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Mechanisms of DNMT3B-mediated DNA Methylation Maintenance
PROJECT SUMMARY DNA methylation (5mC) is catalyzed by three DNA methyltransferases (DNMTs): DNMT1, DNMT3A, and DNMT3B.DNMT3A and 3B are often referred to as de novo DNMTs, function...
Hexokinase 2 and cancer therapy
Cancer cells are metabolically different from normal matching cells, and this is manifested by the high rate of glucose metabolism in cancer cells.The high rate of glucose metaboli...
Development of AMPK Inhibitors for the treatment of leukemia
PROJECT SUMMARY Despite advances in the treatment of acute myeloid leukemia (AML), only 20?30% of patients achieve long-term disease-free survival (DFS) and treatment options for r...
NCI Pediatric In Vivo Testing Program: Neuroblastoma
Project Summary Children with disseminated neuroblastoma have a very high risk of treatment failure and death despite receiving intensified chemotherapy, radiation therapy and immu...
Chromosomal Instability as a Marker and Mechanism of Radiation Response
ABSTRACT Human Papilloma Virus (HPV) causes nearly 5% of all cancers worldwide and is implicated in 95% of cervical and 70% of oropharyngeal cancers (OPC). Curative platinum-based...
A pro-metastatic secretory pathway activated by p53 loss in lung cancer
Cancer cells are embedded in a protective and nourishing “niche”, an environment that cancer cells create by secreting proteins into their surroundings. Because cancer cells depend...
Characterizing Chromatin Remodeling Mechanisms of Chemo-Sensitivity and Resistance in Pediatric Solid Tumors
PROJECT SUMMARY Despite the known roles of chromatin remodeling complexes in driving more than 20% of human cancer, the role of chromatin remodeling complexes in conferring therape...
Metabolite sensing through the HAT1 acetyltransferase as an anti-cancer target
PROJECT SUMMARY/ABSTRACT This is an application for a K08 for Dr. Joshua Gruber, an Instructor of Medicine at Stanford University. Dr. Gruber wishes to establish himself as a clini...
PSMA’s enzymatic activity as new target for Prostate Cancer diagnosis and therapy
SUMMARY. The problem: Hormone therapy remains the standard treatment for prostate cancer (PC). While most patients initially respond to therapy, they will ultimately progress to le...
Prognostic and Therapeutic Implications of IFNAR1 Signaling on CAR T Cell Therapy for Cancer
Adoptive cellular therapy (ACT) has revolutionized the treatment of certain malignancies and responses in refractory B cell tumors treated with chimeric antibody receptor (CAR)-exp...
Using dietary glutamine supplementation for melanoma prevention and targeted therapy
PROJECT SUMMARY Despite recent advances in cancer metabolism, whether and how nutritional interventions affect tumor development, metastasis and therapeutic response are still poor...
Pediatric Preclinical In Vivo Testing Center for Pediatric Sarcoma and Other Solid Tumors
ABSTRACT With recent enactment of the Research to Accelerate Cures and Equity (RACE) for Children Act, there is a growing impetus to identify pediatric indications for molecularly...
Rational in situ programming of cancer vaccine-responding T-cell clones
Project Summary Currently no method exists that would allow physicians to rapidly and reliably establish T-cell immunity against tumor antigens. Bioinformatics tools can predict an...
Plk1 as a prognostic biomarker for prostate cancer
Title: Plk1 as a prognostic biomarker for prostate cancer Abstract Because androgen receptor (AR) signaling is essential for development of prostate cancer (PCa), including castrat...
Impact of Host NF-kB Signaling in Radiation Therapy
PROJECT SUMMARY / ABSTRACT Investigation of cytoplasmic-to-nuclear (C→N) NF-κB signaling pathways induced by various cell surface receptors has significantly expanded the knowledge...
Germline Structural Variant Identification and Functional Determination in Childhood Cancer
Abstract A few germline pathogenic structural variants (SV) have been identified in cancer predisposition syndromes, e.g., MSH2 inversion in Lynch syndrome. The advent of short-rea...
The Role of BCL2 Mediated Calcium Signaling in Leukemia Stem Cell Metabolism
PROJECT SUMMARY The objective of this study is to define the molecular mechanisms that control survival of malignant stem cells in acute myeloid leukemia (AML). Acute myeloid leuke...
AN INTEGRATED PLATFORM FOR NOVEL PERSONALIZED LIVER CANCER THERAPEUTICS
SUMMARY Liver cancer is the fourth leading cause of cancer related mortality worldwide. Currently, in addition to emerging immune checkpoint inhibitors, a small number of structura...
Precision magnetic hyperthermia by integrating magnetic particle imaging
Precision magnetic hyperthermia by integrating magnetic particle imaging Magnetic activation of magnetic iron oxide nanoparticles (MIONPs) offers considerable potential for numerou...
Androgen receptor pathway inhibition through targeting PARP-2 in castration-resistant prostate cancer
ABSTRACT Androgen receptor (AR) is ligand-activated transcription factor and a driver of prostate cancer (PCa). Understanding the molecular mechanisms of AR-mediated transcription...