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20,252 grants found
Showing 17,061 – 17,080 of 20,252 grants
Drugging EBNA1 to Treat EBV-Associated Cancers
Project Summary EBV latent infection is responsible for ~200,000 new cancers per year. To date, there are no EBV- specific therapeutic agents that selectively and efficaciously tre...
Sensitivity of Abi1/Pten null tumors to taxane and anti-androgen receptor therapy
ABSTRACT Prostate cancer (PCa) is the most frequently diagnosed cancer in American men and the 2nd leading cause of male cancer-related deaths in the U.S. Indolent localized PCa is...
Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape
Although the approval of novel targeted therapy drugs, such as BRAF inhibitors (BRAFi), MEK inhibitors (MEKi), and immune checkpoint inhibitors, has revolutionized melanoma treatme...
NAD+ metabolism in PARP inhibitor resistance of ovarian cancer
PROJECT SUMMARY/ABSTRACT High-grade serous ovarian cancer (HGSOC) remains the deadliest form of ovarian cancer, in part because most patients develop recurrent disease that is resi...
Regulation of tumor-infiltrating T cells by macrophages
Project Abstract Tumor-associated macrophages (TAMs), a major component of the tumor stromal mass, demonstrate great phenotypic heterogeneity and diverse functional capabilities un...
Validation of epigenomic biomarkers for thyroid cancer diagnostics
PROJECT SUMMARY/ABSTRACT Each year, up to 50,000 patients in the United States receive unnecessary thyroidectomies. These unnecessary thyroidectomies are due to difficulties in pre...
Degrading therapeutically important kinases using small molecules
Targeting of oncogenic kinases with small molecule inhibitors is now a well validated paradigm for treatment of cancer types and approximately 25 drugs directed at targets such as...
Mechanisms of cell death in cutaneous melanoma
PROJECT SUMMARY The incidence of cutaneous melanoma is rising. While small molecule targeted inhibitors and immune checkpoint antibodies have increased long-term survival in advanc...
NAD+ metabolism in PARP inhibitor resistance of ovarian cancer
PROJECT SUMMARY/ABSTRACT High-grade serous ovarian cancer (HGSOC) remains the deadliest form of ovarian cancer, in part because most patients develop recurrent disease that is resi...
(PQ3) Addressing Cancer Treatment Disparities for Persons with HIV
PROJECT SUMMARY/ABSTRACT The introduction of combination antiretroviral therapy (ART) has led to a dramatic decline in AIDS-associated mortality. However, as persons with HIV (PWH)...
Bioengineering programmable and drug-controllable synthetic receptors fortunable CAR-T cell behaviors
Project Summary Chimeric Antigen Receptor (CAR)-T cell therapy has had unprecedented success in patients with B- cell malignancies, demonstrating upwards of 100% complete remission...
Regulation of tumor-infiltrating T cells by macrophages
Project Abstract Tumor-associated macrophages (TAMs), a major component of the tumor stromal mass, demonstrate great phenotypic heterogeneity and diverse functional capabilities un...
Drugging EBNA1 to Treat EBV-Associated Cancers
Project Summary EBV latent infection is responsible for ~200,000 new cancers per year. To date, there are no EBV- specific therapeutic agents that selectively and efficaciously tre...
Drugging EBNA1 to Treat EBV-Associated Cancers
Project Summary EBV latent infection is responsible for ~200,000 new cancers per year. To date, there are no EBV- specific therapeutic agents that selectively and efficaciously tre...
Targeting Neuron-Microglia Interactions at the Margin of Glioma
PROJECT SUMMARY/ABSTRACT Recent studies have revealed that crosstalk between glioma cells and the brain microenvironment is a crucial regulator of cancer initiation and progression...
Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape
Although the approval of novel targeted therapy drugs, such as BRAF inhibitors (BRAFi), MEK inhibitors (MEKi), and immune checkpoint inhibitors, has revolutionized melanoma treatme...
Validation of epigenomic biomarkers for thyroid cancer diagnostics
PROJECT SUMMARY/ABSTRACT Each year, up to 50,000 patients in the United States receive unnecessary thyroidectomies. These unnecessary thyroidectomies are due to difficulties in pre...
(PQ3) Addressing Cancer Treatment Disparities for Persons with HIV
PROJECT SUMMARY/ABSTRACT The introduction of combination antiretroviral therapy (ART) has led to a dramatic decline in AIDS-associated mortality. However, as persons with HIV (PWH)...
NAD+ metabolism in PARP inhibitor resistance of ovarian cancer
PROJECT SUMMARY/ABSTRACT High-grade serous ovarian cancer (HGSOC) remains the deadliest form of ovarian cancer, in part because most patients develop recurrent disease that is resi...
Reprogramming of the stromal microenvironment in melanoma progression and therapeutic escape
Although the approval of novel targeted therapy drugs, such as BRAF inhibitors (BRAFi), MEK inhibitors (MEKi), and immune checkpoint inhibitors, has revolutionized melanoma treatme...