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20,252 grants found
Showing 17,301 – 17,320 of 20,252 grants
The immunosuppressive function of secretory IgM in tumor-bearing mice
Project Summary/Abstract Myeloid-derived suppressor cells (MDSCs) exert potent immunosuppressive functions within tumor microenvironments to promote tumor growth. It is critical to...
Administrative Core
SUMMARY ADMINISTRATIVE COMPONENT The Administrative Core comprises a team of faculty and staff who will work together to oversee the research, training, planning, and outreach acti...
OPERATION & SUPPORT OF THE CTEP PROTOCOL AND INFORMATION OFFICE (PIO)
The Protocol Information Office (PIO), Cancer Therapy Evaluation Program (CTEP), Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI) is responsible f...
B cell antigen receptor (BCR)-driven mechanistic connection between B cell lymphomagenesis and autoimmunity
PROJECT SUMMARY/ABSTRACT Title: B cell antigen receptor (BCR)-driven mechanistic connection between B cell lymphomagenesis and autoimmunity Non-Hodgkin's lymphomas (NHL) are a...
Improving Family Cancer History Collection using Social Network, Human Centered Design, and Implementation Science Approaches
PROJECT SUMMARY The research strategy and training plan included in this F99/K00 proposal will enhance the career development and research independence of Caitlin G. Allen, MPH. Th...
Role of a Two-Factor Genetic Circuit Regulating Stemness in Colorectal Cancer
Project Summary Colorectal cancer (CRC) is the third leading cause of cancer death worldwide. Cancer stem cells (CSCs) in the colon are the source of tumor initiation, proliferatio...
The Interplay Between PD-1 Blockade and T cell Development in the Context of Thymic Regeneration in Prostate Cancer
PROJECT SUMMARY Immunotherapies, such as PD-1 blockade, have shown therapeutic potential in prostate cancer; however, only a portion of patients respond, suggesting unidentified me...
Development of a novel biodegradable inorganic nanoparticle therapeutic for cancer
Abstract Bladder cancer is the sixth most prevalent cancer malignancy. More than 80,000 new cases are diagnosed in the USA each year, among which 75% are non-muscle-invasive bladde...
Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting
ABSTRACT Immune checkpoint inhibitors (ICIs) are a powerful and innovative mode of cancer therapy, believed to be partially responsible for the largest single-year drop in cancer m...
Racial and Socioeconomic Disparities in Breast Cancer Diagnostic Work Up and Outcomes
Project Summary U.S. women of minority race/ethnicity, lower education, lower income, rural residence, and the underinsured experience higher breast cancer disease burden and lower...
Novel Mechanistic Approaches in Prevention, Treatment and Non-Invasive Assessment of Radiation Cystitis in Mice
ABSTRACT Pelvic organ tumors in men and women are projected to account for 40% and 18%, respectively, of new cancers diagnosed, and 31% and 26%, respectively, of cancer related dea...
Integration of neo-antigen vaccines and immune checkpoint therapy
Project 1 Summary Immune-checkpoint inhibitors (ICIs) are providing durable clinical responses in about 20% of cancer patients, but have minimal effect in cancers lacking intra-tum...
Mechanisms of immunomodulation with epigenetic therapy
Project Summary/Abstract Immune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) or its ligand have produced unprecedented clinical benefit for some can...
A precision oncology approach to integrating of tumor microenvironment suppressive cell modulators to enhance antitumor immunity
Project Abstract – Project 3 Pancreatic ductal adenocarcinoma (PDA) is characterized by a dense desmoplastic and immunosuppressive stroma which remains a barrier to even combinatio...
Integration of stromal targeting agents with immune checkpoint therapy
Pancreatic ductal adenocarcinoma (PDA) is enriched with activated stellate cells and hyaluronic acids (HA) that contribute to the cancer’s poor prognosis. Our recent publication ha...
Administrative Core
Administrative Core Summary/Abstract The overall goal of the Administrative Core is to maximize integration of all projects and cores, and collaborations among Program Investigator...
Core B: Clinical Trials and Statistics
Clinical trials and Statistics Core Project Summary The Clinical trials and Statistics Core (Core B) Resource will collaborate and provide comprehensive statistics service and infr...
Core C: Genomics and Bioinformatics
PROJECT SUMMARY The Genomics and Bioinformatics Core (Core C) will provide state-of-the-art sequencing technologies to enable immunogenomic and epigenomic measurements and correspo...
Core D: Digital Pathology and CyTOF
PROJECT SUMMARY The Digital Pathology and Mass Cytometry Core (Core D) will provide state-of-the-art technologies to enable high-parameter single-cell proteomic profiling for all t...
Self-assembled iron(III) hosts for MRI-guided delivery of chemotherapeutics
Abstract Image-guided drug delivery is a promising approach to improve tumor uptake and to prevent the accumulation of toxic chemotherapeutic agents in healthy tissue. The imaging...