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20,252 grants found
Showing 1,681 – 1,700 of 20,252 grants
Interrogation of the oxidative-stress-induced leukemia program in vivo usingmetabolic imaging
PROJECT SUMMARY/ABSTRACT (unchanged from initial application) Acute myeloid leukemia (AML) is a genetically complex and heterogeneous set of diseases characterized by a diverse set...
PA-23-189 for Kaya Johnson to CA260126-01: Identifying a proteomic signature for breast cancer detection in breast milk and serum
Program Director/Principal Investigator (Last, First, Middle): Darie, Costel C. Supplement Application (PAR-18-714) for Candidate Kaya Johnson Funded parent grant CA260126-01: Iden...
Empowering Latinas to Obtain Guideline-Concordant Breast Cancer Screenings
ABSTRACT Proposed Research Plan. Latinas are less likely to receive timely diagnostic care and are more likely to experience greater psychosocial distress following screening mammo...
Clinical Protocol and Data Management
CLINICAL PROTOCOL AND DATA MANAGEMENT PROJECT SUMMARY The Mayo Clinic Cancer Center (MCCC) Clinical Protocol and Data Management (CPDM) functions are administratively overseen by t...
Development of First-in-Class RIPK1 Degraders to Improve Cancer Immunotherapies
Abstract Cancer immunotherapies have achieved unprecedented clinical responses and are revolutionizing cancer treatments. Despite of the tremendous success of cancer immunotherapie...
Selective Radionuclide Delivery for Precise Bone Marrow Niche Alterations - Admin Supplement
PROJECT SUMMARY / ABSTRACT (From Parent Grant Application) The bone marrow niche houses hematopoietic stem cells (HSCs), cells that self-renew and differentiate into vital blood co...
Exploring microRNA degradation in T-cell acute lymphoblastic leukemia
PROJECT SUMMARY Gene expression, the flow of genetic information from DNA to messenger RNA (mRNA) to protein, involves delicate regulation by a group of small RNAs named microRNAs....
Refining and expanding breast dosimetry for the Sacramento Area Breast Imaging Registry
Abstract The SABIR (Sacramento Area Breast Imaging Registry) was created to provide insights regarding the best approaches for breast cancer screening, surveillance, and to compare...
Enhancing Melanoma TIL Efficacy with Multifactor mRNA-Mediated T Cell Reprogramming
Refer to Parent Grant SUMMARY AND SPECIFIC AIMS OF PARENT GRANT (R21CA282629, PI: KATZ). Although T cell mediated immune responses are critical for successful immunotherapy, T cell...
Identification of metabolic adducts associated with prostate cancer progression in African American men Supplement
Abstract Prostate cancer (PCa) is the second highest cause of cancer-related deaths in men. African American/Black (AA/B) men are disproportionally impacted by PCa with a 60% highe...
Supplement to Promote Diversity: Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
No Changes to the Abstract Chemotherapy-related cognitive impairment (CRCI, chemobrain), chemotherapy-induced peripheral neuropathy (CIPN) and gait changes are debilitating side-ef...
Diversity Supplements for Imaging Research in Prostate Cancer Health Disparities
PROJECT SUMMARY African American (AA) men face the highest incidence and mortality rates from prostate cancer (PCa) in the United States. Prostate multi-parametric MRI (mpMRI) is a...
Improvement of cellular immunotherapy during dysbiosis - A. A. Brint Supplement
Project Summary The use of antibiotics has significantly increased in recent years. Antibiotics (ABX) severely alter the gut microbiome, destroying potentially pathogenic bacteria,...
In vivo imaging of mitochondria structure and function in therapy resistant lung tumors
Abstract The overarching goal of this study is to identify effective metabolic based diagnostic and therapeutic strategies to improve the overall survival of patients with Non-smal...
Tumor-associated macrophage reprogramming through PARP14 inhibition in muscle-invasive bladder cancer
Project summary This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-21-100. This NCI Early-stage Surgeon Scientist Program...
The second phase of NIH Common Fund 4D Nucleome Network Organizational Hub
The second phase of NIH Common Fund 4D Nucleome Network Organizational Hub Abstract The second phase of the 4DN program requires an efficient organizational center to synergize the...
Targeting Kinase Inhibitor Induced Signaling Plasticity in Patients with Ph-Like ALL
Project Summary Major scientific and therapeutic advances have improved outcomes of patients with B-cell acute lymphoblastic leukemia (B-ALL) over the last four decades. Addition o...
Mayo Comprehensive Cancer Center Grant (Funded Extension Supplement)
OVERALL PROJECT SUMMARY The Mayo Clinic Comprehensive Cancer Center (MCCCC) has engaged in intensive strategic planning and evaluation efforts, formed a new External Scientific Adv...
REGISTRATION, STORAGE AND DISTRIBUTION OF CHEMICALS AND DRUGS FOR PRE-CLINICAL DISCOVERY, EVALUATION AND DEVELOPMENT
The purpose of this contract is to operate and maintain the National Cancer Institute's Chemotherapeutic Agents Repository (NCI-CAR). The principal goals of this contract are...
P30 Administrative Supplement for Assessing and Enhancing Survivorship Care
PROJECT ABSTRACT The complexity of childhood cancer survivorship care delivery necessitates systematic optimization, especially as the U.S. survivor population approaches 580,000....