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20,252 grants found
Showing 16,961 – 16,980 of 20,252 grants
Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer
PROJECT SUMMARY Tumor heterogeneity is the main cause of resistance to current chemotherapy drugs as well as metastasis development, leading to patients' death. Within the sam...
Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancer
Project Summary Resistance to therapy is the major challenge for the treatment of pancreatic cancer. Despite recent successes in immune checkpoint therapy of several human cancer t...
Realizing the radiobiological impact of protons and high-LET particles in head and neck cancer and glioblastoma models
Project Summary Radiotherapy is still one of the most effective cancer treatments used to treatment ~50 % of all human cancers, and particularly solid tumours of the head and neck...
Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer
PROJECT SUMMARY Tumor heterogeneity is the main cause of resistance to current chemotherapy drugs as well as metastasis development, leading to patients' death. Within the sam...
Persistent STAT5 signaling in polyfunctional CD4 T cells and its application in adoptive T cell therapy
Project summary/abstract Recent advances in adoptive T-cell therapy (ACT), especially CD19-targeting chimeric antigen receptor (CAR) T-cell therapy (CD19CART), have highlighted the...
AN INTEGRATED PLATFORM FOR NOVEL PERSONALIZED LIVER CANCER THERAPEUTICS
SUMMARY Liver cancer is the fourth leading cause of cancer related mortality worldwide. Currently, in addition to emerging immune checkpoint inhibitors, a small number of structura...
Elucidating the role of DNAPKcs in chromosomal break end joining and clastogen resistance
SUMMARY. Kinase inhibitors targeting the catalytic subunit of the DNA-dependent protein kinase (DNAPKcs) are being developed to sensitize tumors to clastogenic (chromosomal-breakin...
Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
Chemotherapy-related cognitive impairment (CRCI, chemobrain), chemotherapy-induced peripheral neuropathy (CIPN) and gait changes are debilitating side-effects of cancer treatment w...
Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
Chemotherapy-related cognitive impairment (CRCI, chemobrain), chemotherapy-induced peripheral neuropathy (CIPN) and gait changes are debilitating side-effects of cancer treatment w...
Improving the translational value of head and neck cancer patient-in-mouse models
Project Summary Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer. Our goal is to improve the use of mammali...
Diagnosis of Cancer in the Emergency Room - Explaining Persistent Disparities - Diversity Supplement
Abstract Cancer is a common diagnosis in the emergency department (ED) and by the time patients reach the ED, their cancer hasoften progressed to later stages. Lung cancer is the d...
Targeting TET DNA Dioxygenases as Therapeutic Principle in Myeloid Neoplasms
PROJECT SUMMARY/ABSTRACT Ten Eleven Translocation (TET1, TET2 and TET3) are α-ketoglutarate (αKG) and Fe2+ dependent DNA- dioxygenases that is a key regulator of epigenetic landsca...
Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDA) is projected to become the 2nd leading cause of cancer-related deaths world-wide by 2030, largely due a lack of effe...
In Vivo Testing of Novel Drug Combinations for Pediatric Soft Tissue Sarcomas
PROJECT SUMMARY Despite the advances made in our understanding of the etiology of pediatric soft tissue sarcomas (STS), the overall survival of those diseases has not significantly...
Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma
Project Summary Given advances in screening and treatment, the number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) by 2030...
Improving the Timeliness and Quality of Care for Rural Lung and Head-and-Neck Cancer Patients
ABSTRACT: Improving the timeliness and quality of care for lung cancer (LC) and head and neck cancer (HNC) patients is of utmost importance because delays in treatment initiation a...
Dissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancer
PROJECT SUMMARY Pancreatic cancer is a major health issue in the US, with only 7% of patients surviving beyond 5-years and nearly all patients presenting with metastases. Identifyi...
The role of the macroenvironment in pancreatic cancer-induced cachexia
PROJECT SUMMARY: OVERALL The overall goal of this Program Project is to gain a better understanding of the underlying mechanisms that drive cachexia in cancer patients, especially...
Project 1 – IL-6/STAT3/NF-kB in Adipose-Muscle Crosstalk in the Pancreatic Cancer Macroenvironment
PROJECT SUMMARY: PROJECT 1 Cancer cachexia, or progressive weight loss featuring immunodysmetabolism, causes ~1/3 of cancer deaths. Loss of muscle mass reduces performance status,...
Project 2 NF-#B regulation in muscle wasting and pancreatic cancer-induced cachexia
PROJECT SUMMARY: PROJECT 2 Cachexia is a debilitating syndrome that results in severe, involuntary weight loss due to the depletion of skeletal muscle and adipose tissues. This syn...