Browse All Grants
20,252 grants found
Showing 17,381 – 17,400 of 20,252 grants
SPHERE (Survivorship Plan Health Record) Implementation Trial
PROJECT SUMMARY/ABSTRACT The Institute of Medicine recommends that each cancer patient receive a survivorship care plan that summarizes information important to the individual’s lo...
Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohort
ABSTRACT While overall colorectal cancer (CRC) incidence and mortality have declined over the last several decades, CRC incidence and mortality rates continue to be higher in Afric...
OPERATION & SUPPORT OF THE CTEP PROTOCOL AND INFORMATION OFFICE (PIO)
The Protocol Information Office (PIO), Cancer Therapy Evaluation Program (CTEP), Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI) is responsible f...
Administrative Core
Administrative Core Summary/Abstract The overall goal of the Administrative Core is to maximize integration of all projects and cores, and collaborations among Program Investigator...
Core B: Clinical Trials and Statistics
Clinical trials and Statistics Core Project Summary The Clinical trials and Statistics Core (Core B) Resource will collaborate and provide comprehensive statistics service and infr...
Treating colon cancer by regulating intestinal immunity through microbial metabolism
PROJECT SUMMARY Colorectal cancer (CRC) is profoundly affected by the intestinal immune system and the intestinal microbiome, which can exert both pro- and anti-cancer effects that...
Improving Family Cancer History Collection using Social Network, Human Centered Design, and Implementation Science Approaches
PROJECT SUMMARY The research strategy and training plan included in this F99/K00 proposal will enhance the career development and research independence of Caitlin G. Allen, MPH. Th...
HTS for the discovery of activators of NK cell cytotoxicity
Abstract Natural killer (NK) cells are lymphocytes that are capable of killing malignant cells without antigen-specific receptor recognition. Due to this property, NK cells have be...
Modulation of Mcl-1 for Treatment of Lung Cancer
Summary KRAS mutations activate Raf/MEK/ERK1/2 that can directly phosphorylate Mcl-1 at T163, enhancing Mcl-1’s function. KRAS mutations also activate PI3K/AKT that can inactivate...
Control of regulatory T cells by IL-17 in colorectal cancer
Project Summary/Abstract: IL-17 family cytokines promote inflammation that drives the development of colorectal neoplasia, which eventually lead to colorectal cancer (CRC). Thus fa...
Characterizing and Targeting BAX- and BAK-Dependent Cell Death in Cancer
PROJECT SUMMARY The incorporation of Immune checkpoint blockade into anticancer armamentarium has revolutionized cancer therapy in recent years, with FDA approved agents in multipl...
Targeting colorectal cancer stem cells with ALDH1B1 antagonists
Colorectal cancer is the third most common malignancy in the world, with approximately 1.4 million new cases and 700,000 deaths each year. Global incidence rates are expected to es...
Determining the structural- and functional-level effects of diet-specific interventions on the gut microbiota of a diverse sample of Southern United States adults
Racial disparities in colorectal cancer (CRC) incidence persist for blacks and whites. Given the previous work of our team documenting racial differences in the gut microbiota of b...
Understanding the Mechanisms of DC Licensing in CD8 T Cell Priming
ABSTRACTEffective responses to viruses, intracellular pathogens and tumors rely on the successful expansion and arming of cytolytic CD8 T cells from a naïve and quiescent T cell re...
Lentiviral-Induced Swine Model of Spinal Cord Glioma
PROJECT SUMMARY High-grade Spinal Cord Glioma (SCG) is an orphan disease that results in significant morbidity and mortality, with no effective treatment options available. Despite...
Racial and Socioeconomic Disparities in Breast Cancer Diagnostic Work Up and Outcomes
Project Summary U.S. women of minority race/ethnicity, lower education, lower income, rural residence, and the underinsured experience higher breast cancer disease burden and lower...
OPTIMISE: A Shared Care Approach for Improving Comprehensive Care of Cancer Patients with Comorbidities in A Safety-Net System
PROJECT SUMMARY. Cancer survivors have unique healthcare needs including risk for serious late effects, ongoing surveillance, lifestyle modifications to reduce second cancer risk,...
Transforming Human Pancreatic Cancer Into An Immunologic Disease
Pancreatic ductal adenocarcinoma (PDA) is rising in incidence but remains deadly for most patients. Some progress has occurred in activating immune responses against PDA, however t...
Integration of neo-antigen vaccines and immune checkpoint therapy
Project 1 Summary Immune-checkpoint inhibitors (ICIs) are providing durable clinical responses in about 20% of cancer patients, but have minimal effect in cancers lacking intra-tum...
Mechanisms of immunomodulation with epigenetic therapy
Project Summary/Abstract Immune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) or its ligand have produced unprecedented clinical benefit for some can...