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20,252 grants found
Showing 17,661 – 17,680 of 20,252 grants
Inducing transcriptional reprogramming of leukemic B-cells by facilitating transcription factors binding to nascent decondensed chromatin
Project Summary/Abstract B cell acute lymphoblastic leukemia (B-ALL) consist of Leukemic Blast Cells (LBCs) that become arrested at distinct stages of B cell development because of...
Development of Rationally Designed Cancer Vaccines Using Protein-like Polymers (PLPs)
PROJECT SUMMARY The utilization of tumor antigens, which are antigenic peptides expressed in cancer cells as a result of random somatic mutations, for the development of patient-sp...
Development and Commercialization of a New Molecularly Targeted Imaging Agent for Multiple Myeloma
PROJECT SUMMARY Sarya LLC (Sarya) is a nuclear medicine technology company formed to commercialize radiopharmaceuticals.The goal of this Fast-Track STTR is to develop a new specifi...
PROTEAN-CR: Proteomics Toolkit for Ensemble Analysis in Cancer Research
Project Summary Understanding protein?ligand molecular interactions is fundamental to understanding the role of proteins in complex diseases such as cancer.For instance, there is g...
An Inducible Model for Studying Cancer Stem Cells in PDAC
Project Summary The Cancer Stem Cell (CSC) theory, which was first proposed more than four decades ago, states that a small population of cancer cells possess the characteristics a...
Deciphering Mechanisms of Tumor-Stromal Interactions in Prostate Cancer
Project Summary/Abstract Prostate cancer (PC) affects 1 in 9 men and causes nearly 30,000 yearly deaths in the United States. Understanding the PC tumor microenvironment (TME) is e...
Applying deep learning to predict T cell receptor binding specificity of neoantigens and response to checkpoint inhibitors
Project Summary Background: In-depth study of neoantigens will promote our knowledge of the fundamental mechanisms of basic immunology and immune-related disease processes, such as...
The Nathan Schnaper Intern Program in Translational Cancer Research
Significant progress in detection and treatment has reduced cancer mortality rates; however, with over 1.7 million new cases and 600,000 deaths from cancer reported in 2019, it rem...
Cancer-prone cell states of the fallopian tubal epithelium
Project Summary Ovarian/extra-uterine high-grade serous carcinoma (HGSC) is the most common and aggressive type of ovarian cancer.It often has no symptoms at early stages and over...
Mechanistic investigations of microbiome-driven aryl hydrocarbon receptor activity and macrophage function in pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer- related death.This is attributable to the asymptomatic early stages of disease, the fibrotic nature...
Contribution of Epigenome to PRKCI-Driven High-Grade Serous Ovarian Cancer
ABSTRACT Cancer cells acquire genetic and epigenetic alterations that increase fitness and drive progression through multiple steps of tumor evolution.Recent studies have vastly en...
Multimodality X-ray transmission and diffraction scanner for molecular analysis of cancer specimens
ABSTRACT Cancer research using biospecimens requires the analysis of samples with a large range of sizes (sub-mm to cm) and molecular composition over a wide range of length scales...
Paper-based Breastmilk Collection System for Facile, In-Home Use
This project will conduct early-stage development of a paper-based device to facilitate the efficient recovery of high-quality nucleic acids from breastmilk for use in breast cance...
B7-H3 CAR T cell-based immunotherapy combined with Losartan to counteract desmoplasia for the treatment of Pancreatic Ductal Adenocarcinoma (PDAC)
ABSTRACT The need for an effective therapy for pancreatic ductal adenocarcinoma (PDAC) has prompted us to develop a novel combinatorial immunotherapy with T cells engineered with a...
Building a reinforcement learning tool for individually tailoring just-in-time adaptive interventions: Extending the reach of mHealth technology for improved weight loss outcomes
Project Summary Excess weight is associated with 13 types of cancer.These cancers disproportionately affect Black and Latinx individuals, as well as those with lower socioeconomic...
Oncolytic Adenovirus Armed with SA-4-1BBL Immune Checkpoint Stimulator for Lung Cancer Immunotherapy
Project Summary Despite the clinical successes of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC), many patients experience resistance after an initial re...
Dissecting the immunological mechanisms associated with prostate cancer progression in African-American men and exploring epigenetics-based immune modulation for therapy
Project Summary Prostate Cancer (PCa) is a leading cause of cancer-related deaths among men in the United States.Within the general population, African-Americans, who constitute a...
Reversing molecular cancer phenotypes by targeting epigenetic alterations in prostate cancer
Project Summary/Abstract Molecular alterations that lead to variable clinical behavior and progression of prostate cancer are identified.Approximately 20% of prostate tumors includ...
Chemo-neoepitopes as novel immunotherapy for triple negative breast cancer
PROJECT SUMMARY/ABSTRACT We propose to create a library of chemotherapy-induced cancer neoepitopes (chemo-neoepitopes) that are shared between breast cancers, do not have to be cus...
Role of LMPTP in Prostate Cancer
ABSTRACT The objective of this proposal is to perform exploratory examination of the low molecular weight protein tyrosine phosphatase (LMPTP) as a new target for prostate cancer t...