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20,252 grants found
Showing 17,041 – 17,060 of 20,252 grants
Mechanisms of epigenetic regulation of estrogen receptor function in breast cancer
PROJECT SUMMARY/ ABSTRACT CANDIDATE: My ultimate goal is to become a principal investigator focused on the epigenetic mechanisms driving the pathogenesis of human diseases.I seek t...
Mechanisms of epigenetic regulation of estrogen receptor function in breast cancer
PROJECT SUMMARY/ ABSTRACT CANDIDATE: My ultimate goal is to become a principal investigator focused on the epigenetic mechanisms driving the pathogenesis of human diseases. I seek...
Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores
Abstract There are stark differences in the burden of certain cancers across racial/ethnic populations. For example, in comparison to individuals of European ancestry, African Amer...
Study of the IL-33-driven immune cell organization underpinning responses to immune checkpoint blockade cancer therapy
The immune checkpoint blockade cancer therapy (ICB) can greatly prolong survival in responders. However, significant improvement of the response rate of ICB is in urgent need. We h...
Mechanisms of epigenetic regulation of estrogen receptor function in breast cancer
PROJECT SUMMARY/ ABSTRACT CANDIDATE: My ultimate goal is to become a principal investigator focused on the epigenetic mechanisms driving the pathogenesis of human diseases. I seek...
Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores
Abstract There are stark differences in the burden of certain cancers across racial/ethnic populations. For example, in comparison to individuals of European ancestry, African Amer...
Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores
Abstract There are stark differences in the burden of certain cancers across racial/ethnic populations.For example, in comparison to individuals of European ancestry, African Ameri...
Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores
Abstract There are stark differences in the burden of certain cancers across racial/ethnic populations. For example, in comparison to individuals of European ancestry, African Amer...
Study of the IL-33-driven immune cell organization underpinning responses to immune checkpoint blockade cancer therapy
The immune checkpoint blockade cancer therapy (ICB) can greatly prolong survival in responders. However, significant improvement of the response rate of ICB is in urgent need.We ha...
Raf-1 As a Regulator of Glutamine Metabolism
PROJECT SUMMARY The Ras proteins are frequently mutated in cancer to activate diverse signaling pathways necessary for uncontrolled cellular proliferation, including pathways respo...
Bioengineering programmable and drug-controllable synthetic receptors fortunable CAR-T cell behaviors
Project Summary Chimeric Antigen Receptor (CAR)-T cell therapy has had unprecedented success in patients with B- cell malignancies, demonstrating upwards of 100% complete remission...
Mechanisms of cell death in cutaneous melanoma
PROJECT SUMMARY The incidence of cutaneous melanoma is rising.While small molecule targeted inhibitors and immune checkpoint antibodies have increased long-term survival in advance...
Development of a low-cost epigenetic screening assay for Pap specimen-based detection of early-stage ovarian cancer in high-risk women
PROJECT SUMMARY With a 5-year survival rate of only 47%, high-grade serous carcinoma (HGSC) remains the most lethal of all types of ovarian cancer.This is a particular concern for...
Ultrasound-Controlled Immunotherapy for Targeted Treatment of Solid Tumors
Project Summary Advances in synthetic biology have enabled the development of increasing numbers of cell-based diagnostic and therapeutic tools. However, controlling these cells in...
Targeting Neuron-Microglia Interactions at the Margin of Glioma
PROJECT SUMMARY/ABSTRACT Recent studies have revealed that crosstalk between glioma cells and the brain microenvironment is a crucial regulator of cancer initiation and progression...
Reducing cervical cancer screening disparities in Somali immigrant women through a primary care based HPV self-sampling intervention
SUMMARY/ABSTRACT Somali women living in the U.S. have lower cervical cancer screening rates than the U.S. general female population. This disparity is due to a range of factors, in...
NAD+ metabolism in PARP inhibitor resistance of ovarian cancer
PROJECT SUMMARY/ABSTRACT High-grade serous ovarian cancer (HGSOC) remains the deadliest form of ovarian cancer, in part because most patients develop recurrent disease that is resi...
Reducing cervical cancer screening disparities in Somali immigrant women through a primary care based HPV self-sampling intervention
SUMMARY/ABSTRACT Somali women living in the U.S. have lower cervical cancer screening rates than the U.S. general female population.This disparity is due to a range of factors, inc...
Development of a low-cost epigenetic screening assay for Pap specimen-based detection of early-stage ovarian cancer in high-risk women
PROJECT SUMMARY With a 5-year survival rate of only 47%, high-grade serous carcinoma (HGSC) remains the most lethal of all types of ovarian cancer. This is a particular concern for...
Mechanisms of cell death in cutaneous melanoma
PROJECT SUMMARY The incidence of cutaneous melanoma is rising. While small molecule targeted inhibitors and immune checkpoint antibodies have increased long-term survival in advanc...