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20,252 grants found
Showing 17,341 – 17,360 of 20,252 grants
Investigation of novel signaling protein in 3D and in vivo PDAC models using second generation Ref-1 inhibitors
PROJECT SUMMARY/ABSTRACT Five-year survival rate of pancreatic ductal adenocarcinoma (PDAC) still remains at a dismal 10%. This poor outcome is attributed to PDAC’s complex tumor m...
Molecular and immunological heterogeneity of Small Cell Lung Cancer (SCLC) and its impact on relapse and therapeutic response
PROJECT SUMMARY Small cell lung cancer (SCLC) is an aggressive malignancy for which there is a critical need for improved therapeutic strategies. While targeted and immune-based th...
PRANAYAMA BASED MOBILE APP FOR BREAST CANCER SURVIVORSHIP: I-CORPS SUPPLEMENT
PROJECT SUMMARY Cancer remains the second leading cause of deaths in the U.S. Encouragingly, recent improvements in early diagnosis and treatment has led to significant increases i...
Sensitizing Ovarian Cancer To PARP inhibitor and platinum treatment
Abstract Homologous recombination (HR) is an important DNA repair mechanism for DNA damage caused by PARPi and platinum. The HR pathway is closely associated with ovarian cancer de...
The Impact of Cigarillo Warnings on Purchasing and Smoking Behaviors Among Young Adult Cigarillo Users
Project Summary Cigarillo use remains a public health concern, particularly among vulnerable populations. Young adults, including those who are Black or African American, have the...
Lipid-based Cancer Therapeutics
Project Summary Significant progress in human cancer therapy in the last decade has been driven by conceptionally new approaches to targeting cancer, including cancer immunotherapy...
Expanding pharmacological modalities for targeted cancer therapy
Project Summary/Abstract Targeted cancer therapy requires complete and sustained pharmacological inhibition of the respective target, which is often challenging to achieve due to t...
The immunosuppressive function of secretory IgM in tumor-bearing mice
Project Summary/Abstract Myeloid-derived suppressor cells (MDSCs) exert potent immunosuppressive functions within tumor microenvironments to promote tumor growth. It is critical to...
Molecular and cancer-related roles of ACLY exon 14
Project Summary The goal of this proposal is to understand the molecular role of alternative splicing and phosphorylation of ATP- citrate lyase (ACLY) exon 14 and how these events...
Bacterial Rogue Methyltransferases Inducing Human Epimutations
PROJECT SUMMARY: DNA methylation is dysregulated in every form of cancer. While there is substantial knowledge regarding the location and function of abnormal DNA methylation acros...
Leveraging the TCR Repertoire to identify target neoantigens in FLT3-ITD positive Acute Myeloid Leukemia
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for patients with high- risk acute myeloid leukemia (AML). However, HSCT is affect...
Treating colon cancer by regulating intestinal immunity through microbial metabolism
PROJECT SUMMARY Colorectal cancer (CRC) is profoundly affected by the intestinal immune system and the intestinal microbiome, which can exert both pro- and anti-cancer effects that...
Elucidating the Role of Epigenetic Plasticity in anti-GD2 Immunotherapy Response
Project Summary (from the funded application) Ganglioside GD2 is expressed on the cell surface of numerous pediatric cancers, including Ewing sarcoma, osteosarcoma, and neuroblasto...
Characterizing and Targeting BAX- and BAK-Dependent Cell Death in Cancer
PROJECT SUMMARY The incorporation of Immune checkpoint blockade into anticancer armamentarium has revolutionized cancer therapy in recent years, with FDA approved agents in multipl...
Endometrial epithelial stem cells and cancer
Uterine cancer is the 4th most frequent malignancy and the 6th cause of cancer-related deaths in women in the US. While the incidence and mortality rates of some cancers, such as l...
Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities
ABSTRACT Compared to non-Hispanic whites, African Americans have a more than 2-fold higher incidence of multiple myeloma (MM) and its asymptomatic precursor condition, monoclonal g...
Analysis and Therapeutic Targeting of the Linear-Ubiquitination Pathway in Hodgkin Lymphoma
PROJECT SUMMARY Hodgkin lymphoma (HL) is the most common (6,000 to 7,000 new cases per year) lymphoma subtype in young adulthood. Although there has been great progress during the...
Novel Perceptual and Oculomotor Heuristics for Enhancing Radiologic Performance
PROGRAM SUMMARYRadiological imaging is often the first step of the diagnostic pathway for many devastating diseases; thus, an erroneous assessment of “normal” can lead to death. Wh...
Enhancement of ADC selectivity by inverse targeting: Mechanistic studies and optimization
Cancer is a major cause of morbidity and mortality in the US, with 1.8 million cases and 600 thousand cancer deaths projected for 2020. Substantial progress in cancer treatment has...
Investigating the biology and therapeutic vulnerabilities of ER+ metastatic breast cancer with activating HER2 mutations
Project Summary/Abstract The candidate, Ms. Utthara Nayar, PhD, is a translational cancer biologist, and currently a Research Fellow in Medicine at Dana-Farber Cancer Institute, Ha...