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20,252 grants found
Showing 17,621 – 17,640 of 20,252 grants
Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance
PROJECT SUMMARY Prostate cancer (PCa) is the most commonly diagnosed cancer among American men and metastatic Castration- Resistant Prostate Cancer (mCRPC) is the mostly deadly for...
Determining mechanisms of PRC2-mediated disease using Drosophila
PROJECT ABSTRACT/SUMMARY Normal development requires tightly controlled gene expression to precisely regulate tissue patterning and failure to properly control the expression profi...
Applying pathomics to establish a biosignature for aggressive skin melanoma
PROJECT SUMMARY We propose to develop a pathomics biosignature for aggressive melanoma to guide treatment decisions for patients who have had a melanoma surgically removed but rema...
Integrative genomic and epigenomic analysis of cancer using long read sequencing
PROJECT SUMMARY The last twenty years have experienced extensive growth in the sequencing of cancer genomes, leading to a dramatically increased understanding of the role of geneti...
Universal Sample Multiplexing for Single Cell Analysis
ABSTRACT Cancer progression and resistance to therapy are strongly influenced by tumor heterogeneity. Single-cell RNA sequencing (scRNAseq) is a valuable tool for cancer research b...
Mechanisms of the BRCA-network in tumorigenesis and therapeutic response
Mechanisms of the BRCA-network in Tumorigenesis and Therapeutic Response (OVERALL) Abstract: The faithful repair of DNA damage and efficient resolution of stalled replication forks...
Project 1: Recruitment of the BRCA1-associated Homologous Recombination Machinery
PROJECT SUMMARY: “RECRUITMENT OF THE BRCA1-ASSOCIATED HOMOLOGOUS RECOMBINATION MACHINERY” A substantial proportion of tumors show patterns of mutation that arise because of problem...
Project 2: Targeting DNA replication in BRCA-associated breast cancer
PROJECT SUMMARY Germline mutations in BRCA1 and BRCA2 and PALB2 predispose to breast cancer and also increase the risks of ovarian, pancreatic, prostate, and other cancers. The pro...
Project 3: Chromatin modifiers of BRCA-related DNA repair Pathways
PROJECT SUMMARY/ABSTRACT: Induction of a DNA break initiates DNA damage signaling pathways that lead to coordinated and dynamic modification of the local chromatin landscape, inclu...
Project 4: The BRCA Network in Medulloblastoma Responses to Replication Stress
The BRCA Network in Medulloblastoma Responses to Replication Stress (Project-4) Abstract: BRCA1 and BRCA2 are critical genes for the repair of DNA strand breaks (DSB) via homologou...
Administrative Core
ABSTRACT: The Administrative Core (Admin Core) of the program project “Mechanisms of the BRCA-network in Tumorigenesis and Therapeutic Response” will effectively manage all aspects...
Core 1: Mouse and Cell Modeling
PROJECT SUMMARY (Core-1) Genetically engineered cell lines and mouse models are critical for elucidating complex biological processes. The ability to customize the context in which...
Core 2: Genomics
ABSTRACT The Genomics Core (Core 2) will provide support with genomics profiling and integrative bioinformatics analysis support for all the four projects, contributing towards the...
Targeting purine biosynthesis to radiosensitize glioblastoma
Project Summary/Abstract Glioblastoma (GBM) is the most common aggressive primary brain tumor and is uniformly fatal with a median survival of around 1.5-years. Like surgery and ch...
A high-throughput platform to identify selective allosteric inhibitors of the PLC-y isozymes
ABSTRACTThe two PLC-gamma isozymes (PLC-gamma1, -gamma2) are central to the relay and amplification of signals originating from numerous receptor tyrosine kinases and immune recept...
Linking Genetic, Epigenetic and Signaling Mechanisms of Oncogene Addiction
PROJECT SUMMARY Our long-term goal is to build a network-level and single-cell understanding of the interplay between genetic, epigenetic and signaling mechanisms that determine th...
Administrative Supplement to Support Collaborations to Improve AIML-Readiness of NIH-Supported Data for Parent Award SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer
Project Summary We have collected, under our parent award (1R01CA257814-01), a database of serial multi-parametric magnetic resonance (MR) images as well as patient-reported and ob...
Diversity Supplement: SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head and Neck Cancer
Project Summary No changes from original grant R01CA257814.
Diversity Supplement: SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head and Neck Cancer
Project Summary No changes from original grant R01CA257814.
SEER CORE INFRASTRUCTURE SUPPORT
The purpose of the National Cancer Institute (NCI) Surveillance Epidemiology and End Results (SEER) Program is to assemble and report annual estimates of cancer statistics that per...