among American men and metastatic Castration- Resistant Prostate Cancer (mCRPC) is the mostly deadly for...
Investigation of the mitochondrial function in GNAS mutant neoplasms
Emerging evidences pointing out the requirement of mitochondrial function in the oncogenesis processes, but how the mitochondrial state is changed in different set of oncogenic mut...
Universal Sample Multiplexing for Single Cell Analysis
ABSTRACT Cancer progression and resistance to therapy are strongly influenced by tumor heterogeneity.Single-cell RNA sequencing (scRNAseq) is a valuable tool for cancer research be...
Clinical Utility of Biomarkers Driven Management of Indeterminate Pulmonary Nodules
PROJECT SUMMARY The goal of this application is to test the clinical utility of a biomarker-informed approach to the evaluation and management of indeterminate pulmonary nodules (I...
Enhancing cognitive function in breast cancer survivors through community-based aerobic exercise training
Project Summary Women aged 50+ years comprise 77% of breast cancer diagnoses and 93% of all breast cancer survivors (BCS). Unfortunately, the interaction between cancer treatment a...
Microbiota, Metabolites, and Colon Neoplasia
Project Summary The human diet can positively or negatively impact cancer incidence, with plant-derived compounds ? such as polyphenols ? often exhibiting antioxidant cancer-preven...
Avanzando Caminos (Leading Pathways): The Hispanic/Latino Cancer Survivorship Cohort Study.”
Project Summary Cancer is the leading cause of death among Hispanics/Latinos (H/Ls) in the US. H/Ls account for 57.5 million Americans (18%), now the largest minority expected to d...
Small-Molecule Covalent E6 Antagonists for Treatment of HPV Infection
ABSTRACT ?High-risk? human papillomavirus (HPV) types such as 16 (HPV-16) are identified in the majority of HPV- associated pre-malignant and malignant pathologies of cervical, ano...
Integrated visualization, control, and analysis of GEF – GTPase networks in living cells
A small number of Rho family GTPases participate in a broad array of fundamental cellular behaviors.Specificity is possible due to spatial and temporal control of GTPase ?activatio...
Enhancing cognitive function in breast cancer survivors through community-based aerobic exercise training
Project Summary Women aged 50+ years comprise 77% of breast cancer diagnoses and 93% of all breast cancer survivors (BCS). Unfortunately, the interaction between cancer treatment a...
Melanoma NAMPT mediates resistance to the anti-proliferative effects of Interferons (IFNs) and IFN based immunotherapies such as STING Agonists
Project Abstract Immune cells infiltrate the tumor microenvironment (TME) and secrete inflammatory cytokines such as interferons (IFNs) in order to drive anti-tumor responses and t...
Small-Molecule Covalent E6 Antagonists for Treatment of HPV Infection
ABSTRACT “High-risk” human papillomavirus (HPV) types such as 16 (HPV-16) are identified in the majority of HPV- associated pre-malignant and malignant pathologies of cervical, ano...
Prediagnostic exposures, germline genetics, and triple negative breast cancer mutational and immune profiles
Triple negative breast cancer (TNBC) are typically aggressive cancers with shorter median time to relapse and death than other breast cancers. Because these cancers are defined by...
Defining metabolic adaptations within the PDAC "arid" tumor microenvironment
PROJECT SUMMARY The goal of our proposal is to identify therapeutic vulnerabilities associated with nutrient-poor conditions in tumors. Pancreatic ductal adenocarcinoma (PDAC) rema...