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20,252 grants found
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Positive Affect, Future Thinking, and Planning: Testing Brief Intervention Components to Optimize a Novel Intervention to Promote Physical Activity
Project Summary Insufficient levels of regular physical activity (< 150 minutes/week of moderate-to-vigorous physical activity [MVPA]) are associated with various health risks,...
Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapy
ABSTRACT Despite recent progress in immunotherapy (checkpoint blockade and adoptive T cell transfer), most patients with solid tumors still do not respond or subsequently develop a...
Flow Responsive Embolic Agent for the Complete Devascularization of Meningiomas
PROJECT SUMMARY Significance: Pre-operative embolization (POE) of meningiomas is an established neuroendovascular procedure performed to reduce the extensive amount of blood loss t...
TO PROVIDE THE DENOMINATOR DATA REQUIRED FOR THE NCI TO RELEASE CANCER RATES BY SINGLE RACE AND ETHNICITY AMONG IMMIGRANTS AND EASY-TO-ACCESS ACS SAMP
The study of racial disparities in cancer incidence and mortality rates among immigrants requires population data by immigration status and single-race categories.The American Comm...
Clinical & Mechanistic underpinnings to reducing PAX:FOXO1 for alveolar rhabdomyosarcoma
SUMMARY The childhood muscle cancer alveolar rhabdomyosarcoma (ARMS) is generally not survivable when metastatic. However, ARMS does usually respond clinically to chemotherapy init...
Cellular interactions between TGF-beta pathway members and epignetic regulators in liver and gastrointestinal cancers
Contact PD/PI: Mishra, Lopa Project-001 (001) ABSTRACT Transforming Growth Factor-Beta (TGF-β) is a potent regulator of stem cell differentiation, epigenetic alterations, inflammat...
Clinical & Mechanistic underpinnings to reducing PAX:FOXO1 for alveolar rhabdomyosarcoma
SUMMARY The childhood muscle cancer alveolar rhabdomyosarcoma (ARMS) is generally not survivable when metastatic. However, ARMS does usually respond clinically to chemotherapy init...
Clinical & Mechanistic underpinnings to reducing PAX:FOXO1 for alveolar rhabdomyosarcoma
SUMMARY The childhood muscle cancer alveolar rhabdomyosarcoma (ARMS) is generally not survivable when metastatic. However, ARMS does usually respond clinically to chemotherapy init...
Clinical & Mechanistic underpinnings to reducing PAX:FOXO1 for alveolar rhabdomyosarcoma
SUMMARY The childhood muscle cancer alveolar rhabdomyosarcoma (ARMS) is generally not survivable when metastatic. However, ARMS does usually respond clinically to chemotherapy init...
Adaptive randomized designs for cancer clinical trials by using integer algorithms and exact Monte Carlo methods
Project Summary/Abstract Current phase II clinical trial designs for cancer studies are generally not flexible and effective enough to reduce sample size and costs. Unlike tradition...
Cellular interactions between TGF-beta pathway members and epignetic regulators in liver and gastrointestinal cancers
Contact PD/PI: Mishra, Lopa Project-001 (001) ABSTRACT Transforming Growth Factor-Beta (TGF-?) is a potent regulator of stem cell differentiation, epigenetic alterations, inflammat...
Adaptive randomized designs for cancer clinical trials by using integer algorithms and exact Monte Carlo methods
Project Summary/Abstract Current phase II clinical trial designs for cancer studies are generally not ?exible and effective enough to reduce sample size and costs.Unlike traditiona...
Novel Bisphosphonate PET Probes for Myeloma Bone Disease
PROJECT SUMMARY/ABSTRACT Multiple myeloma (MM), a malignancy of mature plasma cells, is the second most common hematologic malignancy. Myeloma bone disease (MBD) is a devastating c...
Epigenetic contribution to the excess risk of MGUS in African Americans
ABSTRACT The goal of this investigation is to characterize the influence of the DNA methylome central to the increased risk of Monoclonal Gammopathy of Undetermined Significance (M...
Epigenetic contribution to the excess risk of MGUS in African Americans
ABSTRACT The goal of this investigation is to characterize the influence of the DNA methylome central to the increased risk of Monoclonal Gammopathy of Undetermined Significance (M...
Novel Bisphosphonate PET Probes for Myeloma Bone Disease
PROJECT SUMMARY/ABSTRACT Multiple myeloma (MM), a malignancy of mature plasma cells, is the second most common hematologic malignancy. Myeloma bone disease (MBD) is a devastating c...
Epigenetic contribution to the excess risk of MGUS in African Americans
ABSTRACT The goal of this investigation is to characterize the influence of the DNA methylome central to the increased risk of Monoclonal Gammopathy of Undetermined Significance (M...
Novel Bisphosphonate PET Probes for Myeloma Bone Disease
PROJECT SUMMARY/ABSTRACT Multiple myeloma (MM), a malignancy of mature plasma cells, is the second most common hematologic malignancy. Myeloma bone disease (MBD) is a devastating c...
Epigenetic contribution to the excess risk of MGUS in African Americans
ABSTRACT The goal of this investigation is to characterize the influence of the DNA methylome central to the increased risk of Monoclonal Gammopathy of Undetermined Significance (M...
Tumor Intrinsic Regulation of Immune Evasion Pathways in Breast Cancer
Project Summary/Abstract: The incidence rate of cutaneous melanoma has doubled since 1973, and is increasing more rapidly than any other cancer.FDA-approved targeted inhibitors and...