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20,252 grants found
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Targeting Myeloid Cells to Mitigate Immune Effector Cell-Associated Neurotoxicity Syndrome in Large B-cell Lymphoma
Project Summary The unprecedented efficacy of chimeric antigen receptor (CAR) modified T cells, for the treatment of patients with relapsed or refractory large B-cell lymphoma (LBC...
Proteolysis-targeting chimera against BCL-XL inhibits breast cancer metastasis
Project Summary-Abstract Metastasis is the major cause of BrCa death.Most women with metastatic BrCa (stage IV) are treated mainly with systemic therapy such as hormone therapy (fo...
Discovery of H. pylori T cell epitopes unique to minority populations that could contribute to increased gastric cancer rates.
Helicobacter pylori (H. pylori) is a bacterial infection which can be eradicated from the human body by most antibiotics, though, resistance is on the rise.The pathogen seems to pl...
Video Intervention to Address Pre-Test Patient Education for Tumor Genomic Testing
PROJECT SUMMARY Thousands of patients are diagnosed with metastatic cancers each year and somatic (tumor) next generation sequencing (NGS) testing is increasingly important for the...
Mechanisms of Variant ER-alpha Function in Breast Cancer
PROJECT SUMMARY / ABSTRACT Estrogen receptor-alpha (ER), a member of the nuclear receptor family of transcription factors, drives proliferation of breast cancer cells and is expres...
Role of RABL6A-PP2A in neuroendocrine tumors
Project Summary / Abstract Neuroendocrine tumors (NETs) are incurable, clinically challenging malignancies that are rising in incidence. Although tumors grow slowly, they progress...
The role of chromatin remodeling factors in DNA double strand break repair
7. PROJECT SUMMARY/ABSTRACT Accurate DNA double strand break (DSB) repair is important to maintain chromosomal stability.In the absence of DSB repair, translocations, deletions, du...
Origins and functions of pancreatic cancer-associated fibroblasts
PROJECT SUMMARY/ABSTRACT The mechanisms underlying evolution of tumor-associated stroma remain poorly understood.In solid tumors featuring a prominent stromal reaction, an improved...
Targeting differential kinase domain dimerization of EGFR mutants
In this R03 application, the PI will develop an independent project in the Lemmon lab aimed at understanding the relative importance of mutation-induced dimerization (versus direct...
Simultaneous targeting of tumor cells and tumor associated macrophages by RNA nanovector
PROJECT SUMMARY/ABSTRACT Compared to other types of cancer that have benefited from considerable advances in therapy, therapeutic outcomes in glioblastoma (GBM) patients still rema...
Targeting Checkpoint Inhibition in Anti-Tumor Responses
PROJECT SUMMARY The goal of this project is to evaluate novel therapeutics that block PSGL-1 (P-selectin glycoprotein-1), which we identified as a key inhibitory receptor (IR) that...
Development of the next-generation GPU-based Monte Carlo simulation platform for radiation-induced DNA damage calculations
Project Summary Ionizing radiation (IR) is a critical component of modern medicine.When IR penetrates through the organism, it could depart its energy to the medium mainly through...
A Registry-Based Study of Patterns of Use of Targeted Therapies for Metastatic Cancers in Diverse Populations
One of the most important cancer care advances in recent history is the rapid dissemination of targeted therapies (molecularly targeted kinase inhibitors and immune checkpoint inhi...
Defining metabolic adaptations within the PDAC "arid" tumor microenvironment
PROJECT SUMMARY The goal of our proposal is to identify therapeutic vulnerabilities associated with nutrient-poor conditions in tumors.Pancreatic ductal adenocarcinoma (PDAC) remai...
Linking Genetic, Epigenetic and Signaling Mechanisms of Oncogene Addiction
PROJECT SUMMARY Our long-term goal is to build a network-level and single-cell understanding of the interplay between genetic, epigenetic and signaling mechanisms that determine th...
Prediagnostic exposures, germline genetics, and triple negative breast cancer mutational and immune profiles
Triple negative breast cancer (TNBC) are typically aggressive cancers with shorter median time to relapse and death than other breast cancers.Because these cancers are defined by t...
NFkB-dependent antiviral pathways in VSV-resistant cancer cells
Antiviral responses are defective in many human tumors, leaving them susceptible to infection by ?oncolytic? viruses such as vesicular stomatitis virus (VSV). In contrast, normal c...
Immunity to commensal papillomaviruses for cancer therapy
Project Summary/Abstract: Research in the field of microbiome has largely focused on the beneficial effects of commensal bacteria in regulating tissue homeostasis and the immune re...
CXCL5/CXCR2 axis as a therapeutic vulnerability of breast cancer metastasis to bone
PROJECT SUMMARY/ABSTRACT The majority of breast cancers express estrogen receptor a (ER+), a molecule that typically promotes cell proliferation when activated by its ligand estrog...
An Addictions Neuroclinical Assessment Based Treatment for Smokers with an Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT Together, tobacco and alcohol kill more than half a million people in the United States every year, making co- addiction to these substances the leading ca...