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20,252 grants found
Showing 17,241 – 17,260 of 20,252 grants
A multitargeted nanocarrier inhibitor of undruggable transcription factors for treating castration resistant prostate cancer
Project Summary This project addresses the critical need for treatments of castration resistant prostate cancer (CRPC) by proposing to engineer and develop a novel, nanostructured...
Control of regulatory T cells by IL-17 in colorectal cancer
Project Summary/Abstract: IL-17 family cytokines promote inflammation that drives the development of colorectal neoplasia, which eventually lead to colorectal cancer (CRC). Thus fa...
Prostate Cancer Vulnerabilities to BH3 Mimetic Drugs
The anti-apoptotic BCL2 family proteins (including BCL2, BCLXL, and MCL1) act by neutralizing BAX and BAK, and by inhibiting the BH3-only pro-apoptotic proteins that can activate B...
Novel Strategies to Treat Diffuse Midline Glioma with CAR T Cell Therapy
PROJECT SUMMARY Although chimeric antigen receptor (CAR) T cells have been remarkably successful in the hematologic setting, identification of truly tumor specific antigens for man...
Hyperthermic Intraperitoneal Chemotherapy Mechanisms in Epithelial Ovarian Cancer
Project Summary Epithelial ovarian cancer (EOC) is a leading cause of gynecologic cancer death in women, highlighting the critical clinical need for new therapeutic strategies.In 2...
Modulating extracellular TCR-CD3 interactions to identify new melanoma immunotherapy targets
ABSTRACT Melanoma is one of the deadliest and aggressive form of skin cancer.Main treatment options in metastatic melanoma involve T cell immunotherapy using checkpoint blockade (a...
Investigation of novel signaling protein in 3D and in vivo PDAC models using second generation Ref-1 inhibitors
PROJECT SUMMARY/ABSTRACT Five-year survival rate of pancreatic ductal adenocarcinoma (PDAC) still remains at a dismal 10%.This poor outcome is attributed to PDAC?s complex tumor mi...
Modulation of Mcl-1 for Treatment of Lung Cancer
Summary KRAS mutations activate Raf/MEK/ERK1/2 that can directly phosphorylate Mcl-1 at T163, enhancing Mcl-1?s function.KRAS mutations also activate PI3K/AKT that can inactivate G...
OPTIMISE: A Shared Care Approach for Improving Comprehensive Care of Cancer Patients with Comorbidities in A Safety-Net System
PROJECT SUMMARY.Cancer survivors have unique healthcare needs including risk for serious late effects, ongoing surveillance, lifestyle modifications to reduce second cancer risk, a...
The Impact of Cigarillo Warnings on Purchasing and Smoking Behaviors Among Young Adult Cigarillo Users
Project Summary Cigarillo use remains a public health concern, particularly among vulnerable populations. Young adults, including those who are Black or African American, have the...
Novel Perceptual and Oculomotor Heuristics for Enhancing Radiologic Performance
PROGRAM SUMMARY Radiological imaging is often the first step of the diagnostic pathway for many devastating diseases; thus, an erroneous assessment of ?normal? can lead to death.Wh...
Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting
ABSTRACT Immune checkpoint inhibitors (ICIs) are a powerful and innovative mode of cancer therapy, believed to be partially responsible for the largest single-year drop in cancer m...
Role of a Two-Factor Genetic Circuit Regulating Stemness in Colorectal Cancer
Project Summary Colorectal cancer (CRC) is the third leading cause of cancer death worldwide.Cancer stem cells (CSCs) in the colon are the source of tumor initiation, proliferation...
Molecular and cancer-related roles of ACLY exon 14
Project Summary The goal of this proposal is to understand the molecular role of alternative splicing and phosphorylation of ATP- citrate lyase (ACLY) exon 14 and how these events...
Lentiviral-Induced Swine Model of Spinal Cord Glioma
PROJECT SUMMARY High-grade Spinal Cord Glioma (SCG) is an orphan disease that results in significant morbidity and mortality, with no effective treatment options available.Despite...
The Interplay Between PD-1 Blockade and T cell Development in the Context of Thymic Regeneration in Prostate Cancer
PROJECT SUMMARY Immunotherapies, such as PD-1 blockade, have shown therapeutic potential in prostate cancer; however, only a portion of patients respond, suggesting unidentified me...
Defining protein synthesis demands and specificities in multiple myeloma
PROJECT SUMMARY Multiple Myeloma (MM) is an incurable cancer of differentiated B lymphocytes (or ?plasma cells?) which generally presents late in life and has a median life expecta...
Elucidating the Role of Epigenetic Plasticity in anti-GD2 Immunotherapy Response
Project Summary Ganglioside GD2 is expressed on the cell surface of numerous pediatric cancers, including Ewing sarcoma, osteosarcoma, and neuroblastoma.In 2015, FDA approval of th...
Novel Mechanistic Approaches in Prevention, Treatment and Non-Invasive Assessment of Radiation Cystitis in Mice
ABSTRACT Pelvic organ tumors in men and women are projected to account for 40% and 18%, respectively, of new cancers diagnosed, and 31% and 26%, respectively, of cancer related dea...
Analysis and Therapeutic Targeting of the Linear-Ubiquitination Pathway in Hodgkin Lymphoma
PROJECT SUMMARY Hodgkin lymphoma (HL) is the most common (6,000 to 7,000 new cases per year) lymphoma subtype in young adulthood.Although there has been great progress during the l...