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20,252 grants found
Showing 17,781 – 17,800 of 20,252 grants
Targeting the Stroma for Pancreatic Cancer Treatment
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies despite the recent paradigm shifting success of immunotherapy noted in many other...
Dietary Regulation of Colon Cancer Metastasis
Project Summary/AbstractColorectal cancer (CRC) is the third most frequent cancer worldwide with increasing incidences every year. It is the leading cause of cancer related mortali...
Targeting Checkpoint Inhibition in Anti-Tumor Responses
PROJECT SUMMARY The goal of this project is to evaluate novel therapeutics that block PSGL-1 (P-selectin glycoprotein-1), which we identified as a key inhibitory receptor (IR) that...
Targeting purine biosynthesis to radiosensitize glioblastoma
Project Summary/Abstract Glioblastoma (GBM) is the most common aggressive primary brain tumor and is uniformly fatal with a median survival of around 1.5-years. Like surgery and ch...
Radiomics and Pathomics to predict upstaging of DCIS
Abstract Ductal carcinomas in situ (DCIS) of the breast are a heterogeneous group of neoplastic lesions that are usually detected by screening mammography. Workup generally include...
Origins and functions of pancreatic cancer-associated fibroblasts
PROJECT SUMMARY/ABSTRACT The mechanisms underlying evolution of tumor-associated stroma remain poorly understood. In solid tumors featuring a prominent stromal reaction, an improve...
Integrated visualization, control, and analysis of GEF – GTPase networks in living cells
A small number of Rho family GTPases participate in a broad array of fundamental cellular behaviors. Specificity is possible due to spatial and temporal control of GTPase “activati...
Repurposing Leflunomide to Delay Progression of Smoldering Multiple Myeloma in African Americans
PROJECT SUMMARY Smoldering multiple myeloma (SMM) is an asymptomatic precursor of active multiple myeloma (MM), and 50 percent of patients meeting criteria for high-risk disease wi...
Applying deep learning to predict T cell receptor binding specificity of neoantigens and response to checkpoint inhibitors
Project Summary Background: In-depth study of neoantigens will promote our knowledge of the fundamental mechanisms of basic immunology and immune-related disease processes, such as...
Understanding the Role of Macrophages and Iron in the Tumor Microenvironment
PROJECT SUMMARY/ABSTRACT Glioblastoma is one of the most aggressive and hard to treat human cancers facing modern medicine. The current standard of care for a new diagnosis of glio...
Role of RABL6A-PP2A in neuroendocrine tumors
Project Summary / Abstract Neuroendocrine tumors (NETs) are incurable, clinically challenging malignancies that are rising in incidence. Although tumors grow slowly, they progress...
Mechanisms of the BRCA-network in tumorigenesis and therapeutic response
Mechanisms of the BRCA-network in Tumorigenesis and Therapeutic Response (OVERALL) Abstract: The faithful repair of DNA damage and efficient resolution of stalled replication forks...
Project 1: Recruitment of the BRCA1-associated Homologous Recombination Machinery
PROJECT SUMMARY: “RECRUITMENT OF THE BRCA1-ASSOCIATED HOMOLOGOUS RECOMBINATION MACHINERY” A substantial proportion of tumors show patterns of mutation that arise because of problem...
Project 2: Targeting DNA replication in BRCA-associated breast cancer
PROJECT SUMMARY Germline mutations in BRCA1 and BRCA2 and PALB2 predispose to breast cancer and also increase the risks of ovarian, pancreatic, prostate, and other cancers. The pro...
Core 1: Mouse and Cell Modeling
PROJECT SUMMARY (Core-1) Genetically engineered cell lines and mouse models are critical for elucidating complex biological processes. The ability to customize the context in which...
Core 2: Genomics
ABSTRACT The Genomics Core (Core 2) will provide support with genomics profiling and integrative bioinformatics analysis support for all the four projects, contributing towards the...
Role of ALDH in PARP inhibitor resistance in HR-deficient ovarian cancer
Summary Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are an exciting and promising new class of anticancer drugs, which have been approved by the FDA for recurrent ovaria...
Multiethnic GWAS and TWAS to Inform Risk Prediction for Prostate Cancer
Abstract Prostate cancer (PCa) incidence is highest in African Americans and lowest in Asians. These long-standing racial/ethnic differences have yet to be explained. Genome-wide a...
Project 2: Targeting DNA replication in BRCA-associated breast cancer
PROJECT SUMMARY Germline mutations in BRCA1 and BRCA2 and PALB2 predispose to breast cancer and also increase the risks of ovarian, pancreatic, prostate, and other cancers.The prod...
Project 3: Chromatin modifiers of BRCA-related DNA repair Pathways
PROJECT SUMMARY/ABSTRACT: Induction of a DNA break initiates DNA damage signaling pathways that lead to coordinated and dynamic modification of the local chromatin landscape, inclu...