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20,252 grants found
Showing 17,421 – 17,440 of 20,252 grants
Expanding the Druggable Human Genome
PROJECT SUMMARY: Most small molecule drugs elicit their effects by modulating protein function, despite the fact that only a small portion of the genome is translated (~1-2%). Furt...
Development of a novel biodegradable inorganic nanoparticle therapeutic for cancer
Abstract Bladder cancer is the sixth most prevalent cancer malignancy.More than 80,000 new cases are diagnosed in the USA each year, among which 75% are non-muscle-invasive bladder...
Transforming Human Pancreatic Cancer Into An Immunologic Disease
Pancreatic ductal adenocarcinoma (PDA) is rising in incidence but remains deadly for most patients.Some progress has occurred in activating immune responses against PDA, however th...
Integration of neo-antigen vaccines and immune checkpoint therapy
Project 1 Summary Immune-checkpoint inhibitors (ICIs) are providing durable clinical responses in about 20% of cancer patients, but have minimal effect in cancers lacking intra-tum...
Mechanisms of immunomodulation with epigenetic therapy
Project Summary/Abstract Immune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) or its ligand have produced unprecedented clinical benefit for some can...
A precision oncology approach to integrating of tumor microenvironment suppressive cell modulators to enhance antitumor immunity
Project Abstract ?Project 3 Pancreatic ductal adenocarcinoma (PDA) is characterized by a dense desmoplastic and immunosuppressive stroma which remains a barrier to even combination...
Integration of stromal targeting agents with immune checkpoint therapy
Pancreatic ductal adenocarcinoma (PDA) is enriched with activated stellate cells and hyaluronic acids (HA) that contribute to the cancer?s poor prognosis.Our recent publication has...
Administrative Core
Administrative Core Summary/Abstract The overall goal of the Administrative Core is to maximize integration of all projects and cores, and collaborations among Program Investigator...
Core B: Clinical Trials and Statistics
Clinical trials and Statistics Core Project Summary The Clinical trials and Statistics Core (Core B) Resource will collaborate and provide comprehensive statistics service and infr...
Core C: Genomics and Bioinformatics
PROJECT SUMMARY The Genomics and Bioinformatics Core (Core C) will provide state-of-the-art sequencing technologies to enable immunogenomic and epigenomic measurements and correspo...
Core D: Digital Pathology and CyTOF
PROJECT SUMMARY The Digital Pathology and Mass Cytometry Core (Core D) will provide state-of-the-art technologies to enable high-parameter single-cell proteomic profiling for all t...
Testing a Clinician and Patient Intervention to Promote smoking Cessation Among Pregnant Women
Perinatal smoking negatively affects the baby and mother as well as healthcare costs; yet, up to one third of women who smoke continue to do so during pregnancy. We tested an SMS t...
Endometrial epithelial stem cells and cancer
Uterine cancer is the 4th most frequent malignancy and the 6th cause of cancer-related deaths in women in the US.While the incidence and mortality rates of some cancers, such as lu...
Leveraging the TCR Repertoire to identify target neoantigens in FLT3-ITD positive Acute Myeloid Leukemia
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for patients with high- risk acute myeloid leukemia (AML).However, HSCT is affecte...
SPHERE (Survivorship Plan Health Record) Implementation Trial
PROJECT SUMMARY/ABSTRACT The Institute of Medicine recommends that each cancer patient receive a survivorship care plan that summarizes information important to the individual?s lo...
Molecular and immunological heterogeneity of Small Cell Lung Cancer (SCLC) and its impact on relapse and therapeutic response
PROJECT SUMMARY Small cell lung cancer (SCLC) is an aggressive malignancy for which there is a critical need for improved therapeutic strategies.While targeted and immune-based the...
An Improved Method of Delivering a Sclerosing Agent for the Treatment of a Malignant Pleural Effusion.
Project Summary / Abstract.We are developing an improved method to treat patients with malignant pleural effusions (MPE), a serious condition that occurs in 175,000 patients in the...
A patient-specific hiPSC model of breast cancer to identify genetic determinants of subclonal response and resistance to PARP inhibitors
PROJECT SUMMARY Breast cancer is the most common cancer among women worldwide, affecting one in eight women in the United States during their lifetime.Existing patient-derived mode...
PAI-1-mediated early-onset endometrial cancer
ABSTRACT PAI-1-mediated early-onset endometrial cancer Over the last 15-years, an increase in obesity-associated endometrial cancer has been observed, coinciding with the globesity...
IncRNA BORG Mediates Alternative Splicing to Enhance Cellular Plasticity in TNBC
Project Summary/Abstract Breast cancer (BC) is the second leading cause of cancer-related deaths among women in the United States.A subset of BC called triple-negative breast cance...