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20,252 grants found
Showing 17,261 – 17,280 of 20,252 grants
Investigating the impact of heterogeneous and homogenous neoantigen expression patterns on the anti-tumor immune response
PROJECT SUMMARY/ABSTRACT Immunotherapies like checkpoint blockade therapy (CBT) have been a breakthrough for cancer treatment with durable responses observed in patients with advan...
Supplement - PRANAYAMA BASED GROUP VIDEO APP FOR CANCER SURVIVORSHIP. Phase I. Breast Cancer Pilot
PROJECT SUMMARY Cancer remains the second leading cause of deaths in the U.S.Encouragingly, recent improvements in early diagnosis and treatment has led to significant increases in...
Defining protein synthesis demands and specificities in multiple myeloma
PROJECT SUMMARY Multiple Myeloma (MM) is an incurable cancer of differentiated B lymphocytes (or “plasma cells”) which generally presents late in life and has a median life expecta...
Determining the structural- and functional-level effects of diet-specific interventions on the gut microbiota of a diverse sample of Southern United States adults
Racial disparities in colorectal cancer (CRC) incidence persist for blacks and whites. Given the previous work of our team documenting racial differences in the gut microbiota of b...
Prostate Cancer Vulnerabilities to BH3 Mimetic Drugs
The anti-apoptotic BCL2 family proteins (including BCL2, BCLXL, and MCL1) act by neutralizing BAX and BAK, and by inhibiting the BH3-only pro-apoptotic proteins that can activate B...
Targeted Chemical-Genetic Screen Platform for Identifying Novel AML Therapeutics
PROJECT ABSTRACT Over 93% of cancer patients do not receive therapeutic benefit from oncology precision medicine. This can be partly attributed to 1) not understanding the genetic...
Investigating the Metabolic Reprogramming of Ovarian Tumors During Omental Metastasis
ABSTRACT Ovarian cancer (OC) is the most lethal gynecological malignancy, with aggressive metastatic disease responsible for the majority of ovarian cancer related deaths. Despite...
Quantitative Lung Function Imaging to Reduce Toxicity for patients treated with Radiation and Immunotherapy
The proposed project is in the field of thoracic oncology. Lung cancer patients that get treated with radiotherapy and immunotherapy are at risk of developing serious lung side-eff...
A patient-specific hiPSC model of breast cancer to identify genetic determinants of subclonal response and resistance to PARP inhibitors
PROJECT SUMMARY Breast cancer is the most common cancer among women worldwide, affecting one in eight women in the United States during their lifetime. Existing patient-derived mod...
OPERATION & SUPPORT OF THE CTEP PROTOCOL AND INFORMATION OFFICE (PIO)
The Protocol Information Office (PIO), Cancer Therapy Evaluation Program (CTEP), Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI) is responsible f...
PAI-1-mediated early-onset endometrial cancer
ABSTRACT PAI-1-mediated early-onset endometrial cancer Over the last 15-years, an increase in obesity-associated endometrial cancer has been observed, coinciding with the globesity...
Sensitizing Ovarian Cancer To PARP inhibitor and platinum treatment
Abstract Homologous recombination (HR) is an important DNA repair mechanism for DNA damage caused by PARPi and platinum. The HR pathway is closely associated with ovarian cancer de...
Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohort
ABSTRACT While overall colorectal cancer (CRC) incidence and mortality have declined over the last several decades, CRC incidence and mortality rates continue to be higher in Afric...
Targeted Chemical-Genetic Screen Platform for Identifying Novel AML Therapeutics
PROJECT ABSTRACT Over 93% of cancer patients do not receive therapeutic benefit from oncology precision medicine. This can be partly attributed to 1) not understanding the genetic...
Elucidating the role of gut, blood, and tumor microbiota in brain metastasis
Project Summary Brain metastasis is a substantial clinical challenge associated with rising incidence and significant morbidity and mortality. Understanding the mechanisms underlyi...
The Impact of Cigarillo Warnings on Purchasing and Smoking Behaviors Among Young Adult Cigarillo Users
Project Summary Cigarillo use remains a public health concern, particularly among vulnerable populations. Young adults, including those who are Black or African American, have the...
Investigating the impact of heterogeneous and homogenous neoantigen expression patterns on the anti-tumor immune response
PROJECT SUMMARY/ABSTRACT Immunotherapies like checkpoint blockade therapy (CBT) have been a breakthrough for cancer treatment with durable responses observed in patients with advan...
Control of regulatory T cells by IL-17 in colorectal cancer
Project Summary/Abstract: IL-17 family cytokines promote inflammation that drives the development of colorectal neoplasia, which eventually lead to colorectal cancer (CRC). Thus fa...
Core D: Digital Pathology and CyTOF
PROJECT SUMMARY The Digital Pathology and Mass Cytometry Core (Core D) will provide state-of-the-art technologies to enable high-parameter single-cell proteomic profiling for all t...
Ceramide NanoLiposomes as a novel therapeutic for prostate cancer
Project Summary/Abstract Prostate cancer (PCa) is the second most incident cancer in men worldwide and despite vast amounts of research, treatment of this disease remains elusive....