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20,252 grants found
Showing 17,121 – 17,140 of 20,252 grants
InSiGHT-ClinGen Polyposis/Colon Cancer Variant Curation Expert Panel
ABSTRACT: InSiGHT-ClinGen Polyposis /Colon Cancer (ICPC) Variant Curation Expert Panel (VCEP) The goal of the InSiGHT-ClinGen Polyposis /Colon Cancer (ICPC) Variant Curation Expert...
Tyrosine phosphorylation of p27Kip1 as a biomarker to identify Cdk4/6 inhibitor response
SUMMARY While the CDK4 targeting drugs (CDK4i), Palbociclib, Abemaciclib, and Ribociclib, have shown clinical promise in the treatment of metastatic breast cancer (BC), lack of a c...
Investigating PolQ-mediated alternative NHEJ in breast cancer
Chromosomal rearrangements are a hallmark of cancer cells and constitute a major pathway by which genes that affect tumor initiation and progression become mutated. Such aberrancie...
Investigating PolQ-mediated alternative NHEJ in breast cancer
Chromosomal rearrangements are a hallmark of cancer cells and constitute a major pathway by which genes that affect tumor initiation and progression become mutated. Such aberrancie...
Fetal Origins of Testicular Cancer: A Metabolomics Study in Newborns
PROJECT SUMMARY/ABSTRACT Testicular cancer, mainly comprised of testicular germ cell tumors (TGCT), is the most common solid tumor among adolescent and young adult males. Its incid...
InSiGHT-ClinGen Polyposis/Colon Cancer Variant Curation Expert Panel
ABSTRACT: InSiGHT-ClinGen Polyposis /Colon Cancer (ICPC) Variant Curation Expert Panel (VCEP) The goal of the InSiGHT-ClinGen Polyposis /Colon Cancer (ICPC) Variant Curation Expert...
Tyrosine phosphorylation of p27Kip1 as a biomarker to identify Cdk4/6 inhibitor response
SUMMARY While the CDK4 targeting drugs (CDK4i), Palbociclib, Abemaciclib, and Ribociclib, have shown clinical promise in the treatment of metastatic breast cancer (BC), lack of a c...
Investigating PolQ-mediated alternative NHEJ in breast cancer
Chromosomal rearrangements are a hallmark of cancer cells and constitute a major pathway by which genes that affect tumor initiation and progression become mutated. Such aberrancie...
InSiGHT-ClinGen Polyposis/Colon Cancer Variant Curation Expert Panel
ABSTRACT: InSiGHT-ClinGen Polyposis /Colon Cancer (ICPC) Variant Curation Expert Panel (VCEP) The goal of the InSiGHT-ClinGen Polyposis /Colon Cancer (ICPC) Variant Curation Expert...
Tyrosine phosphorylation of p27Kip1 as a biomarker to identify Cdk4/6 inhibitor response
SUMMARY While the CDK4 targeting drugs (CDK4i), Palbociclib, Abemaciclib, and Ribociclib, have shown clinical promise in the treatment of metastatic breast cancer (BC), lack of a c...
InSiGHT-ClinGen Polyposis/Colon Cancer Variant Curation Expert Panel
ABSTRACT: InSiGHT-ClinGen Polyposis /Colon Cancer (ICPC) Variant Curation Expert Panel (VCEP) The goal of the InSiGHT-ClinGen Polyposis /Colon Cancer (ICPC) Variant Curation Expert...
TLR7/8 agonist design and delivery for effective anticancer immune response
Agonists of toll like receptors (TLRs) are promising anticancer vaccine adjuvants because of their ability to induce proinflammatory cytokines necessary to generate a robust immune...
TLR7/8 agonist design and delivery for effective anticancer immune response
Agonists of toll like receptors (TLRs) are promising anticancer vaccine adjuvants because of their ability to induce proinflammatory cytokines necessary to generate a robust immune...
TLR7/8 agonist design and delivery for effective anticancer immune response
Agonists of toll like receptors (TLRs) are promising anticancer vaccine adjuvants because of their ability to induce proinflammatory cytokines necessary to generate a robust immune...
TLR7/8 agonist design and delivery for effective anticancer immune response
Agonists of toll like receptors (TLRs) are promising anticancer vaccine adjuvants because of their ability to induce proinflammatory cytokines necessary to generate a robust immune...
Leveraging canine spontaneous cancer to optimize the power of blood biopsy
PROJECT SUMMARY Recent technological advances have driven the development of novel, less invasive approaches for assessing the tumor genome. In particular, the “blood biopsy” which...
Leveraging canine spontaneous cancer to optimize the power of blood biopsy
PROJECT SUMMARY Recent technological advances have driven the development of novel, less invasive approaches for assessing the tumor genome.In particular, the ?blood biopsy? which...
Leveraging canine spontaneous cancer to optimize the power of blood biopsy
PROJECT SUMMARY Recent technological advances have driven the development of novel, less invasive approaches for assessing the tumor genome. In particular, the “blood biopsy” which...
Connecting individual-level environmental exposures to cancer-related outcomes in a shorter-lived natural model system
Following a train derailment in East Palestine, Ohio on February 3, 2023, more than 100,000 gallons of hazardous chemicals consisting of vinyl chloride and other carcinogens were r...
Leveraging canine spontaneous cancer to optimize the power of blood biopsy
ABSTRACT Blood biopsy is a rapidly advancing technology in which circulating elements (DNA, RNA, proteins, exosomes) released from tumor cells are collected and assessed. In most c...