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20,252 grants found
Showing 17,201 – 17,220 of 20,252 grants
Transforming Human Pancreatic Cancer Into An Immunologic Disease
Pancreatic ductal adenocarcinoma (PDA) is rising in incidence but remains deadly for most patients. Some progress has occurred in activating immune responses against PDA, however t...
Integration of neo-antigen vaccines and immune checkpoint therapy
Project 1 Summary Immune-checkpoint inhibitors (ICIs) are providing durable clinical responses in about 20% of cancer patients, but have minimal effect in cancers lacking intra-tum...
Mechanisms of immunomodulation with epigenetic therapy
Project Summary/Abstract Immune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) or its ligand have produced unprecedented clinical benefit for some can...
A precision oncology approach to integrating of tumor microenvironment suppressive cell modulators to enhance antitumor immunity
Project Abstract – Project 3 Pancreatic ductal adenocarcinoma (PDA) is characterized by a dense desmoplastic and immunosuppressive stroma which remains a barrier to even combinatio...
Integration of stromal targeting agents with immune checkpoint therapy
Pancreatic ductal adenocarcinoma (PDA) is enriched with activated stellate cells and hyaluronic acids (HA) that contribute to the cancer’s poor prognosis. Our recent publication ha...
Core C: Genomics and Bioinformatics
PROJECT SUMMARY The Genomics and Bioinformatics Core (Core C) will provide state-of-the-art sequencing technologies to enable immunogenomic and epigenomic measurements and correspo...
Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting
ABSTRACT Immune checkpoint inhibitors (ICIs) are a powerful and innovative mode of cancer therapy, believed to be partially responsible for the largest single-year drop in cancer m...
Quantitative Lung Function Imaging to Reduce Toxicity for patients treated with Radiation and Immunotherapy
The proposed project is in the field of thoracic oncology. Lung cancer patients that get treated with radiotherapy and immunotherapy are at risk of developing serious lung side-eff...
Expanding the Druggable Human Genome
PROJECT SUMMARY: Most small molecule drugs elicit their effects by modulating protein function, despite the fact that only a small portion of the genome is translated (~1-2%). Furt...
Prostate Cancer Vulnerabilities to BH3 Mimetic Drugs
The anti-apoptotic BCL2 family proteins (including BCL2, BCLXL, and MCL1) act by neutralizing BAX and BAK, and by inhibiting the BH3-only pro-apoptotic proteins that can activate B...
Analysis and Therapeutic Targeting of the Linear-Ubiquitination Pathway in Hodgkin Lymphoma
PROJECT SUMMARY Hodgkin lymphoma (HL) is the most common (6,000 to 7,000 new cases per year) lymphoma subtype in young adulthood. Although there has been great progress during the...
Molecular and immunological heterogeneity of Small Cell Lung Cancer (SCLC) and its impact on relapse and therapeutic response
PROJECT SUMMARY Small cell lung cancer (SCLC) is an aggressive malignancy for which there is a critical need for improved therapeutic strategies. While targeted and immune-based th...
A precision oncology approach to integrating of tumor microenvironment suppressive cell modulators to enhance antitumor immunity
Project Abstract – Project 3 Pancreatic ductal adenocarcinoma (PDA) is characterized by a dense desmoplastic and immunosuppressive stroma which remains a barrier to even combinatio...
Core B: Clinical Trials and Statistics
Clinical trials and Statistics Core Project Summary The Clinical trials and Statistics Core (Core B) Resource will collaborate and provide comprehensive statistics service and infr...
Core C: Genomics and Bioinformatics
PROJECT SUMMARY The Genomics and Bioinformatics Core (Core C) will provide state-of-the-art sequencing technologies to enable immunogenomic and epigenomic measurements and correspo...
Molecular and cancer-related roles of ACLY exon 14
Project Summary The goal of this proposal is to understand the molecular role of alternative splicing and phosphorylation of ATP- citrate lyase (ACLY) exon 14 and how these events...
Quantitative Lung Function Imaging to Reduce Toxicity for patients treated with Radiation and Immunotherapy
The proposed project is in the field of thoracic oncology. Lung cancer patients that get treated with radiotherapy and immunotherapy are at risk of developing serious lung side-eff...
Investigation of novel signaling protein in 3D and in vivo PDAC models using second generation Ref-1 inhibitors
PROJECT SUMMARY/ABSTRACT Five-year survival rate of pancreatic ductal adenocarcinoma (PDAC) still remains at a dismal 10%. This poor outcome is attributed to PDAC’s complex tumor m...
OPTIMISE: A Shared Care Approach for Improving Comprehensive Care of Cancer Patients with Comorbidities in A Safety-Net System
PROJECT SUMMARY. Cancer survivors have unique healthcare needs including risk for serious late effects, ongoing surveillance, lifestyle modifications to reduce second cancer risk,...
Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities
ABSTRACT Compared to non-Hispanic whites, African Americans have a more than 2-fold higher incidence of multiple myeloma (MM) and its asymptomatic precursor condition, monoclonal g...