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20,252 grants found
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PPARD hyperactivation promotes pancreatic intraepithelial neoplasia progression into pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDA) incidence is rising. Pancreatic intraepithelial neoplasms (PanINs) are PDA precursors that are common in asymptomatic adults, but only few pr...
Tumor-activatable Interleukin-2 Superkine Nanoparticle Therapy
Abstract Interleukin-2 (IL-2) is an immunostimulatory cytokine that plays a central role in antitumor immunity, particularly in the activation and proliferation of T cells and natu...
Exploring new strategy for breast cancer immunoprevention by targeting histamine receptor H1
Project Summary/Abstract New strategies to prevent breast cancer are urgently needed because: i) breast cancer incidence rates keep rising by 0.5% per year and about 13%, or 1 in 8...
Improving Strategies for Cancer Reduction through Early-detection and ENgagement (I-SCREEN)
ABSTRACT Leveraging decades of NCI investments in clinical trials, data infrastructure, and cancer screening research, the I-SCREEN (Improving Strategies for Cancer Reduction throu...
Virginia Cancer Screening Research Network Access Hub (Virginia CSRN Hub)
PROJECT SUMMARY New cancer screening technologies with great promise for reducing cancer death are emerging. These technologies require large-scale, controlled clinical trials to e...
Oklahoma Tribal, Rural, Urban Cancer Screening Trial ACCESS Hub
Project Summary/Abstract. The overarching goal for the Stephenson Cancer Center (SCC) Oklahoma Tribal, Rural, Urban Cancer Screening Trial (OK TRUST) ACCESS Hub is to enhance capac...
Computational and functional discovery of isoforms driving cancer and drug resistance
ABSTRACT A major challenge for the cancer genomics community is determining which somatic mutations are contributing to tumorigenesis, which are “passenger” (neutral) mutations, an...
Project 2
Project Summary Survival for breast, prostate and colorectal cancer has improved dramatically over the past three decades as a result of advances in treatment and screening for the...
Genetic Variation in Cancer Risk and Outcomes in African Americans
African Americans experience higher cancer incidence and mortality rates, are diagnosed at more advanced stages, and have poorer overall survival than other populations. They are a...
Admin Core
Project Summary The Program entitled “Genetic Variation in Cancer Risk and Outcomes in African Americans” comprises three Research Projects and two Shared Resource Core components...
Core 1
PROJECT SUMMARY—Data Collection and Clinical Genetics Core The Program entitled “Genetic Variation in Cancer Risk and Outcomes in African Americans” comprises three Research Projec...
Validation of Quality Measures for Patient-Centered Cancer Communication in Rwanda
PROJECT SUMMARY/ABSTRACT The burden of cancer is rising in Africa and mortality rates are high. A majority (70-80%) of patients present at advanced stages, and cancer care incurs s...
Genetic Variation in Cancer Risk and Outcomes in African Americans
Project Summary/Abstract—Overall Program Genetic testing for both germline and somatic mutations has improved our understanding of the basic biology of carcinogenesis, identified h...
Project 1
Project Summary Understanding the spectrum of germline mutations underlying hereditary cancers has clear clinical implications, and while mutations in at least four dozen genes hav...
Statistics and Data Management Center (SDMC) for the NCI Cancer Screening Research Network (CSRN)
Multi-cancer detection assays offer new opportunities to screen for many different cancers that currently have limited options for early detection. The Cancer Screening Research Ne...
A Real-Time AI-Driven High-Throughput Proteomics Data Acquisition Method for Clinical Applications
SUMMARY Cancer is caused by dynamics of the genome, which ultimately translate into aberrations of the proteome constituting the major functional and structural components of a cel...
Development of Heterobivalent Small-Molecule Therapeutics for the Treatment of Triple-Negative Breast Cancer
ABSTRACT Breast cancer is the most prevalent cancer in women and the second leading cause of cancer related death. Approximately 20% of breast cancer cases are triple negative brea...
Explainable Artificial Intelligence for Melanoma Recurrence Prediction via Integrative Modeling of Multiplexed Imaging with Transcriptomics and Histopathology
ABSTRACT Recurrence from early-stage (stage I/II) primary melanomas, often undetected until symptomatic metastasis, accounts for most melanoma mortality. Current prognostic tools a...
NCI Cancer Screening Research Network: Coordinating and Communication Center
SUMMARY/ABSTRACT The promise of early detection to reduce the burden of cancer is an easily understood and highly desired intervention point in the cancer continuum. Recent develop...
Hybrid Trial of a Tailored Smoking Cessation Digital Therapeutic for Persons Living with HIV
PROJECT ABSTRACT Tobacco use has alarmingly high rates among people with HIV (PWH), 43% compared with 15% in the general population. Due to the development of highly effective trea...