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20,252 grants found
Showing 17,181 – 17,200 of 20,252 grants
Expanding the Druggable Human Genome
PROJECT SUMMARY: Most small molecule drugs elicit their effects by modulating protein function, despite the fact that only a small portion of the genome is translated (~1-2%). Furt...
Transforming Human Pancreatic Cancer Into An Immunologic Disease
Pancreatic ductal adenocarcinoma (PDA) is rising in incidence but remains deadly for most patients. Some progress has occurred in activating immune responses against PDA, however t...
OPTIMISE: A Shared Care Approach for Improving Comprehensive Care of Cancer Patients with Comorbidities in A Safety-Net System
PROJECT SUMMARY. Cancer survivors have unique healthcare needs including risk for serious late effects, ongoing surveillance, lifestyle modifications to reduce second cancer risk,...
The Impact of Cigarillo Warnings on Purchasing and Smoking Behaviors Among Young Adult Cigarillo Users
Project Summary Cigarillo use remains a public health concern, particularly among vulnerable populations. Young adults, including those who are Black or African American, have the...
Validation of predictive liquid biomarkers for patients with metastatic prostate cancer
Project Summary/Abstract The University of Wisconsin Carbone Cancer Center (UWCCC), Duke University and Memorial Sloan Kettering Cancer Center (MSKCC) seek support for establishing...
Modulation of Mcl-1 for Treatment of Lung Cancer
Summary KRAS mutations activate Raf/MEK/ERK1/2 that can directly phosphorylate Mcl-1 at T163, enhancing Mcl-1’s function. KRAS mutations also activate PI3K/AKT that can inactivate...
Enhancement of ADC selectivity by inverse targeting: Mechanistic studies and optimization
Cancer is a major cause of morbidity and mortality in the US, with 1.8 million cases and 600 thousand cancer deaths projected for 2020. Substantial progress in cancer treatment has...
Modulation of Mcl-1 for Treatment of Lung Cancer
Summary KRAS mutations activate Raf/MEK/ERK1/2 that can directly phosphorylate Mcl-1 at T163, enhancing Mcl-1’s function. KRAS mutations also activate PI3K/AKT that can inactivate...
Malawi Cancer Outcomes Research Program (M-CORP)
PROJECT SUMMARY Globally, there are more deaths from cancer than from HIV, tuberculosis, and malaria combined. In 2018, there were more than 18 million new cancer cases and 9.5 mil...
Understanding the Mechanisms of DC Licensing in CD8 T Cell Priming
ABSTRACTEffective responses to viruses, intracellular pathogens and tumors rely on the successful expansion and arming of cytolytic CD8 T cells from a naïve and quiescent T cell re...
HTS for the discovery of activators of NK cell cytotoxicity
Abstract Natural killer (NK) cells are lymphocytes that are capable of killing malignant cells without antigen-specific receptor recognition. Due to this property, NK cells have be...
A patient-specific hiPSC model of breast cancer to identify genetic determinants of subclonal response and resistance to PARP inhibitors
PROJECT SUMMARY Breast cancer is the most common cancer among women worldwide, affecting one in eight women in the United States during their lifetime. Existing patient-derived mod...
OPTIMISE: A Shared Care Approach for Improving Comprehensive Care of Cancer Patients with Comorbidities in A Safety-Net System
PROJECT SUMMARY. Cancer survivors have unique healthcare needs including risk for serious late effects, ongoing surveillance, lifestyle modifications to reduce second cancer risk,...
Testing a Clinician and Patient Intervention to Promote smoking Cessation Among Pregnant Women
Perinatal smoking negatively affects the baby and mother as well as healthcare costs; yet, up to one third of women who smoke continue to do so during pregnancy. We tested an SMS t...
Molecular and immunological heterogeneity of Small Cell Lung Cancer (SCLC) and its impact on relapse and therapeutic response
PROJECT SUMMARY Small cell lung cancer (SCLC) is an aggressive malignancy for which there is a critical need for improved therapeutic strategies. While targeted and immune-based th...
B cell antigen receptor (BCR)-driven mechanistic connection between B cell lymphomagenesis and autoimmunity
PROJECT SUMMARY/ABSTRACT Title: B cell antigen receptor (BCR)-driven mechanistic connection between B cell lymphomagenesis and autoimmunity Non-Hodgkin's lymphomas (NHL) are a...
Supplement: Effects of Comorbidity Management and Complex Care Coordination on Cancer Caregivers
PROJECT SUMMARY. The overarching goal of this Diversity Supplement is to prepare and launch Dr. Maria Lizette Rangel into an academic career as an independent scientist. Dr. Rangel...
Racial and Socioeconomic Disparities in Breast Cancer Diagnostic Work Up and Outcomes
Project Summary U.S. women of minority race/ethnicity, lower education, lower income, rural residence, and the underinsured experience higher breast cancer disease burden and lower...
Validation of predictive liquid biomarkers for patients with metastatic prostate cancer
Project Summary/Abstract The University of Wisconsin Carbone Cancer Center (UWCCC), Duke University and Memorial Sloan Kettering Cancer Center (MSKCC) seek support for establishing...
Expanding pharmacological modalities for targeted cancer therapy
Project Summary/Abstract Targeted cancer therapy requires complete and sustained pharmacological inhibition of the respective target, which is often challenging to achieve due to t...