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20,252 grants found
Showing 17,641 – 17,660 of 20,252 grants
Multimodality X-ray transmission and diffraction scanner for molecular analysis of cancer specimens
ABSTRACTCancer research using biospecimens requires the analysis of samples with a large range of sizes (sub-mm to cm) and molecular composition over a wide range of length scales....
Role of RABL6A-PP2A in neuroendocrine tumors
Project Summary / Abstract Neuroendocrine tumors (NETs) are incurable, clinically challenging malignancies that are rising in incidence. Although tumors grow slowly, they progress...
Defining metabolic adaptations within the PDAC "arid" tumor microenvironment
PROJECT SUMMARY The goal of our proposal is to identify therapeutic vulnerabilities associated with nutrient-poor conditions in tumors. Pancreatic ductal adenocarcinoma (PDAC) rema...
Applying pathomics to establish a biosignature for aggressive skin melanoma
PROJECT SUMMARY We propose to develop a pathomics biosignature for aggressive melanoma to guide treatment decisions for patients who have had a melanoma surgically removed but rema...
Investigating contributions of BRCA2 DNA-binding domains toward maintaining genome integrity
ABSTRACT Conserved mechanisms exist to eliminate DNA damage, which, if left unrepaired, can cause gene mutations and genome rearrangements to trigger neoplastic cell transformation...
A high-throughput platform to identify selective allosteric inhibitors of the PLC-y isozymes
ABSTRACTThe two PLC-gamma isozymes (PLC-gamma1, -gamma2) are central to the relay and amplification of signals originating from numerous receptor tyrosine kinases and immune recept...
Radiomics and Pathomics to predict upstaging of DCIS
Abstract Ductal carcinomas in situ (DCIS) of the breast are a heterogeneous group of neoplastic lesions that are usually detected by screening mammography.Workup generally includes...
SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer
Head and neck cancers (HNCs) account for nearly 3% of all cancers in the U.S. and most commonly affect aging individuals.While chemo-radiotherapy is the standard treatment approach...
Role of ALDH in PARP inhibitor resistance in HR-deficient ovarian cancer
Summary Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are an exciting and promising new class of anticancer drugs, which have been approved by the FDA for recurrent ovaria...
Mechanisms of the BRCA-network in tumorigenesis and therapeutic response
Mechanisms of the BRCA-network in Tumorigenesis and Therapeutic Response (OVERALL) Abstract: The faithful repair of DNA damage and efficient resolution of stalled replication forks...
Project 1: Recruitment of the BRCA1-associated Homologous Recombination Machinery
PROJECT SUMMARY: ?RECRUITMENT OF THE BRCA1-ASSOCIATED HOMOLOGOUS RECOMBINATION MACHINERY? A substantial proportion of tumors show patterns of mutation that arise because of problem...
An information-theoretic approach to HP signal acquisition in brain
Project Summary Dissolution dynamic nuclear polarization can be used to enhance the MRI signal from [1-13C]-pyruvate by 4-5 orders of magnitude compared to thermal equilibrium, ena...
Infectious pressures on cell competition and cooperation during leukemia initiation
PROJECT SUMMARY Myelodysplastic-syndrome (MDS) is a cancer of stem cells that form the blood.In MDS, abnormal stem cells accumulate but are unable to make enough functional blood c...
Validating Urine Derived Cancer Cells (UDCC) -- Non-Invasive and Living Liquid Biopsies -- in Bladder Cancer Clinics
PROJECT SUMMARY Bladder cancer (BC) is the costliest cancer (per case) among all cancer types and yet among the top 10 cancers it is the most underfunded cancer by NCI.There has be...
Multi-scale modeling of glioma for the prediction of treatment response, treatment monitoring and treatment allocation
Project summary Computational multi-scale modeling is a growing area of research that aims to link whole slide images and radiographic iamges with multi-omics molecular profiles of...
Intratumoral Heterogeneity and Plasticity in Basal-Like Breast Cancers
Project Summary Triple Negative Breast Cancer (TNBC) is an aggressive malignancy with a poor prognosis that accounts for 10- 20% of breast cancer cases worldwide.Tumor resistance t...
Improving treatment of HER2+ breast cancer brain metastasis by targeting lipid metabolism
ABSTRACT Patients with HER2 positive (HER2+) breast cancer (~14% of breast cancer patients) have a high risk of developing brain metastases (34%).The development of novel HER2 targ...
Multiethnic GWAS and TWAS to Inform Risk Prediction for Prostate Cancer
Abstract Prostate cancer (PCa) incidence is highest in African Americans and lowest in Asians. These long-standing racial/ethnic differences have yet to be explained.Genome-wide as...
Integrative genomic and epigenomic analysis of cancer using long read sequencing
PROJECT SUMMARY The last twenty years have experienced extensive growth in the sequencing of cancer genomes, leading to a dramatically increased understanding of the role of geneti...
The transcriptional and epigenetic landscape of cell fate changes in murine pancreatic cancer initiation and metastasis
Project Summary Pancreatic cancer, the fourth most lethal cancer in the United States and rising, represents 3% of all cancer cases diagnosed per year but a disproportionate 8% of...