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20,252 grants found
Showing 17,721 – 17,740 of 20,252 grants
Cancer-prone cell states of the fallopian tubal epithelium
Project Summary Ovarian/extra-uterine high-grade serous carcinoma (HGSC) is the most common and aggressive type of ovarian cancer. It often has no symptoms at early stages and over...
Chromosome 1q ceRNAs in Melanoma Progression and Metastasis
PROJECT SUMMARY Metastasis is the main cause of deaths related to malignant melanoma. Studies over the last decade have revealed that the metastatic process is not primarily driven...
Improving treatment of HER2+ breast cancer brain metastasis by targeting lipid metabolism
ABSTRACT Patients with HER2 positive (HER2+) breast cancer (~14% of breast cancer patients) have a high risk of developing brain metastases (34%). The development of novel HER2 tar...
Drug eluting injectable biomaterials for next generation chemoembolization
Abstract Hepatocellular carcinoma (HCC), the most common type of liver cancer, is a major worldwide public health concern because it is often detected at advanced stages where trea...
Immunity to commensal papillomaviruses for cancer therapy
Project Summary/Abstract: Research in the field of microbiome has largely focused on the beneficial effects of commensal bacteria in regulating tissue homeostasis and the immune re...
Dual function of HSP70 in cytoprotection of tumor cells and generation of permissive microenvironment
It has been widely accepted that distinct epithelial to mesenchymal transition (EMT) phenotype and cancer stem cell (CSC) properties as well as the immunosuppressive tumor microenv...
SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer
Head and neck cancers (HNCs) account for nearly 3% of all cancers in the U.S. and most commonly affect aging individuals. While chemo-radiotherapy is the standard treatment approac...
The transcriptional and epigenetic landscape of cell fate changes in murine pancreatic cancer initiation and metastasis
Project Summary Pancreatic cancer, the fourth most lethal cancer in the United States and rising, represents 3% of all cancer cases diagnosed per year but a disproportionate 8% of...
A Registry-Based Study of Patterns of Use of Targeted Therapies for Metastatic Cancers in Diverse Populations
One of the most important cancer care advances in recent history is the rapid dissemination of targeted therapies (molecularly targeted kinase inhibitors and immune checkpoint inhi...
Microfluidic tumor tissue processing platform for single cell diagnostics
ABSTRACT Solid tumors are diverse ecosystems of different cell types, and this heterogeneity has been implicated as a key factor driving disease progression, metastasis, and drug r...
A high-throughput platform to identify selective allosteric inhibitors of the PLC-y isozymes
ABSTRACT The two PLC-gamma isozymes (PLC-gamma1, -gamma2) are central to the relay and amplification of signals originating from numerous receptor tyrosine kinases and immune recep...
Chromosome 1q ceRNAs in Melanoma Progression and Metastasis
PROJECT SUMMARY Metastasis is the main cause of deaths related to malignant melanoma. Studies over the last decade have revealed that the metastatic process is not primarily driven...
Identifying the active factor of an anti-inflammatory chemopreventive bacterium
Project Abstract/Summary Colorectal cancer (CRC) remains a major public health issue, with approximately 145,000 new cases and 51,000 deaths from this disease per year in the US al...
Investigating contributions of BRCA2 DNA-binding domains toward maintaining genome integrity
ABSTRACT Conserved mechanisms exist to eliminate DNA damage, which, if left unrepaired, can cause gene mutations and genome rearrangements to trigger neoplastic cell transformation...
Dual function of HSP70 in cytoprotection of tumor cells and generation of permissive microenvironment
It has been widely accepted that distinct epithelial to mesenchymal transition (EMT) phenotype and cancer stem cell (CSC) properties as well as the immunosuppressive tumor microenv...
Reduction of Tumor-Positive Margins in Oncology Surgery
Project Abstract Approximately 80% of early stage head and neck tumors undergo surgery of curative intent at some point in their treatment course. The success of this oncologic sur...
Integrative molecular dissection of acquired resistance to PD1/PD-L1 blockade in localized and metastatic urothelial carcinoma
Project Summary/Abstract Metastatic urothelial carcinoma (mUC) is generally incurable with modest survival benefit provided by first-line cisplatin-based chemotherapy and post-plat...
Defining the role of Taiman, the Drosophila homolog of AIB1, as a super-competitor in developing epithelia
PROJECT SUMMARY Invasive breast cancer is a deadly disease, killing ~42,000 women each year and costing the United States over $16.5 billion annually.The complicated disease mechan...
Development of nanoparticulate solution for cancer treatment by breakup of tumor extracellular hydroxyapatite: a new paradigm
Hydroxyapatite (HAP), Ca10(PO4)6OH2, once thought to be solely an ubiquitous component of bone, has not only been shown to be directly produced by breast malignancies.We have expan...
Repurposing Leflunomide to Delay Progression of Smoldering Multiple Myeloma in African Americans
PROJECT SUMMARY Smoldering multiple myeloma (SMM) is an asymptomatic precursor of active multiple myeloma (MM), and 50 percent of patients meeting criteria for high-risk disease wi...