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20,252 grants found
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Engaging immunosuppressive myeloid cells in the TME for the treatment of pancreatic cancer
ABSTRACT Although the past decade was marked by the tremendous success of immunotherapeutics in oncology, few have provided significant benefit to patients with pancreatic cancer....
rPIV5- and AVLP-vectored vaccine development with public tumor-specific neoantigens
Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 23-045. The proposed supplement project aims to validate the...
Canine MHC-I genotyping and tumor specific neoantigen determination
Abstract Being naturally occurring and with an intact immune system, spontaneous cancers in pet dogs have the potential to effectively bridge a current gap between preclinical mode...
Engaging immunosuppressive myeloid cells in the TME for the treatment of pancreatic cancer
ABSTRACT Although the past decade was marked by the tremendous success of immunotherapeutics in oncology, few have provided significant benefit to patients with pancreatic cancer....
TNBC Ligand-displaying Exosomes Using RNA Nanotechnology for Targeted Cytosol Delivery of RNAi without Endosome Entrapment
SUMMARY Triple negative breast cancer (TNBC) is a heterogeneous, complex, and aggressive breast cancer subtype. TNBC patients respond poorly to chemotherapy, leading to high mortal...
(PQ4) Role of HIV-induced PLK1 Activation in Regulation of gamma-Herpesvirus Reservoirs in Lymphocytes
PROJECT SUMMARY Gammaherpesvirus infections are associated with a number of malignancies that include B-cell lymphoproliferative diseases, gastric carcinoma, nasopharyngeal carcino...
AI Transfer of the MHC-I Immunopeptidome from Human to Dog
Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-029. It is submitted as a supplement to our parent R01CA2...
Investigating the mechanisms of driver genes associated with ancestry and aggressiveness in prostate cancer
Summary African American (AA) men have the highest incidence and mortality rate from prostate cancer in the United States. We recently showed that AA men with low-risk prostate can...
Survivorship and Access to care for Latinos to Understand and address Disparities (SALUD)
ABSTRACT Pediatric cancer survivors (PCS) experience an excess risk of adverse outcomes related to their cancer diagnosis and the treatment they receive. The accumulation and sever...
Cancer Grand Challenges: Operations Management Application
Cancer Research UK (CRUK) established its ‘Grand Challenge’ initiative in 2015 to support international, interdisciplinary teams of elite scientists and clinicians to address some...
Investigating the mechanisms of driver genes associated with ancestry and aggressiveness in prostate cancer
Summary African American (AA) men have the highest incidence and mortality rate from prostate cancer in the United States. We recently showed that AA men with low-risk prostate can...
Survivorship and Access to care for Latinos to Understand and address Disparities (SALUD)
ABSTRACT Pediatric cancer survivors (PCS) experience an excess risk of adverse outcomes related to their cancer diagnosis and the treatment they receive. The accumulation and sever...
Cancer Grand Challenges: Operations Management Application
Cancer Research UK (CRUK) established its ‘Grand Challenge’ initiative in 2015 to support international, interdisciplinary teams of elite scientists and clinicians to address some...
Survivorship and Access to care for Latinos to Understand and address Disparities (SALUD)
ABSTRACT Pediatric cancer survivors (PCS) experience an excess risk of adverse outcomes related to their cancer diagnosis and the treatment they receive.The accumulation and severi...
Investigating the mechanisms of driver genes associated with ancestry and aggressiveness in prostate cancer
Summary African American (AA) men have the highest incidence and mortality rate from prostate cancer in the United States. We recently showed that AA men with low-risk prostate can...
Interaction of HTLV-1 Tax & Hbz in Transformation
Interaction of HTLV-1 Tax & Hbz in Transformation Abstract Human T-cell leukemia virus type 1 (HTLV-1) is the cause of a refractory T cell lymphoproliferative disorder, designa...
Survivorship and Access to care for Latinos to Understand and address Disparities (SALUD)
ABSTRACT Pediatric cancer survivors (PCS) experience an excess risk of adverse outcomes related to their cancer diagnosis and the treatment they receive. The accumulation and sever...
RNASEH2B loss to predict response to PARP inhibitor in prostate cancer
ABSTRACT Metastatic castration-resistant prostate cancer (CRPC) is an incurable disease that is expected to account for ~ 31,000 deaths each year in the United States. There are li...
Cancer Grand Challenges: Operations Management Application
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Interaction of HTLV-1 Tax & Hbz in Transformation
Interaction of HTLV-1 Tax & Hbz in Transformation Abstract Human T-cell leukemia virus type 1 (HTLV-1) is the cause of a refractory T cell lymphoproliferative disorder, designa...