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20,252 grants found
Showing 1,741 – 1,760 of 20,252 grants
Advancing the Science of Cancer in Latinos 2024
Project Summary/Abstract The Institute for Health Promotion Research (IHPR) and the Mays Cancer Center, an NCI-designated cancer center at UT Health San Antonio, partner closely to...
Mitochondrial bioenergetics and colorectal cancer
ABSTRACT Relative to matched normal tissue, recent large scale sequencing efforts indicate that colorectal cancer (CRC) tumors are specifically enriched in loss of function mutatio...
Mitochondrial bioenergetics and colorectal cancer
ABSTRACT Relative to matched normal tissue, recent large scale sequencing efforts indicate that colorectal cancer (CRC) tumors are specifically enriched in loss of function mutatio...
Identifying non-cardiotoxic drug combinations for patients with relapsed sarcoma
Summary Standard-of-care treatments for most sarcomas and other childhood cancers include high-doses of anthracyclines, in particular doxorubicin (DOXO). DOXO causes irreparable da...
Expanding the targetable landscape in cancer with serine-targeting covalent ligands
Project Summary Targeted covalent inhibitors have empowered the potent and selective targeting of driver oncogenes in cancer. Between 2011 and 2021, 16 new covalent drugs (12 with...
Selective targeting of TAF1 function in acute myeloid leukemia
PROJECT SUMMARY Although dysregulated gene transcription is a major contributing factor in cancer, the development of drugs interfering with general transcription remains a challen...
2024 SBIR CONCEPT CLEARANCE AWARD
Positron emission tomography (PET), a sensitive functional imaging technique, holds potential for diagnosing and monitoring medical conditions. Its use in pediatric oncology is hin...
Developing biomarkers of response for a new therapy in ovarian cancer
PROJECT SUMMARY Clear cell ovarian cancer (CCOC) is one of the most challenging subtypes of ovarian cancer (OVCA) to treat, as it is resistant to standard chemotherapy and is assoc...
Immunotherapy of prostate cancer using an anti-CD6 monoclonal antibody
PROJECT SUMMARY/ABSTRACT Limitations of checkpoint inhibitor cancer treatment include precipitation of autoimmunity and resistance to immunotherapy. For some cancers, notably prost...
Cancer Screening Research Network - North Carolina Hub (CSRN-NC HUB)
PROJECT SUMMARY/ABSTRACT Although evidence-based cancer screening protocols exist for several common cancer types, an estimated 70% of cancer deaths are due to cancers for which no...
Multi-Ethnic Multi-Cancer Early Detection and Screening (MED SCREEN) Study
Project Summary Multi-cancer detection (MCD) tests, which evaluate cell-free DNA and other biological components with a single blood draw, are a new frontier in cancer screening, p...
CONCEPT SBIR - T-CELL RECEPTORS FOR TREATING PEDIATRIC ACUTE MYELOID LEUKEMIA
More than 30% of children diagnosed with acute myeloid leukemia (AML) relapse after initial treatment, creating an urgent need for new treatment options.T-cell receptor (TCR) based...
Phase I Therapeutic Award - Developing Split, Conditionally Active Peptidomimetics of IL-12 For the Treatment of Rare Pediatric DIPG
Diffuse intrinsic pontine glioma (DIPG) is a rare, universally fatal childhood brainstem tumor, striking about 150-300 children in the US with a median survival of only 9-11 months...
SBIR CONCEPT AWARD - THERAPEUTICS - SULFONYL-UREA AND SULFONAMIDE PP2A ACTIVATORS AS MYCN AMPLIFIED NEUROBLASTOMA (NBL) THERAPEUTICS
The five year survival of children with refractory or relapsed neuroblastoma (NBL), often with MYCN amplified tumors, is only about 10%, and the outcome for this subset of patients...
SBIR CONCEPT AWARD "THERAPEUTICS" - TARGETED DELIVERY OF FERROPTOSIS INDUCERS FOR TREATMENT OF ADRENOCORTICAL CARCINOMA
This proposal seeks to develop a novel therapeutic approach for recurrent or metastatic adrenocortical carcinoma (ACC), a rare and aggressive malignancy of the adrenal cortex. The...
Ultrasound-based Diagnosis and Monitoring of Neutropenic Enterocolitis in Children with Acute Lymphoblastic Leukemia
Acute lymphocytic leukemia, a blood cancer, is most common among children under five and is treated with chemotherapy.Neutropenic enterocolitis (NEC) is a life-threatening complica...
SBIR FY24 CONCEPT AWARD-DRUG REPURPOSING FOR RARE CANCERS USING A LARGE-SCALE, HIGH-QUALITY BIOMEDICAL KNOWLEDGE GRAPH
This proposal aims to advance drug repurposing for rare cancers by utilizing cutting-edge computational approaches. The long-term objectives are to discover effective treatments fo...
2024 SBIR CONCEPT CLEARANCE AWARD
Oral cancer remains a life-threatening disease with 11,580 deaths in the US each year. Surgery provides the best chance of survival and is the preferred treatment option for oral c...
Exploiting Lineage-Specific Dependencies in Solid Tumors: Using Transcription Factors to Drive Therapeutic Effect In Situ
Many cancers exhibit aberrant overexpression of developmental lineage-specific transcription factors.In this project we investigate the potential of exploiting oncogenic overexpres...
Aberrant V(D)J recombination in B cells initiates lymphoid malignancy
PROJECT SUMMARY/ABSTRACT Chromosomal translocations occur in nearly all human lymphoid neoplasms, many the result of aberrant repair of DNA double-stand breaks (DSBs) generated in...