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20,252 grants found
Showing 17,601 – 17,620 of 20,252 grants
Validating Urine Derived Cancer Cells (UDCC) -- Non-Invasive and Living Liquid Biopsies -- in Bladder Cancer Clinics
PROJECT SUMMARY Bladder cancer (BC) is the costliest cancer (per case) among all cancer types and yet among the top 10 cancers it is the most underfunded cancer by NCI. There has b...
Investigation of the mitochondrial function in GNAS mutant neoplasms
Emerging evidences pointing out the requirement of mitochondrial function in the oncogenesis processes, but how the mitochondrial state is changed in different set of oncogenic mut...
Avanzando Caminos (Leading Pathways): The Hispanic/Latino Cancer Survivorship Cohort Study.”
Project Summary Cancer is the leading cause of death among Hispanics/Latinos (H/Ls) in the US. H/Ls account for 57.5 million Americans (18%), now the largest minority expected to d...
Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance
PROJECT SUMMARY Prostate cancer (PCa) is the most commonly diagnosed cancer among American men and metastatic Castration- Resistant Prostate Cancer (mCRPC) is the mostly deadly for...
Linking Genetic, Epigenetic and Signaling Mechanisms of Oncogene Addiction
PROJECT SUMMARY Our long-term goal is to build a network-level and single-cell understanding of the interplay between genetic, epigenetic and signaling mechanisms that determine th...
Mechanisms of Variant ER-alpha Function in Breast Cancer
PROJECT SUMMARY / ABSTRACT Estrogen receptor-alpha (ER), a member of the nuclear receptor family of transcription factors, drives proliferation of breast cancer cells and is expres...
PROTEAN-CR: Proteomics Toolkit for Ensemble Analysis in Cancer Research
Project Summary Understanding protein–ligand molecular interactions is fundamental to understanding the role of proteins in complex diseases such as cancer. For instance, there is...
Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer
Project Summary/Abstract The ultimate goal of this mPI proposal is to address a fundamental gap in knowledge on the role of acetyl-CoA metabolic reprogramming in regulating cyclin...
CXCL5/CXCR2 axis as a therapeutic vulnerability of breast cancer metastasis to bone
PROJECT SUMMARY/ABSTRACT The majority of breast cancers express estrogen receptor a (ER+), a molecule that typically promotes cell proliferation when activated by its ligand estrog...
Clinical Utility of Biomarkers Driven Management of Indeterminate Pulmonary Nodules
PROJECT SUMMARY The goal of this application is to test the clinical utility of a biomarker-informed approach to the evaluation and management of indeterminate pulmonary nodules (I...
Regulatory Crosstalk Between Human Endogenous Retroviruses, HIV, and EBV, in Lymphoma
PROJECT SUMMARY/ABSTRACT Approximately 8% of the human genome is composed of sequences directly derived from germline infections of diverse retroviruses, which have accumulated ove...
An Addictions Neuroclinical Assessment Based Treatment for Smokers with an Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT Together, tobacco and alcohol kill more than half a million people in the United States every year, making co- addiction to these substances the leading ca...
Copper-mediated metabolic reprogramming and ECM alterations in TNBC metastasis
Triple negative breast cancer (TNBC) patients present a formidable clinical challenge, as they exhibit higher rates of metastatic recurrence, and respond poorly to available target...
A high-throughput platform to identify selective allosteric inhibitors of the PLC-y isozymes
ABSTRACTThe two PLC-gamma isozymes (PLC-gamma1, -gamma2) are central to the relay and amplification of signals originating from numerous receptor tyrosine kinases and immune recept...
Universal Sample Multiplexing for Single Cell Analysis
ABSTRACT Cancer progression and resistance to therapy are strongly influenced by tumor heterogeneity. Single-cell RNA sequencing (scRNAseq) is a valuable tool for cancer research b...
Defining the role of Taiman, the Drosophila homolog of AIB1, as a super-competitor in developing epithelia
PROJECT SUMMARY Invasive breast cancer is a deadly disease, killing ~42,000 women each year and costing the United States over $16.5 billion annually. The complicated disease mecha...
Development of Rationally Designed Cancer Vaccines Using Protein-like Polymers (PLPs)
PROJECT SUMMARY The utilization of tumor antigens, which are antigenic peptides expressed in cancer cells as a result of random somatic mutations, for the development of patient-sp...
Decoupling Bidirectional EphB/ephrinB2 in Multiple Myeloma
Project Summary/Abstract My research objectives are to study the impact of decoupling the EphB4/ephrinB2 axis in multiple myeloma (MM), a cancer of antibody-secreting plasma cells,...
Inducing transcriptional reprogramming of leukemic B-cells by facilitating transcription factors binding to nascent decondensed chromatin
Project Summary/Abstract B cell acute lymphoblastic leukemia (B-ALL) consist of Leukemic Blast Cells (LBCs) that become arrested at distinct stages of B cell development because of...
Prediagnostic exposures, germline genetics, and triple negative breast cancer mutational and immune profiles
Triple negative breast cancer (TNBC) are typically aggressive cancers with shorter median time to relapse and death than other breast cancers. Because these cancers are defined by...