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20,252 grants found
Showing 17,321 – 17,340 of 20,252 grants
Direct therapeutic intervention of the tumor microenvironment with a potent inhibitor of fibronectin assembly
PROJECT SUMMARY Among the hallmarks of cancer, the extracellular matrix contributes to the regulation of each of the hallmark principles underlying tumor progression. Importantly,...
Leveraging the TCR Repertoire to identify target neoantigens in FLT3-ITD positive Acute Myeloid Leukemia
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for patients with high- risk acute myeloid leukemia (AML). However, HSCT is affect...
PAI-1-mediated early-onset endometrial cancer
ABSTRACT PAI-1-mediated early-onset endometrial cancer Over the last 15-years, an increase in obesity-associated endometrial cancer has been observed, coinciding with the globesity...
Role of IRF2BP2 in Tumor Immune Evasion
PROJECT ABSTRACT Understanding the tumor microenvironment (TME) and the prognostic relevance of the cells contributing to it is vital for developing novel treatments for medullobla...
Treating colon cancer by regulating intestinal immunity through microbial metabolism
PROJECT SUMMARY Colorectal cancer (CRC) is profoundly affected by the intestinal immune system and the intestinal microbiome, which can exert both pro- and anti-cancer effects that...
Elucidating the role of the SWI/SNF complex in mediating hormone therapy resistance in breast cancer
PROJECT SUMMARY Approximately 70% of breast cancers express estrogen receptor (ER) and are treated typically with endocrine therapy. Despite the clinical benefit obtained from seve...
Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities
ABSTRACT Compared to non-Hispanic whites, African Americans have a more than 2-fold higher incidence of multiple myeloma (MM) and its asymptomatic precursor condition, monoclonal g...
Understanding the Mechanisms of DC Licensing in CD8 T Cell Priming
ABSTRACTEffective responses to viruses, intracellular pathogens and tumors rely on the successful expansion and arming of cytolytic CD8 T cells from a naïve and quiescent T cell re...
Novel Perceptual and Oculomotor Heuristics for Enhancing Radiologic Performance
PROGRAM SUMMARYRadiological imaging is often the first step of the diagnostic pathway for many devastating diseases; thus, an erroneous assessment of “normal” can lead to death. Wh...
Novel Strategies to Treat Diffuse Midline Glioma with CAR T Cell Therapy
PROJECT SUMMARY Although chimeric antigen receptor (CAR) T cells have been remarkably successful in the hematologic setting, identification of truly tumor specific antigens for man...
Mechanistic understanding of the lifecycle of a circulating hybrid cell
Metastatic disease accounts for >90% of cancer-related deaths worldwide, yet this phase of tumor progression is the least biologically understood. The consequence of this lack o...
Investigating the biology and therapeutic vulnerabilities of ER+ metastatic breast cancer with activating HER2 mutations
Project Summary/Abstract The candidate, Ms. Utthara Nayar, PhD, is a translational cancer biologist, and currently a Research Fellow in Medicine at Dana-Farber Cancer Institute, Ha...
Testing a Clinician and Patient Intervention to Promote smoking Cessation Among Pregnant Women
Perinatal smoking negatively affects the baby and mother as well as healthcare costs; yet, up to one third of women who smoke continue to do so during pregnancy. We tested an SMS t...
The Effects of IQOS Use on Cigarette Smoking Behavior
PROJECT SUMMARY Despite increased morbidity and mortality, 34 million adults in the United States smoke combustible cigarettes. Heat-not-burn (HNB) tobacco products are an emerging...
Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohort
ABSTRACT While overall colorectal cancer (CRC) incidence and mortality have declined over the last several decades, CRC incidence and mortality rates continue to be higher in Afric...
Hyperthermic Intraperitoneal Chemotherapy Mechanisms in Epithelial Ovarian Cancer
Project Summary Epithelial ovarian cancer (EOC) is a leading cause of gynecologic cancer death in women, highlighting the critical clinical need for new therapeutic strategies. In...
Ceramide NanoLiposomes as a novel therapeutic for prostate cancer
Project Summary/Abstract Prostate cancer (PCa) is the second most incident cancer in men worldwide and despite vast amounts of research, treatment of this disease remains elusive....
Endometrial epithelial stem cells and cancer
Uterine cancer is the 4th most frequent malignancy and the 6th cause of cancer-related deaths in women in the US. While the incidence and mortality rates of some cancers, such as l...
Control of regulatory T cells by IL-17 in colorectal cancer
Project Summary/Abstract: IL-17 family cytokines promote inflammation that drives the development of colorectal neoplasia, which eventually lead to colorectal cancer (CRC). Thus fa...
A multitargeted nanocarrier inhibitor of undruggable transcription factors for treating castration resistant prostate cancer
Project Summary This project addresses the critical need for treatments of castration resistant prostate cancer (CRPC) by proposing to engineer and develop a novel, nanostructured...