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20,252 grants found
Showing 17,141 – 17,160 of 20,252 grants
Leveraging canine spontaneous cancer to optimize the power of blood biopsy
PROJECT SUMMARY Recent technological advances have driven the development of novel, less invasive approaches for assessing the tumor genome. In particular, the “blood biopsy” which...
Dynamic Complexity of Brain Tumor Stem Cells (R35CA197718)
?DESCRIPTION (provided by applicant): Glioblastomas rank among the most lethal of human cancers despite aggressive multimodal therapy.Most cancers kill their hosts through metastas...
Early investigation of the role of desmoplastic fibrosis in cutaneous squamous cell carcinoma
Project Summary/Abstract The only FDA-approved treatment for advanced cutaneous squamous cell carcinoma (CSCC) (cemiplimab, an immunotherapy drug that helps the immune system kill...
Predictive and Diagnostic Radiomic Signatures in Non-Small Cell Lung Cancer (NSCLC) on Immunotherapy
PROJECT SUMMARY We propose to identify novel radiomic signatures of anti-programmed death ligand 1 (PDL1)/PD1 therapy response for non-small cell lung cancer (NSCLC) and evaluate h...
Targeting m6A RNA epigenetics in treatment-emergent neuroendocrine prostate cancer
Project Summary/Abstract Castration-resistant prostate cancer is associated with substantial clinical, pathologic, and molecular heterogeneity; most tumors remain driven by androge...
Mechanisms of protein degradation that control signal transduction by Ras-Raf-MEK-ERK
Project Summary This proposal aims to discover mechanistic insights into how signal transduction by the highly conserved Ras-Raf-MEK-ERK pathway is modulated by regulated protein d...
Early investigation of the role of desmoplastic fibrosis in cutaneous squamous cell carcinoma
Project Summary/Abstract The only FDA-approved treatment for advanced cutaneous squamous cell carcinoma (CSCC) (cemiplimab, an immunotherapy drug that helps the immune system kill...
Mechanisms of protein degradation that control signal transduction by Ras-Raf-MEK-ERK
Project Summary This proposal aims to discover mechanistic insights into how signal transduction by the highly conserved Ras-Raf-MEK-ERK pathway is modulated by regulated protein d...
Targeting m6A RNA epigenetics in treatment-emergent neuroendocrine prostate cancer
Project Summary/Abstract Castration-resistant prostate cancer is associated with substantial clinical, pathologic, and molecular heterogeneity; most tumors remain driven by androge...
Predictive and Diagnostic Radiomic Signatures in Non-Small Cell Lung Cancer (NSCLC) on Immunotherapy
PROJECT SUMMARY We propose to identify novel radiomic signatures of anti-programmed death ligand 1 (PDL1)/PD1 therapy response for non-small cell lung cancer (NSCLC) and evaluate h...
Predictive and Diagnostic Radiomic Signatures in Non-Small Cell Lung Cancer (NSCLC) on Immunotherapy
PROJECT SUMMARY We propose to identify novel radiomic signatures of anti-programmed death ligand 1 (PDL1)/PD1 therapy response for non-small cell lung cancer (NSCLC) and evaluate h...
Targeting m6A RNA epigenetics in treatment-emergent neuroendocrine prostate cancer
Project Summary/Abstract Castration-resistant prostate cancer is associated with substantial clinical, pathologic, and molecular heterogeneity; most tumors remain driven by androge...
Targeting m6A RNA epigenetics in treatment-emergent neuroendocrine prostate cancer
Project Summary/Abstract Castration-resistant prostate cancer is associated with substantial clinical, pathologic, and molecular heterogeneity; most tumors remain driven by androge...
Single-Cell Transcriptome & Effect of Immune Checkpoint Therapy on Kaposi Sarcoma
Abstract ?Single-Cell Transcriptome & Effect of Immune Checkpoint Therapy on Kaposi Sarcoma Kaposi Sarcoma (KS) is a malignancy resulting from KS ?-herpresvirus (KSHV) infectio...
Device for Preservation of Cell Free RNA in Saliva
ABSTRACT Early detection is critical to cancer mortality reductions, and yet the breast imaging clinic visits required for these life-saving early detection programs are inaccessib...
Single-Cell Transcriptome & Effect of Immune Checkpoint Therapy on Kaposi Sarcoma
Abstract – Single-Cell Transcriptome & Effect of Immune Checkpoint Therapy on Kaposi Sarcoma Kaposi Sarcoma (KS) is a malignancy resulting from KS γ-herpresvirus (KSHV) infecti...
Device for Preservation of Cell Free RNA in Saliva
ABSTRACT Early detection is critical to cancer mortality reductions, and yet the breast imaging clinic visits required for these life-saving early detection programs are inaccessib...
Chemical Epigenomic Strategies to Overcome Metastatic Castration Resistant Prostate Cancer
ABSTRACT Nuclear receptors are steroid-dependent transcription factors that confer cell identity. They guide development, and maintain homeostasis in adult tissue, such as the test...
Organ-on-chip bioreactors for recreating breast to brain metastases
30 line summary: The objective of this proposal is to develop for the scientific community validated assays based on organ on chip systems that will enable interrogating the neuron...
Mechanisms of venetoclax combination activity in acute myeloid leukemia
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is one of the most common hematologic malignancies, representing a diverse collection of complex diseases. After 30-40-years w...