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20,252 grants found
Showing 16,881 – 16,900 of 20,252 grants
Biomarkers of dasatinib response and resistance in T-cell acute lymphoblastic leukemia
Abstract Acute lymphoblastic leukemia (ALL) is the most common cancer in children, with T-cell ALL accounting for 15% of cases. T-ALL in children is associated with aggressive clin...
Adapting and implementing evidence-based breast cancer follow-up in primary care
PROJECT SUMMARY/ABSTRACT Breast cancer survivors are a growing population and their symptom burden is significant. Despite growing evidence on specific symptoms and risk management...
Metabolic Control and Anticancer Mechanism
ABSTRACT As a central controller of cancer growth and metabolism, mTORC1 pathway is commonly mutated and activated in human cancer, leading to uncontrolled growth. Cancer cells are...
Development of AMPK Inhibitors for the treatment of leukemia
PROJECT SUMMARY Despite advances in the treatment of acute myeloid leukemia (AML), only 20–30% of patients achieve long-term disease-free survival (DFS) and treatment options for r...
Real time colon histopathology by infrared spectroscopic imaging
Abstract Colorectal cancer (CRC) is one of the leading causes of death in the US. Active screening and early intervention in risky cancers can lead to good outcomes; however, a bot...
Elucidating the Roles of RNA m6A readers Y1 and Y2 in radiation-induced immunity and immunotherapy
Project Summary Cancer is a leading cause of death worldwide. Recent advancements in the use of immune checkpoint blockade have transformed oncology, and immunotherapy has extended...
Hexokinase 2 and cancer therapy
Cancer cells are metabolically different from normal matching cells, and this is manifested by the high rate of glucose metabolism in cancer cells. The high rate of glucose metabol...
Ethnicity and Lung Cancer Survival: A Test of the Hispanic Sociocultural Hypothesis
PROJECT SUMMARY/ABSTRACT As the leading cause of cancer death, lung cancer represents the most significant cancer-related public health challenge in the United States. Although low...
Statistical methods for cancer mutational signatures
Project Summary Carcinogens and evolutionary pressures generate unique patterns in the types of somatic mutations observed in the DNA of cancer cells. Mutational signature analysis...
The role of CEACAM1 in oncogenic B-cell receptor signaling and immunotherapy in mantle cell lymphoma
Abstract Mantle cell lymphoma (MCL) accounts for 6-8% of all non-Hodgkin lymphomas (NHLs). While substantial therapeutic advances have been achieved for other NHLs, MCL remains an...
Pentraxin-3 in the Pathogenesis and Management of Triple-Negative Breast Cancer
SUMMARY Background. Triple-negative breast cancers (TNBCs) present with advanced histological grade and aggressive clinical behavior. They are overwhelmingly unresponsive to conven...
The oncogenic functions of Neuropilin-1 in the glioblastoma tumor microenvironment
Abstract Glioblastoma (GB) is the most common primary tumor of the central nervous system (CNS) in adults. Despite aggressive surgery, radiation, and chemotherapy, median survival...
Persistent STAT5 signaling in polyfunctional CD4 T cells and its application in adoptive T cell therapy
Project summary/abstract Recent advances in adoptive T-cell therapy (ACT), especially CD19-targeting chimeric antigen receptor (CAR) T-cell therapy (CD19CART), have highlighted the...
Dissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancer
PROJECT SUMMARY Pancreatic cancer is a major health issue in the US, with only 7% of patients surviving beyond 5-years and nearly all patients presenting with metastases. Identifyi...
Dynamic prediction incorporating time-varying covariates for the onset of breast cancer
PROJECT SUMMARY Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options and poor survival. Approximately 12% to 17% of women w...
AN INTEGRATED PLATFORM FOR NOVEL PERSONALIZED LIVER CANCER THERAPEUTICS
SUMMARY Hepatocellular carcinoma (HCC) is a major health problem, with increasing mortality rates. In the US, HCC mortality is strongly affected by race/ethnicity and the highest m...
CONNECT: COmpreheNsive traiNing and Engagement in Cessation Treatment
PROJECT SUMMARY Adult smoking prevalence in the United States (US) is approximately 14% nationwide, yet significant disparities persist, including among adults with annual househol...
Decoding the Tissue of Origin of Cellular Damage from Cell-free DNA in Liquid Biopsies
ABSTRACT Liquid biopsy applications are rapidly emerging as a minimally invasive approach to collect system-wide representative analytes for genomic monitoring of physiologic and d...
Personalized Adoptive T-cell Therapy for AML
Abstract/Project Summary The development of strategies to expand and activate AML specific T cells is of critical importance. We have developed a personalized cancer vaccine in whi...
TASK ORDER 75N91021F00001 FOR SUPPORT SERVICES FOR DEVELOPING AND PROMOTING METHODS AND STANDARDS FOR CANCER REGISTRY OPERATIONS AND SURVEILLANCE DATA
The objective of this contract is to provide support to the North American Association of Central Cancer Registries (NAACCR) in order to make the National Cancer Institute’s (NCI)...