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20,252 grants found
Showing 17,081 – 17,100 of 20,252 grants
Regulation of tumor-infiltrating T cells by macrophages
Project Abstract Tumor-associated macrophages (TAMs), a major component of the tumor stromal mass, demonstrate great phenotypic heterogeneity and diverse functional capabilities un...
Validation of epigenomic biomarkers for thyroid cancer diagnostics
PROJECT SUMMARY/ABSTRACT Each year, up to 50,000 patients in the United States receive unnecessary thyroidectomies.These unnecessary thyroidectomies are due to difficulties in preo...
Ultrasound-Controlled Immunotherapy for Targeted Treatment of Solid Tumors
Project Summary Advances in synthetic biology have enabled the development of increasing numbers of cell-based diagnostic and therapeutic tools.However, controlling these cells in...
Degrading therapeutically important kinases using small molecules
Targeting of oncogenic kinases with small molecule inhibitors is now a well validated paradigm for treatment of cancer types and approximately 25 drugs directed at targets such as...
Degrading therapeutically important kinases using small molecules
Targeting of oncogenic kinases with small molecule inhibitors is now a well validated paradigm for treatment of cancer types and approximately 25 drugs directed at targets such as...
Raf-1 As a Regulator of Glutamine Metabolism
PROJECT SUMMARY The Ras proteins are frequently mutated in cancer to activate diverse signaling pathways necessary for uncontrolled cellular proliferation, including pathways respo...
Bioengineering programmable and drug-controllable synthetic receptors fortunable CAR-T cell behaviors
Project Summary Chimeric Antigen Receptor (CAR)-T cell therapy has had unprecedented success in patients with B- cell malignancies, demonstrating upwards of 100% complete remission...
Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators
ABSTRACT Combining fasting with chemotherapy can cause complete tumor regression in animal models.Acute fasting is thought to sensitize tumor cells to the cytotoxic effects of chem...
(PQ3) Addressing Cancer Treatment Disparities for Persons with HIV
PROJECT SUMMARY/ABSTRACT The introduction of combination antiretroviral therapy (ART) has led to a dramatic decline in AIDS-associated mortality. However, as persons with HIV (PWH)...
(PQ3) Addressing Cancer Treatment Disparities for Persons with HIV
PROJECT SUMMARY/ABSTRACT The introduction of combination antiretroviral therapy (ART) has led to a dramatic decline in AIDS-associated mortality.However, as persons with HIV (PWH)...
Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators
ABSTRACT Combining fasting with chemotherapy can cause complete tumor regression in animal models. Acute fasting is thought to sensitize tumor cells to the cytotoxic effects of che...
Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators
ABSTRACT Combining fasting with chemotherapy can cause complete tumor regression in animal models. Acute fasting is thought to sensitize tumor cells to the cytotoxic effects of che...
Reducing cervical cancer screening disparities in Somali immigrant women through a primary care based HPV self-sampling intervention
SUMMARY/ABSTRACT Somali women living in the U.S. have lower cervical cancer screening rates than the U.S. general female population. This disparity is due to a range of factors, in...
Drugging EBNA1 to Treat EBV-Associated Cancers
Project Summary EBV latent infection is responsible for ~200,000 new cancers per year. To date, there are no EBV- specific therapeutic agents that selectively and efficaciously tre...
Development of a low-cost epigenetic screening assay for Pap specimen-based detection of early-stage ovarian cancer in high-risk women
PROJECT SUMMARY With a 5-year survival rate of only 47%, high-grade serous carcinoma (HGSC) remains the most lethal of all types of ovarian cancer. This is a particular concern for...
Reducing cervical cancer screening disparities in Somali immigrant women through a primary care based HPV self-sampling intervention
SUMMARY/ABSTRACT Somali women living in the U.S. have lower cervical cancer screening rates than the U.S. general female population. This disparity is due to a range of factors, in...
Reducing cervical cancer screening disparities in Somali immigrant women through a primary care based HPV self-sampling intervention
SUMMARY/ABSTRACT Somali women living in the U.S. have lower cervical cancer screening rates than the U.S. general female population. This disparity is due to a range of factors, in...
Drugging EBNA1 to Treat EBV-Associated Cancers - Diversity Supplement
Project Summary EBV latent infection is responsible for ~200,000 new cancers per year. To date, there are no EBV- specific therapeutic agents that selectively and efficaciously tre...
Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape
Although the approval of novel targeted therapy drugs, such as BRAF inhibitors (BRAFi), MEK inhibitors (MEKi), and immune checkpoint inhibitors, has revolutionized melanoma treatme...
Regulation of tumor-infiltrating T cells by macrophages
Project Abstract Tumor-associated macrophages (TAMs), a major component of the tumor stromal mass, demonstrate great phenotypic heterogeneity and diverse functional capabilities un...