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20,252 grants found
Showing 17,281 – 17,300 of 20,252 grants
Novel Mechanistic Approaches in Prevention, Treatment and Non-Invasive Assessment of Radiation Cystitis in Mice
ABSTRACT Pelvic organ tumors in men and women are projected to account for 40% and 18%, respectively, of new cancers diagnosed, and 31% and 26%, respectively, of cancer related dea...
Targeting colorectal cancer stem cells with ALDH1B1 antagonists
Colorectal cancer is the third most common malignancy in the world, with approximately 1.4 million new cases and 700,000 deaths each year.Global incidence rates are expected to esc...
Self-assembled iron(III) hosts for MRI-guided delivery of chemotherapeutics
Abstract Image-guided drug delivery is a promising approach to improve tumor uptake and to prevent the accumulation of toxic chemotherapeutic agents in healthy tissue. The imaging...
Sensitizing Ovarian Cancer To PARP inhibitor and platinum treatment
Abstract Homologous recombination (HR) is an important DNA repair mechanism for DNA damage caused by PARPi and platinum. The HR pathway is closely associated with ovarian cancer de...
Enhancement of ADC selectivity by inverse targeting: Mechanistic studies and optimization
Cancer is a major cause of morbidity and mortality in the US, with 1.8 million cases and 600 thousand cancer deaths projected for 2020.Substantial progress in cancer treatment has...
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
SUMMARY ABSTRACT Single cell RNA profiling and DNA sequencing has revolutionized our understanding of the tumor microenvironment (TME) but such data lacks the spatial context and m...
Mechanistic understanding of the lifecycle of a circulating hybrid cell
Metastatic disease accounts for >90% of cancer-related deaths worldwide, yet this phase of tumor progression is the least biologically understood.The consequence of this lack of...
B cell antigen receptor (BCR)-driven mechanistic connection between B cell lymphomagenesis and autoimmunity
PROJECT SUMMARY/ABSTRACT Title: B cell antigen receptor (BCR)-driven mechanistic connection between B cell lymphomagenesis and autoimmunity Non-Hodgkin's lymphomas (NHL) are a...
Lipid-based Cancer Therapeutics
Project Summary Significant progress in human cancer therapy in the last decade has been driven by conceptionally new approaches to targeting cancer, including cancer immunotherapy...
Determining the structural- and functional-level effects of diet-specific interventions on the gut microbiota of a diverse sample of Southern United States adults
Racial disparities in colorectal cancer (CRC) incidence persist for blacks and whites.Given the previous work of our team documenting racial differences in the gut microbiota of bl...
Integrators of Metastatic Potential
Metastases cause major morbidities and nearly all of deaths in patients with breast cancer and other solid tumors.Our preliminary studies point to an intracellular signaling molecu...
Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicines
ABSTRACT Despite the progress in molecular therapy and immunotherapy, multiple underlying cellular mechanisms cause resistance to cancer therapy. There are urgent needs to develop...
Obesity, Metabolism and Breast Cancer Metastasis
Obesity, metabolic reprogramming, and breast cancer metastasis: Role of extracellular vesicles Abstract Obesity increases the risk of triple-negative breast cancer(TNBC) and its pr...
Psychosocial Risk in Young Survivors of Early Onset Pediatric Cancer: The Moderating Role of Residential Location (Diversity Supplement for V. Patterson)
Despite increased survival,1 over two-thirds of children with cancer experience late effects, such as secondary cancers, sensorimotor deficits, and neurocognitive impairment.2,3 Ps...
Ceramide NanoLiposomes as a novel therapeutic for prostate cancer
Project Summary/Abstract Prostate cancer (PCa) is the second most incident cancer in men worldwide and despite vast amounts of research, treatment of this disease remains elusive.T...
Patient-Centered Decision-Making for Management of Small Renal Tumors - Supplement
Project Summary The current treatment paradigm for small kidney tumors (? 4 cm) has resulted in worsened overall survival despite earlier detection and aggressive treatment with su...
SPHERE (Survivorship Plan Health Record) Implementation Trial
PROJECT SUMMARY/ABSTRACT The Institute of Medicine recommends that each cancer patient receive a survivorship care plan that summarizes information important to the individual’s lo...
A System for Xerostomia Risk Classification after Head & Neck Cancer Radiotherapy
Project Summary/Abstract Head and neck cancer (HNC) patients survive years after oncologic therapy due to increased efficacy of therapy, increased incidences of human papilloma vir...
Targeting colorectal cancer stem cells with ALDH1B1 antagonists
Colorectal cancer is the third most common malignancy in the world, with approximately 1.4 million new cases and 700,000 deaths each year. Global incidence rates are expected to es...
Elucidating the Role of Epigenetic Plasticity in anti-GD2 Immunotherapy Response
Project Summary Ganglioside GD2 is expressed on the cell surface of numerous pediatric cancers, including Ewing sarcoma, osteosarcoma, and neuroblastoma. In 2015, FDA approval of t...