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20,252 grants found
Showing 17,101 – 17,120 of 20,252 grants
Mechanisms of cell death in cutaneous melanoma
PROJECT SUMMARY The incidence of cutaneous melanoma is rising. While small molecule targeted inhibitors and immune checkpoint antibodies have increased long-term survival in advanc...
Targeting Neuron-Microglia Interactions at the Margin of Glioma
PROJECT SUMMARY/ABSTRACT Recent studies have revealed that crosstalk between glioma cells and the brain microenvironment is a crucial regulator of cancer initiation and progression...
Drugging EBNA1 to Treat EBV-Associated Cancers
Project Summary EBV latent infection is responsible for ~200,000 new cancers per year. To date, there are no EBV- specific therapeutic agents that selectively and efficaciously tre...
Sensitivity of Abi1/Pten null tumors to taxane and anti-androgen receptor therapy
ABSTRACT Prostate cancer (PCa) is the most frequently diagnosed cancer in American men and the 2nd leading cause of male cancer-related deaths in the U.S. Indolent localized PCa is...
Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators
ABSTRACT Combining fasting with chemotherapy can cause complete tumor regression in animal models. Acute fasting is thought to sensitize tumor cells to the cytotoxic effects of che...
Reducing cervical cancer screening disparities in Somali immigrant women through a primary care based HPV self-sampling intervention
SUMMARY/ABSTRACT Somali women living in the U.S. have lower cervical cancer screening rates than the U.S. general female population. This disparity is due to a range of factors, in...
Development of a low-cost epigenetic screening assay for Pap specimen-based detection of early-stage ovarian cancer in high-risk women
PROJECT SUMMARY With a 5-year survival rate of only 47%, high-grade serous carcinoma (HGSC) remains the most lethal of all types of ovarian cancer. This is a particular concern for...
Targeting Neuron-Microglia Interactions at the Margin of Glioma
PROJECT SUMMARY/ABSTRACT Recent studies have revealed that crosstalk between glioma cells and the brain microenvironment is a crucial regulator of cancer initiation and progression...
Reducing cervical cancer screening disparities in Somali immigrant women through a primary care based HPV self-sampling intervention
SUMMARY/ABSTRACT Somali women living in the U.S. have lower cervical cancer screening rates than the U.S. general female population. This disparity is due to a range of factors, in...
Validation of Epigenomic Biomarkers for Thyroid Cancer Diagnostics
ABSTRACT Thyroid cancer is less frequent but deadlier for individuals who self-identify as African American/ Black or Latino/Hispanic in comparison to individuals who self-identify...
Imaging zinc secretion from the exocrine pancreas for the early diagnosis of pancreatic adenocarcinoma with MRI
PROJECT SUMMARY/ABSTRACT This proposal aims to use noninvasive molecular magnetic resonance (MR) imaging of pancreatic zinc content and secretion to detect pancreatic intraepitheli...
Development of a radiation-activatable nanoparticle for lung cancer therapy
ABSTRACT Non?small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality. NSCLC accounts for 85% of all lung cancers, and is diagnosed in 234,030 persons each yea...
Imaging zinc secretion from the exocrine pancreas for the early diagnosis of pancreatic adenocarcinoma with MRI
PROJECT SUMMARY/ABSTRACT This proposal aims to use noninvasive molecular magnetic resonance (MR) imaging of pancreatic zinc content and secretion to detect pancreatic intraepitheli...
Imaging zinc secretion from the exocrine pancreas for the early diagnosis of pancreatic adenocarcinoma with MRI
PROJECT SUMMARY/ABSTRACT This proposal aims to use noninvasive molecular magnetic resonance (MR) imaging of pancreatic zinc content and secretion to detect pancreatic intraepitheli...
CAR NKT Cell Immunotherapy of Neuroblastoma
Abstract Despite remarkable progress in treating B cell malignancies, T cells expressing chimeric antigen receptors (CARs) remain largely ineffective in solid tumors.We demonstrate...
CAR NKT Cell Immunotherapy of Neuroblastoma
Abstract Despite remarkable progress in treating B cell malignancies, T cells expressing chimeric antigen receptors (CARs) remain largely ineffective in solid tumors. We demonstrat...
CAR NKT Cell Immunotherapy of Neuroblastoma
Abstract Despite remarkable progress in treating B cell malignancies, T cells expressing chimeric antigen receptors (CARs) remain largely ineffective in solid tumors. We demonstrat...
CAR NKT Cell Immunotherapy of Neuroblastoma
Abstract Despite remarkable progress in treating B cell malignancies, T cells expressing chimeric antigen receptors (CARs) remain largely ineffective in solid tumors. We demonstrat...
Florida Cancer ReTOOL Program for Underrepresented Minority Students
ABSTRACT The underrepresentation of minorities in basic, clinical and behavioral research has been viewed as a significant barrier to addressing cancer disparities, and the inclusi...
Fetal Origins of Testicular Cancer: A Metabolomics Study in Newborns
PROJECT SUMMARY/ABSTRACT Testicular cancer, mainly comprised of testicular germ cell tumors (TGCT), is the most common solid tumor among adolescent and young adult males. Its incid...