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20,252 grants found
Showing 16,941 – 16,960 of 20,252 grants
Twist1 as a Target for Prevention and Treatment of Cutaneous Squamous Cell Carcinoma
PROJECT SUMMARY The overall goal of the proposed research is to understand the role of Twist1 in cutaneous squamous cell carcinoma (cSCC) and to develop novel approaches for target...
Vascularized tumor explants for drug testing
Project Abstract Our understanding of cancer progression or response to therapies would benefit from easily accessible, patient- specific assays that recapitulate the biology and a...
Enhancing the efficacy of androgen signaling inhibitors in prostate cancer
Title: Enhancing the efficacy of androgen signaling inhibitors in prostate cancer Abstract It has been documented that androgen receptor (AR) signaling remains to play a critical r...
Neoantigen-Targeted Vaccines in Combination with Immune Checkpoint Inhibitors for Pancreatic Cancer
PROJECT SUMMARY Immune checkpoint inhibitors (ICIs) provide durable clinical responses in about 20% of cancer patients, but have minimal effects in cancers lacking intra–tumoral T...
Diagnosis of Cancer in the Emergency Room - Explaining Persistent Disparities
PROJECT SUMMARY/ABSTRACT Cancer is a common diagnosis in the emergency department (ED) and by the time patients reach the ED, their cancer has often progressed to later stages. EDs...
UCSF Paul Calabresi K12 Career Development Program in Clinical Oncology
Project Summary/Abstract The goal of the UCSF Paul Calabresi Career Development Award for Clinical Oncology is to foster the development of the next generation of clinical scientis...
Elucidating the Roles of RNA m6A readers Y1 and Y2 in radiation-induced immunity and immunotherapy
Project Summary Cancer is a leading cause of death worldwide. Recent advancements in the use of immune checkpoint blockade have transformed oncology, and immunotherapy has extended...
Dissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancer
PROJECT SUMMARY Pancreatic cancer is a major health issue in the US, with only 7% of patients surviving beyond 5-years and nearly all patients presenting with metastases. Identifyi...
Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDA) is projected to become the 2nd leading cause of cancer-related deaths world-wide by 2030, largely due a lack of effe...
Function of Musashi-2 Methylation in Normal and Malignant Hematopoiesis
Project Abstract Acute myeloid leukemia (AML) is an aggressive, heterogeneous disease and is characterized by the expansion of immature myeloid progenitors and the inhibition of my...
Ovarian Inflammaging as a Mechanism for Ovarian Cancer
PROJECT SUMMARY High-grade serous ovarian carcinoma (HGSOC) is the most lethal cancer of the female reproductive system with less than 50% of patients surviving 5-years after diagn...
Characterizing the XRN1 exoribonuclease as a therapeutic target in non-small cell lung cancer
PROJECT SUMMARY/ABSTRACT Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide. The development of targeted molecular therapies that inhibit m...
Statistical methods for cancer mutational signatures
Project Summary Carcinogens and evolutionary pressures generate unique patterns in the types of somatic mutations observed in the DNA of cancer cells. Mutational signature analysis...
Infection-Associated Cancer Research Training Program in Mali
PROJECT SUMMARY The Northwestern University (NU) and Mali’s University of Sciences, Techniques, and Technologies of Bamako (USTTB)’s Infection-Associated Cancer (NM-IAC) Research T...
Integrative Functional Profiling of Tumor-Derived Extracellular Vesicles
PROJECT SUMMARY Clinical implementation of Precision Medicine faces major challenges in precision disease stratification and staging, determining optimal treatment, monitoring ther...
Dissecting the Role of Proteostasis in Anti-Androgen Resistant Prostate Cancer
PROJECT ABSTRACT In the United States, prostate cancer (PCa) is predicted to be the second leading cause of cancer related death in men in the United States in 2020. After initial...
Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma
Project Summary Given advances in screening and treatment, the number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) by 2030...
Adapting and implementing evidence-based breast cancer follow-up in primary care
PROJECT SUMMARY/ABSTRACT Breast cancer survivors are a growing population and their symptom burden is significant. Despite growing evidence on specific symptoms and risk management...
Improving the translational value of head and neck cancer patient-in-mouse models
Project Abstract: Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer. These models are established using pati...
Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancer
Project Summary Resistance to therapy is the major challenge for the treatment of pancreatic cancer. Despite recent successes in immune checkpoint therapy of several human cancer t...