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20,252 grants found
Showing 17,161 – 17,180 of 20,252 grants
Chemical Epigenomic Strategies to Overcome Metastatic Castration Resistant Prostate Cancer
ABSTRACT Nuclear receptors are steroid-dependent transcription factors that confer cell identity. They guide development, and maintain homeostasis in adult tissue, such as the test...
Mechanisms of venetoclax combination activity in acute myeloid leukemia
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is one of the most common hematologic malignancies, representing a diverse collection of complex diseases. After 30-40-years w...
Mechanisms of venetoclax combination activity in acute myeloid leukemia
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is one of the most common hematologic malignancies, representing a diverse collection of complex diseases. After 30-40-years w...
Chemical Epigenomic Strategies to Overcome Metastatic Castration Resistant Prostate Cancer
ABSTRACT Nuclear receptors are steroid-dependent transcription factors that confer cell identity.They guide development, and maintain homeostasis in adult tissue, such as the testo...
Organ-on-chip bioreactors for recreating breast to brain metastases
30 line summary: The objective of this proposal is to develop for the scientific community validated assays based on organ on chip systems that will enable interrogating the neuron...
Mechanisms of venetoclax combination activity in acute myeloid leukemia
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is one of the most common hematologic malignancies, representing a diverse collection of complex diseases.After 30-40-years wi...
Improving Family Cancer History Collection using Social Network, Human Centered Design, and Implementation Science Approaches
PROJECT SUMMARY The research strategy and training plan included in this F99/K00 proposal will enhance the career development and research independence of Caitlin G. Allen, MPH.Thi...
Expanding pharmacological modalities for targeted cancer therapy
Project Summary/Abstract Targeted cancer therapy requires complete and sustained pharmacological inhibition of the respective target, which is often challenging to achieve due to t...
Elucidating the role of gut, blood, and tumor microbiota in brain metastasis
Project Summary Brain metastasis is a substantial clinical challenge associated with rising incidence and significant morbidity and mortality. Understanding the mechanisms underlyi...
Modulating extracellular TCR-CD3 interactions to identify new melanoma immunotherapy targets
ABSTRACT Melanoma is one of the deadliest and aggressive form of skin cancer. Main treatment options in metastatic melanoma involve T cell immunotherapy using checkpoint blockade (...
Development of a Standardized Electronic Treatment Plan Builds for NCI-supported Clinical Trials Year 2
Healthcare institutions utilize electronic healthcare records (EHR) to support patients with elaborate treatment plans, specifically those related to oncology regimens.These treatm...
Lentiviral-Induced Swine Model of Spinal Cord Glioma
PROJECT SUMMARY High-grade Spinal Cord Glioma (SCG) is an orphan disease that results in significant morbidity and mortality, with no effective treatment options available. Despite...
CLINICAL TRIALS AND INFORMATION MANAGEMENT SUPPORT
The purpose of this contract is to provide support to the CTEP and CCCT Professional Staff in the evaluation, coordination and oversight of clinical trial concepts and studies as t...
Clinical trial data analysis to design novel treatment regimens in oncology
Project summary Despite the recent development of new treatment modalities in oncology, the overall approval rate for cancer therapeutics is low: only 3% of drugs tested in a phase...
Malawi Cancer Outcomes Research Program (M-CORP)
PROJECT SUMMARY Globally, there are more deaths from cancer than from HIV, tuberculosis, and malaria combined. In 2018, there were more than 18 million new cancer cases and 9.5 mil...
Impact of e-cigarette characteristics and marketing on tobacco use and health: A longitudinal study among U.S. youth and adults
PROJECT SUMMARY/ABSTRACT E-cigarette use has increased rapidly, particularly among youth and young adults. The appealing flavors are a primary reason for young people to initiate a...
IncRNA BORG Mediates Alternative Splicing to Enhance Cellular Plasticity in TNBC
Project Summary/Abstract Breast cancer (BC) is the second leading cause of cancer-related deaths among women in the United States. A subset of BC called triple-negative breast canc...
HTS for the discovery of activators of NK cell cytotoxicity
Abstract Natural killer (NK) cells are lymphocytes that are capable of killing malignant cells without antigen-specific receptor recognition. Due to this property, NK cells have be...
Analysis and Therapeutic Targeting of the Linear-Ubiquitination Pathway in Hodgkin Lymphoma
PROJECT SUMMARY Hodgkin lymphoma (HL) is the most common (6,000 to 7,000 new cases per year) lymphoma subtype in young adulthood. Although there has been great progress during the...
Characterizing and Targeting BAX- and BAK-Dependent Cell Death in Cancer
PROJECT SUMMARY The incorporation of Immune checkpoint blockade into anticancer armamentarium has revolutionized cancer therapy in recent years, with FDA approved agents in multipl...