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20,252 grants found
Showing 17,741 – 17,760 of 20,252 grants
Drug eluting injectable biomaterials for next generation chemoembolization
Abstract Hepatocellular carcinoma (HCC), the most common type of liver cancer, is a major worldwide public health concern because it is often detected at advanced stages where trea...
Determining mechanisms of PRC2-mediated disease using Drosophila
PROJECT ABSTRACT/SUMMARY Normal development requires tightly controlled gene expression to precisely regulate tissue patterning and failure to properly control the expression profi...
Site-Specific Antibody for Protein Poly-ADP-Ribosylation
Poly-ADP-ribosylation (PARylation) is a protein posttranslational modification (PTM) that is catalyzed by a family of enzymes known as Poly-ADP-ribose polymerases (PARPs). Among th...
SUMO Modification and Cancer Therapy
Many enzymes catalyzing ubiquitin-like (Ubl) modifications have been identified as targets for the therapeutic development of life-threatening human diseases that lack a cure.Howev...
Development of a 3D Imaging Diagnostic Tool for the Improved Characterization of Metastatic Melanoma
Summary The objective of this Phase II project is to improve outcomes and survival for patients with melanoma by reducing the number of false negative sentinel lymph node biopsies...
Design and Testing of a mHealth App for Ambivalent Smokers Living with HIV: A Randomized Pilot Study
PROJECT SUMMARY Reducing smoking among PLWH is a recognized public health priority.Smoking rates are up to 2-3 times higher among PLWH than in the general population and with the w...
A low-cost topical immunotherapy formulation suitable for treating cervical cancer in low and middle income countries and low-resource settings in the U.S.
The goal of this project is to deliver an affordable immunotherapy to treat advanced cervical cancer in low- and middle-income countries (LMICs) and low-resource settings in the U....
Preloading with Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts
ABSTRACT Cigarette smoking is more prevalent in persons with HIV (PWH) in the U.S. when compared with the general population and is linked to increased morbidity and mortality in t...
A novel T cell subset with increased potency and persistence for the treatment of solid tumors
Project Summary Cancer is the second leading cause of death in the US and despite efforts to develop small molecule and biological therapies, several solid tumors still have 5-year...
PATIENT-SPECIFIC NARROW BEAM BREAST CT
Project Summary/Abstract Early and reliable detection of breast cancer remains a challenge, particularly in women with dense and extremely dense breasts.Breast density is associate...
Furthering the clinical development of a first in class, water resistant sunscreen to meet emerging environmental regulations
PROJECT SUMMARY / ABSTRACT Problem to be Solved and Significance: Exposure to Ultraviolet radiation (UVR) is a risk factor for the development of skin cancer, and health care agenc...
Engineered TCR-T Cell Therapy Targeting Driver Mutations in NSCLC
PROJECT SUMMARY Project Title: Engineered TCR-T Cell Therapy Targeting Driver Mutations in NSCLC Organization: GigaMune Inc. PI: Matthew J Spindler, Ph.D.Adoptive cell therapies (A...
Inhibition of CaVα-β interaction with orally available small organic molecules for chronic pain
ABSTRACT Revisions noted in blue font Chemotherapy-induced peripheral neuropathy (CIPN) is a common (prevalence 30?70%) and potentially dose- limiting side effect of many cancer ch...
Glial tumor image-guided surgery and treatment
ABSTRACT In spite of huge clinical efforts, and a wealth of data on tumor biology, survival from glioma has not significantly changed in the last 25-years. Extent of resection rema...
Biological determinants of colorectal cancer outcomes in Latinos of diverseýancestral origins
ABSTRACT Hispanics/Latinos (Latinos) are the 2nd largest and fastest growing ethnic group in the United States.Although typically grouped as a single ethnic minority, Latinos are a...
The COVID-19 and Cancer Consortium: NCI Administrative Supplement to P30 Cancer Center Support Grant (CCSG)
Project Summary COVID-19, the disease caused by the SARS-coV-2 virus, has now affected nearly 100 million people globally, with nearly 2 million deaths. Patients with cancer have a...
Dietary Regulation of Colon Cancer Metastasis
Project Summary/Abstract Colorectal cancer (CRC) is the third most frequent cancer worldwide with increasing incidences every year. It is the leading cause of cancer related mortal...
Iron, Ferroptosis and Ovarian Cancer
Summary Ovarian cancer causes more deaths than any other gynecologic cancer in the US. The dismal prognosis of patients with advanced disease remains little changed in the past 30-...
Washington University PDX Development and Trial Center
Project Summary This application is being submitted in response to the Funding Opportunity Announcement (FOA) PA- 20-272.This supplemental proposal seeks to uncover the mechanism o...
Impact of the Breast Cancer Immune Microenvironment on Racial Disparities and Survivorship
PROJECT SUMMARY Breast cancer (BC) is the most commonly diagnosed malignancy and second leading cause of cancer-related deaths among women in the US.Among all BC cases, black women...