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Interrogating MRCK Protein Kinases in Ovarian Cancer
PROJECT SUMMARY This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-044. Uterine serous carcinoma (USC) is the deadli...
IMAT-ITCR Collaboration: A Cytoscape Toolkit to Model Proteoform-Resolved Cancer Networks
ABSTRACT A single gene can give rise to several alternatively spliced protein isoforms (i.e., proteoforms) that acquire cancer-promoting functions. These cancer-associated proteofo...
Novel Strategy to Augmenting Immunotherapy against Melanoma
PROJECT SUMMARY/ABSTRACT The overarching goal of this R21 proposal is to explore the potential of nelfinavir, a widely used antiviral agent, as a modulator to significantly augment...
Novel MUC1 Theranostic Peptides for Imaging and Treatment of Triple-Negative Breast Cancer
ABSTRACT. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer defined by a poor overall prognosis, aggressive and early pattern of metastases, and a lack...
Development of chemical probe targeting NSD3 SET domain in breast cancer
Abstract Epigenetic abnormalities are common in human cancers and play a critical role in tumorigenesis via dysregulation of gene expression and by affecting chromatin function. Nu...
ATP-responsive Nanoparticles for Reversal of Immune Evasion in Breast Cancer
Summary Antibody-drug conjugates (ADCs) have driven a revolution in the treatment of breast cancer; however, the long-term benefits on patients are still heterogeneous. ADCs induce...
Circulating tumor DNA guided de-escalation of frontline diffuse large B-cell lymphoma therapy
PROJECT SUMMARY The treatment paradigm for newly diagnosed diffuse large B-cell lymphoma (DLBCL) has largely remained unchanged: a uniformly applied regimen of 6 cycles of rituxima...
Deciphering the dichotomy of oxygen metabolism in renal cancer using a novel genetically encoded oxygen biosensor
Abstract Molecular oxygen (O2) plays a crucial role in shaping Earth's biosphere. It is generally accepted that the rise of oxygen in the atmosphere led living systems to evol...
Manipulating Aberrant Calcium Signaling to Target Relapsed High-Risk Neuroblastoma
Project Summary (30 lines) High-risk Neuroblastoma (HRNB) is an extracranial pediatric cancer in which up to 65% of patients are resistant to therapies. Recent biomedical advances...
LiveWell: An Adapted Dialectical Behavioral Therapy Skills Training Protocol for Patients Living with Metastatic Lung Cancer
Patients are living longer with metastatic lung cancer (i.e., metavivors) due to therapeutic advances, but face significant challenges. Most metavivors will ultimately die of cance...
Integration of multi-omics to predict and evaluate response during optimization of a nutrition intervention for cancer survivors with overweight and obesity
PROJECT SUMMARY Cancer survivors with overweight or obesity (ow/ob) display increased morbidity and mortality even after amelioration of disease. Improvements in dietary and physic...
Academic-Industrial Partnership for Barrett's Esophagus Detection and Risk Assessment
Summary. This is a Type 2 R01 renewal application to continue studying Barrett’s esophagus (BE), a premalignant condition wherein the normal squamous esophageal lining is replaced...
The Carolina Endometrial Cancer Study: A population-based survivor cohort
ABSTRACT Endometrial cancer is the 4th most common cancer diagnosed and 6th leading cause of cancer death among United States (U.S.) women. Today, there are more than 891,000 endom...
Cue-101 and TCR-T cell Combinatorial Strategy for HPV+ Head and Neck Cancers
PROJECT SUMMARY Human papillomavirus (HPV) is the causative agent of a growing proportion of incident cases of head and neck squamous cell carcinomas (HNSCCs). HPV type 16 is respo...
An integrated functional proteomics platform for accelerated discovery of isoform-specific determinants of cancer
PROJECT SUMMARY Aberrant splicing is a major mechanism leading to the progression of cancer, and newly emerging experimental and computational approaches reveal a critically import...
Defining Cancer Intervention Targets by Functional Genomics Analysis of Outbred F1 Mice
Our central hypothesis is that targeting regulatory genes of cancer progression will impede tumor growth and prevent disease recurrence. Our study goals are two-fold: to discover c...
Improving bacterial cancer therapeutics
PROJECT SUMMARY (ABSTRACT) Bacterial cancer therapy has existed since Dr. William Coley employed deliberate bacterial infection of tumors over a century ago in the first known exam...
Reprogramming Antigen Presenting Cells in Lymph Nodes to Overcome Tumor Immune Tolerance
Abstract: Most cancer-related deaths are a consequence of metastatic disease. Yet, our understanding of the underlying mechanisms responsible for metastasis—especially the immune s...
Screening for AL Amyloidosis in Smoldering Multiple Myeloma
Abstract Our objective is to develop tools that improve early diagnosis of systemic light-chain (AL) amyloidosis, a disease that causes heart and kidney failure and early death, in...
Robust and Interpretable Multimodal Machine Learning Models for Diagnosis and Prognosis of Prostate Cancer
ABSTRACT Prostate cancer is the second leading cause of cancer death and affects about 13 out of 100 American men. The standard diagnosis approach for prostate cancer incorporates...