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20,252 grants found
Showing 1,721 – 1,740 of 20,252 grants
A SIM2s/SEMA7A Switch Drives ER+ Breast Cancer Progression
SUMMARY Despite the availability of targeted therapies for estrogen receptor positive (ER+) breast cancers, which comprise over 70% of breast cancers, most breast cancer-related de...
Fatty Acid Synthase as a Novel Molecular Target for Colon Cancer Treatment
Altered metabolism is recognized as a common hallmark of cancer. Dysregulation of glucose metabolism has been extensively studied; however, the role of fatty acid (FA) metabolism i...
A Transdisciplinary Approach to Investigating Metabolic Dysregulation in Obese Parent and Child Dyads and Risk of Colorectal Cancer - admin supplement
PROJECT SUMMARY Obesity increases the risk for colorectal cancer (CRC). Indeed, epidemiological studies have found a strong link between a poor diet and colorectal cancer and exper...
Genome Analysis Shared Resource
GENOME ANALYSIS SHARED RESOURCE PROJECT SUMMARY The Genome Analysis Shared Resource (GEN) provides Mayo Clinic Cancer Center (MCCC) members efficient, high-quality, cost-effective...
Bioinformatics Shared Resource
BIOINFORMATICS SHARED RESOURCE PROJECT SUMMARY The mission of the Bioinformatics Shared Resource (BIC) is to provide Mayo Clinic Cancer Center (MCCC) members access to cutting-edge...
Biostatistics Shared Resource
BIOSTATISTICS SHARED RESOURCE PROJECT SUMMARY The Biostatistics Shared Resource (BSR) of the Mayo Clinic Cancer Center (MCCC), under the leadership of Dr. Amylou Dueck, PhD since 2...
Experimental Therapeutics Program
EXPERIMENTAL THERAPEUTICS PROGRAM PROJECT SUMMARY The Experimental Therapeutics (ET) Program contributes to more effective treatment of neoplastic diseases through a spectrum of ba...
Cancer Immunology and Immunotherapy Program
DAVID F. AND MARGARET T. GROHNE FAMILY CANCER IMMUNOLOGY AND IMMUNOTHERAPY PROGRAM PROJECT SUMMARY The Cancer Immunology and Immunotherapy (CII) Program is a longstanding basic and...
Gastrointestinal Cancer Program
GASTROINTESTINAL CANCER PROGRAM PROJECT SUMMARY The Gastrointestinal Cancer (GI) Program of the Mayo Clinic Cancer Center (MCCC) continues to make significant contributions in the...
Hematologic Malignancies Program
HEMATOLOGIC MALIGNANCIES PROGRAM PROJECT SUMMARY The Hematologic Malignancies Program (HMP) is composed of 51 scientists, and clinical investigators from 7 departments at Mayo Clin...
Neuro-Oncology Program
NEURO-ONCOLOGY PROGRAM PROJECT SUMMARY The primary goals of the Mayo Clinic Cancer Center (MCCC) Neuro-Oncology (NONC) Program are to identify underpinning pathogenic mechanisms of...
Cancer Prevention and Control
CANCER PREVENTION AND CONTROL PROGRAM PROJECT SUMMARY The Cancer Prevention and Control (CPC) Program is engaged in defining, evaluating, and implementing novel interventions to re...
Genetic Epidemiology and Risk Assessment Program
GENETIC EPIDEMIOLOGY AND RISK ASSESSMENT PROGRAM PROJECT SUMMARY The unifying goal of the Genetic Epidemiology and Risk Assessment (GERA) Program is the application of genetic and...
Leadership, Planning and Evaluation
LEADERSHIP, PLANNING AND EVALUATION PROJECT SUMMARY The Mayo Clinic Cancer Center (MCCC) has a robust planning and evaluation process in place across all of its sites. Dr. Diasio a...
Project 2
PROJECT SUMMARY – Project 2Underserved breast cancer screening populations, including those that are predominantly composed of racial/ethnic minorities, lower income, lower educate...
Novel proteasome inhibitors targeting both beta5 and beta2 subunits for treatment of triple negative breast cancer
Project Summary/Abstract Proteasome inhibitor (PI) drugs turned untreatable multiple myeloma treatable, significantly improve the quality of life for multiple myeloma patients. The...
A multi-level examination of the influences of racism on cancer pain equity
PROJECT SUMMARY The goal of this proposal is to develop a comprehensive understanding of the scope and key drivers of racial and ethnic disparities in opioid management across the...
Engineered exosome mimetics as targeted biological nanomedicines for pancreatic cancer
Project Summary/Abstract Pancreatic cancer (PC) is one of the most lethal forms of cancer in the United States (5-year survival rate below 10%). PC patients are usually diagnosed w...
Phase I Therapeutic Award: A Novel Engineered Bacterial Anticancer Immunotherapy for Merkel Cell Carcinoma
Tranquility Biodesign is developing an innovative approach for immunomodulating the tumor microenvironment (TME) through engineered bacterial anticancer therapeutics. Merkel Cell C...
PHASE I THERAPEUTIC AWARD: CHIMERIC NANOPARTICLE DELIVERY OF AN SARNA-BASED CANCER VACCINE FOR FAMILIAL ADENOMATOUS POLYPOSIS
Familial Adenomatous Polyposis (FAP) is a rare, inherited disorder typically caused by mutation of the adenomatous polyposis coli (APC) gene, a tumor suppressor gene involved in th...