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20,252 grants found
Showing 17,401 – 17,420 of 20,252 grants
Integration of stromal targeting agents with immune checkpoint therapy
Pancreatic ductal adenocarcinoma (PDA) is enriched with activated stellate cells and hyaluronic acids (HA) that contribute to the cancer’s poor prognosis. Our recent publication ha...
Administrative Core
Administrative Core Summary/Abstract The overall goal of the Administrative Core is to maximize integration of all projects and cores, and collaborations among Program Investigator...
Core D: Digital Pathology and CyTOF
PROJECT SUMMARY The Digital Pathology and Mass Cytometry Core (Core D) will provide state-of-the-art technologies to enable high-parameter single-cell proteomic profiling for all t...
Novel Perceptual and Oculomotor Heuristics for Enhancing Radiologic Performance
PROGRAM SUMMARYRadiological imaging is often the first step of the diagnostic pathway for many devastating diseases; thus, an erroneous assessment of “normal” can lead to death. Wh...
Enhancement of ADC selectivity by inverse targeting: Mechanistic studies and optimization
Cancer is a major cause of morbidity and mortality in the US, with 1.8 million cases and 600 thousand cancer deaths projected for 2020. Substantial progress in cancer treatment has...
Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting
ABSTRACT Immune checkpoint inhibitors (ICIs) are a powerful and innovative mode of cancer therapy, believed to be partially responsible for the largest single-year drop in cancer m...
Validation of predictive liquid biomarkers for patients with metastatic prostate cancer
Project Summary/Abstract The University of Wisconsin Carbone Cancer Center (UWCCC), Duke University and Memorial Sloan Kettering Cancer Center (MSKCC) seek support for establishing...
Mechanistic understanding of the lifecycle of a circulating hybrid cell
Metastatic disease accounts for >90% of cancer-related deaths worldwide, yet this phase of tumor progression is the least biologically understood. The consequence of this lack o...
Mechanistic understanding of the lifecycle of a circulating hybrid cell
Metastatic disease accounts for >90% of cancer-related deaths worldwide, yet this phase of tumor progression is the least biologically understood. The consequence of this lack o...
Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohort
ABSTRACT While overall colorectal cancer (CRC) incidence and mortality have declined over the last several decades, CRC incidence and mortality rates continue to be higher in Afric...
Role of IRF2BP2 in Tumor Immune Evasion
PROJECT ABSTRACT Understanding the tumor microenvironment (TME) and the prognostic relevance of the cells contributing to it is vital for developing novel treatments for medullobla...
PAI-1-mediated early-onset endometrial cancer
ABSTRACT PAI-1-mediated early-onset endometrial cancer Over the last 15-years, an increase in obesity-associated endometrial cancer has been observed, coinciding with the globesity...
Development of a novel biodegradable inorganic nanoparticle therapeutic for cancer
Abstract Bladder cancer is the sixth most prevalent cancer malignancy. More than 80,000 new cases are diagnosed in the USA each year, among which 75% are non-muscle-invasive bladde...
Sensitizing Ovarian Cancer To PARP inhibitor and platinum treatment
Abstract Homologous recombination (HR) is an important DNA repair mechanism for DNA damage caused by PARPi and platinum. The HR pathway is closely associated with ovarian cancer de...
Testing a Clinician and Patient Intervention to Promote smoking Cessation Among Pregnant Women
Perinatal smoking negatively affects the baby and mother as well as healthcare costs; yet, up to one third of women who smoke continue to do so during pregnancy. We tested an SMS t...
Malawi Cancer Outcomes Research Program (M-CORP)
PROJECT SUMMARY Globally, there are more deaths from cancer than from HIV, tuberculosis, and malaria combined. In 2018, there were more than 18 million new cancer cases and 9.5 mil...
Leveraging the TCR Repertoire to identify target neoantigens in FLT3-ITD positive Acute Myeloid Leukemia
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for patients with high- risk acute myeloid leukemia (AML). However, HSCT is affect...
B cell antigen receptor (BCR)-driven mechanistic connection between B cell lymphomagenesis and autoimmunity
PROJECT SUMMARY/ABSTRACT Title: B cell antigen receptor (BCR)-driven mechanistic connection between B cell lymphomagenesis and autoimmunity Non-Hodgkin's lymphomas (NHL) are a...
Racial and Socioeconomic Disparities in Breast Cancer Diagnostic Work Up and Outcomes
Project Summary U.S. women of minority race/ethnicity, lower education, lower income, rural residence, and the underinsured experience higher breast cancer disease burden and lower...
Investigating the Metabolic Reprogramming of Ovarian Tumors During Omental Metastasis
ABSTRACT Ovarian cancer (OC) is the most lethal gynecological malignancy, with aggressive metastatic disease responsible for the majority of ovarian cancer related deaths.Despite t...