Browse All Grants
20,252 grants found
Showing 17,701 – 17,720 of 20,252 grants
Understanding the Role of Macrophages and Iron in the Tumor Microenvironment
PROJECT SUMMARY/ABSTRACT Glioblastoma is one of the most aggressive and hard to treat human cancers facing modern medicine.The current standard of care for a new diagnosis of gliob...
Melanoma NAMPT mediates resistance to the anti-proliferative effects of Interferons (IFNs) and IFN based immunotherapies such as STING Agonists
Project Abstract Immune cells infiltrate the tumor microenvironment (TME) and secrete inflammatory cytokines such as interferons (IFNs) in order to drive anti-tumor responses and t...
Applying pathomics to establish a biosignature for aggressive skin melanoma.
PROJECT SUMMARY We propose to develop a pathomics biosignature for aggressive melanoma to guide treatment decisions for patients who have had a melanoma surgically removed but rema...
Copper-mediated metabolic reprogramming and ECM alterations in TNBC metastasis
Triple negative breast cancer (TNBC) patients present a formidable clinical challenge, as they exhibit higher rates of metastatic recurrence, and respond poorly to available target...
Identifying therapeutic pathways targeting medulloblastoma-immune cell interactions
SUMMARY We propose developing a systems-biology approach to understand interactions between tumor and immune cells and their clinical implications. Our work will focus on medullobl...
Regulatory Crosstalk Between Human Endogenous Retroviruses, HIV, and EBV, in Lymphoma
PROJECT SUMMARY/ABSTRACT Approximately 8% of the human genome is composed of sequences directly derived from germline infections of diverse retroviruses, which have accumulated ove...
Targeting purine biosynthesis to radiosensitize glioblastoma
Project Summary/Abstract Glioblastoma (GBM) is the most common aggressive primary brain tumor and is uniformly fatal with a median survival of around 1.5-years.Like surgery and che...
Support of the North American Association of Central Cancer Registries, Inc. (NAACCR) Annual Scientific Conference
NAACCR Annual Scientific Conference Project Summary R13 20-207 Cancer surveillance data are the lynchpin of the cancer data ecosystem.Only through the collection of accurate, stand...
Stat4Onc Annual Symposium
Project Summary/Abstract Cancer is the 2nd leading cause of death in US.Statistical designs and data analytics approaches are instrumental in recent development of more effective t...
Integrative genomic and epigenomic analysis of cancer using long read sequencing
PROJECT SUMMARY The last twenty years have experienced extensive growth in the sequencing of cancer genomes, leading to a dramatically increased understanding of the role of geneti...
Support of the North American Association of Central Cancer Registries, Inc. (NAACCR) Annual Scientific Conference
NAACCR Annual Scientific Conference Project Summary R13 20-207 Cancer surveillance data are the lynchpin of the cancer data ecosystem. Only through the collection of accurate, stan...
Mechanistic investigations of microbiome-driven aryl hydrocarbon receptor activity and macrophage function in pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer- related death. This is attributable to the asymptomatic early stages of disease, the fibrotic nature...
Investigating contributions of BRCA2 DNA-binding domains toward maintaining genome integrity
ABSTRACT Conserved mechanisms exist to eliminate DNA damage, which, if left unrepaired, can cause gene mutations and genome rearrangements to trigger neoplastic cell transformation...
Project 3: Chromatin modifiers of BRCA-related DNA repair Pathways
PROJECT SUMMARY/ABSTRACT: Induction of a DNA break initiates DNA damage signaling pathways that lead to coordinated and dynamic modification of the local chromatin landscape, inclu...
Project 4: The BRCA Network in Medulloblastoma Responses to Replication Stress
The BRCA Network in Medulloblastoma Responses to Replication Stress (Project-4) Abstract: BRCA1 and BRCA2 are critical genes for the repair of DNA strand breaks (DSB) via homologou...
Administrative Core
ABSTRACT: The Administrative Core (Admin Core) of the program project “Mechanisms of the BRCA-network in Tumorigenesis and Therapeutic Response” will effectively manage all aspects...
Proteolysis-targeting chimera against BCL-XL inhibits breast cancer metastasis
Project Summary-Abstract Metastasis is the major cause of BrCa death. Most women with metastatic BrCa (stage IV) are treated mainly with systemic therapy such as hormone therapy (f...
Multi-scale modeling of glioma for the prediction of treatment response, treatment monitoring and treatment allocation
Project summary Computational multi-scale modeling is a growing area of research that aims to link whole slide images and radiographic iamges with multi-omics molecular profiles of...
Deciphering Mechanisms of Tumor-Stromal Interactions in Prostate Cancer
Project Summary/Abstract Prostate cancer (PC) affects 1 in 9 men and causes nearly 30,000 yearly deaths in the United States. Understanding the PC tumor microenvironment (TME) is e...
Microbiota, Metabolites, and Colon Neoplasia
Project Summary The human diet can positively or negatively impact cancer incidence, with plant-derived compounds – such as polyphenols – often exhibiting antioxidant cancer-preven...