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20,252 grants found
Showing 16,841 – 16,860 of 20,252 grants
Epigenetically Engineered Mouse Model for Lung Cancer Therapy
PROJECT SUMMARY (Abstract) The importance of aberrant DNA methylation in cancer is clear. The fundamental role of DNA methylation in cancer initiation and progression, however, rem...
Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system
Chemotherapy-related cognitive impairment (CRCI, chemobrain), chemotherapy-induced peripheral neuropathy (CIPN) and gait changes are debilitating side-effects of cancer treatment w...
Leveraging Tumor Suppressor Inactivation for Osteosarcoma Therapy
PROJECT SUMMARY Osteosarcoma (OS) is the most common malignant bone tumor, found in the pediatric population and often leads to death due to tumor progression and metastasis. Despi...
Elucidating the role of DNAPKcs in chromosomal break end joining and clastogen resistance
SUMMARY. Kinase inhibitors targeting the catalytic subunit of the DNA-dependent protein kinase (DNAPKcs) are being developed to sensitize tumors to clastogenic (chromosomal-breakin...
Low Cost Tethered Capsule Endoscope with High-Resolution Digital Chromoscopy for Barrett's Screening
Abstract Esophageal cancer is the 6th leading cause of cancer death worldwide; rates of esophageal adenocarcinoma (EAC) haverisen exponentially over the past 4 decades. When EAC is...
MyGI Diet for Colorectal Cancer Prevention
PROJECT SUMMARY Despite the large body of research that has identified the impact of diet on cancer risk, little has been done to translate these findings to clinical settings. Her...
Diagnosis of Cancer in the Emergency Room - Explaining Persistent Disparities
PROJECT SUMMARY/ABSTRACT Cancer is a common diagnosis in the emergency department (ED) and by the time patients reach the ED, their cancer has often progressed to later stages. EDs...
Targeting cellular double-stranded RNA homeostasis in breast cancer
Summary/Abstract The immunologically inactive (cold) tumor is a major challenge for effective immunotherapies in many cancers, including breast cancer. Increasing evidence has demo...
Dissecting the Role of Proteostasis in Anti-Androgen Resistant Prostate Cancer
PROJECT ABSTRACT In the United States, prostate cancer (PCa) is predicted to be the second leading cause of cancer related death in men in the United States in 2020. After initial...
Writing to Heal: A Culturally Based Brief Expressive Writing Intervention for Chinese Immigrant Breast Cancer Survivors
Project Summary/Abstract The unavailability of culturally competent mental health care for Chinese immigrant breast cancer survivors and their unmet psychological needs characteriz...
Neural Niche in Promoting Brain Metastatic Tumor Progression
Project Summary Title: Neural Niche in Promoting Brain Metastasis Progression Metastatic progression at the brain is a multi-step, evolutionary process that is accomplished through...
Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma
Project Summary Given advances in screening and treatment, the number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) by 2030...
Integrative Functional Profiling of Tumor-Derived Extracellular Vesicles
PROJECT SUMMARY Clinical implementation of Precision Medicine faces major challenges in precision disease stratification and staging, determining optimal treatment, monitoring ther...
Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic Cancer
PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDA) is projected to become the 2nd leading cause of cancer-related deaths world-wide by 2030, largely due a lack of effe...
Neoantigen-Targeted Vaccines in Combination with Immune Checkpoint Inhibitors for Pancreatic Cancer
PROJECT SUMMARY Immune checkpoint inhibitors (ICIs) provide durable clinical responses in about 20% of cancer patients, but have minimal effects in cancers lacking intra–tumoral T...
Evaluation of treatment predictors reflecting beta-catenin activation in hepatocellular carcinoma
PROJECT SUMMARY/ABSTRACT Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide and its incidence is rising in both men and women in the United States. Ant...
Diversity Supplement to Adapting and implementing evidence-based breast cancer follow-up in primary care
Project Summary/Abstract Breast cancer survivors are a growing population and their symptom burden is significant. Despite growing evidence on specific symptoms and risk management...
NIH Diversity Supplement (R00-CA-256351)
PROJECT SUMMARY Ms. McKenzie Reese is an undergraduate researcher at Loyola Marymount University (LMU) seeking additional training, mentorship, and career development in psycho-onc...
Innate Immune Mechanisms Contributing to Cancer Growth in Obesity
Supplement Project Summary Obesity (body mass index ≥30 kg/m2), which affects at least one-third of the U.S. population, is more prevalent among African American and Hispanic popul...
VDX-111: A novel targeted therapeutic for triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancers (TNBC) represent a significant challenge to basic scientists studying the molecular underpinnings of the disease and to patients and...