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20,252 grants found
Showing 17,361 – 17,380 of 20,252 grants
Molecular and cancer-related roles of ACLY exon 14
Project Summary The goal of this proposal is to understand the molecular role of alternative splicing and phosphorylation of ATP- citrate lyase (ACLY) exon 14 and how these events...
SPHERE (Survivorship Plan Health Record) Implementation Trial
PROJECT SUMMARY/ABSTRACT The Institute of Medicine recommends that each cancer patient receive a survivorship care plan that summarizes information important to the individual’s lo...
Role of IRF2BP2 in Tumor Immune Evasion
PROJECT ABSTRACT Understanding the tumor microenvironment (TME) and the prognostic relevance of the cells contributing to it is vital for developing novel treatments for medullobla...
Clinical trial data analysis to design novel treatment regimens in oncology
Project summary Despite the recent development of new treatment modalities in oncology, the overall approval rate for cancer therapeutics is low: only 3% of drugs tested in a phase...
Novel Mechanistic Approaches in Prevention, Treatment and Non-Invasive Assessment of Radiation Cystitis in Mice
ABSTRACT Pelvic organ tumors in men and women are projected to account for 40% and 18%, respectively, of new cancers diagnosed, and 31% and 26%, respectively, of cancer related dea...
Investigation of novel signaling protein in 3D and in vivo PDAC models using second generation Ref-1 inhibitors
PROJECT SUMMARY/ABSTRACT Five-year survival rate of pancreatic ductal adenocarcinoma (PDAC) still remains at a dismal 10%. This poor outcome is attributed to PDAC’s complex tumor m...
Mechanistic understanding of the lifecycle of a circulating hybrid cell
Metastatic disease accounts for >90% of cancer-related deaths worldwide, yet this phase of tumor progression is the least biologically understood. The consequence of this lack o...
Lentiviral-Induced Swine Model of Spinal Cord Glioma
PROJECT SUMMARY High-grade Spinal Cord Glioma (SCG) is an orphan disease that results in significant morbidity and mortality, with no effective treatment options available. Despite...
The Effects of IQOS Use on Cigarette Smoking Behavior
PROJECT SUMMARY Despite increased morbidity and mortality, 34 million adults in the United States smoke combustible cigarettes. Heat-not-burn (HNB) tobacco products are an emerging...
Prostate Cancer Vulnerabilities to BH3 Mimetic Drugs
The anti-apoptotic BCL2 family proteins (including BCL2, BCLXL, and MCL1) act by neutralizing BAX and BAK, and by inhibiting the BH3-only pro-apoptotic proteins that can activate B...
Determining the structural- and functional-level effects of diet-specific interventions on the gut microbiota of a diverse sample of Southern United States adults
Racial disparities in colorectal cancer (CRC) incidence persist for blacks and whites. Given the previous work of our team documenting racial differences in the gut microbiota of b...
Mechanistic understanding of the lifecycle of a circulating hybrid cell.
Project Summary Metastatic disease accounts for >90% of cancer-related deaths worldwide, yet this phase of tumor progression is the least biologically understood. The consequenc...
Ceramide NanoLiposomes as a novel therapeutic for prostate cancer
Project Summary/Abstract Prostate cancer (PCa) is the second most incident cancer in men worldwide and despite vast amounts of research, treatment of this disease remains elusive....
Targeting colorectal cancer stem cells with ALDH1B1 antagonists
Colorectal cancer is the third most common malignancy in the world, with approximately 1.4 million new cases and 700,000 deaths each year. Global incidence rates are expected to es...
Role of a Two-Factor Genetic Circuit Regulating Stemness in Colorectal Cancer
Project Summary Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. Cancer stem cells (CSCs) in the colon are the source of tumor initiation, proliferatio...
Development of a novel biodegradable inorganic nanoparticle therapeutic for cancer
Abstract Bladder cancer is the sixth most prevalent cancer malignancy. More than 80,000 new cases are diagnosed in the USA each year, among which 75% are non-muscle-invasive bladde...
Defining protein synthesis demands and specificities in multiple myeloma
PROJECT SUMMARY Multiple Myeloma (MM) is an incurable cancer of differentiated B lymphocytes (or “plasma cells”) which generally presents late in life and has a median life expecta...
Improving Family Cancer History Collection using Social Network, Human Centered Design, and Implementation Science Approaches
PROJECT SUMMARY The research strategy and training plan included in this F99/K00 proposal will enhance the career development and research independence of Caitlin G. Allen, MPH. Th...
Expanding the Druggable Human Genome
PROJECT SUMMARY: Most small molecule drugs elicit their effects by modulating protein function, despite the fact that only a small portion of the genome is translated (~1-2%). Furt...
Endometrial epithelial stem cells and cancer
Uterine cancer is the 4th most frequent malignancy and the 6th cause of cancer-related deaths in women in the US. While the incidence and mortality rates of some cancers, such as l...