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20,252 grants found
Showing 16,801 – 16,820 of 20,252 grants
Characterizing the XRN1 exoribonuclease as a therapeutic target in non-small cell lung cancer
PROJECT SUMMARY/ABSTRACT Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide.The development of targeted molecular therapies that inhibit mu...
Prognostic and Therapeutic Implications of IFNAR1 Signaling on CAR T Cell Therapy for Cancer
Adoptive cellular therapy (ACT) has revolutionized the treatment of certain malignancies and responses in refractory B cell tumors treated with chimeric antibody receptor (CAR)-exp...
Improving pediatric brain tumor treatments using FLASH radiotherapy
PROJECT SUMMARY Our R01 application entitled, ?Improving pediatric brain tumor treatments using FLASH radiotherapy? is focused on translating a novel irradiation modality into clin...
Epigenetically Engineered Mouse Model for Lung Cancer Therapy
PROJECT SUMMARY (Abstract) The importance of aberrant DNA methylation in cancer is clear. The fundamental role of DNA methylation in cancer initiation and progression, however, rem...
Determine the Microphthalmia Transcription Factor (MITF)-regulated cell rewiring mechanisms in lethal prostate cancer
Once prostate cancer progresses to an advanced castration resistant stage it becomes an incurable deadly disease.To date the understanding of the intrinsic tumor cell biology proce...
Development of Lasso Peptides as Potent Endothelin Receptor B Antagonists for Immuno-oncology
Abstract.Immunotherapy has rapidly emerged as an effective treatment option for a growing number of cancers, yet the vast potential of this approach is often limited by low patient...
Remote monitoring of cardiac function in childhood cancer survivors
Abstract Cardiovascular complications are a leading cause of morbidity and mortality in survivors of childhood cancer.These survivors have a greater than four-fold risk of developi...
The role of Epstein Barr Virus and Human Papilloma Virus Co-infection in Conjunctival Squamous Cell Carcinoma.
PROJECT SUMMARY Conjunctival Squamous Cell Carcinoma (SCC) is a malignant disease of the eyes, classified under ocular surface squamous neoplasia (OSSN) (Gichuhi et al. 2015).Incid...
Precision magnetic hyperthermia by integrating magnetic particle imaging
Precision magnetic hyperthermia by integrating magnetic particle imaging Magnetic activation of magnetic iron oxide nanoparticles (MIONPs) offers considerable potential for numerou...
Pentraxin-3 in the Pathogenesis and Management of Triple-Negative Breast Cancer
SUMMARY Background. Triple-negative breast cancers (TNBCs) present with advanced histological grade and aggressive clinical behavior.They are overwhelmingly unresponsive to convent...
Mechanisms of Esophageal Carcinogenesis
PROJECT SUMMARY - OVERALL Esophageal cancer is common worldwide. There are two major subtypes: esophageal squamous cell cancer (ESCC) and esophageal adenocarcinoma (EAC).Precursor...
Discovery and verification of methylated circulating tumor DNA markers for the detection of colorectal cancer in subjects under 50 years of age
Abstract In recent years, the incidence of colorectal cancer (CRC) under the age of 50-years has increased significantly and population-based screening is currently not offered to...
Plk1 as a prognostic biomarker for prostate cancer
Title: Plk1 as a prognostic biomarker for prostate cancer Abstract Because androgen receptor (AR) signaling is essential for development of prostate cancer (PCa), including castrat...
The role of Interleukin 17RB signaling in colorectal cancer progression
Despite important advances in detection, surgery and chemotherapy, colorectal cancer (CRC) is the second cause of cancer death in the U.S.Most of these deaths are due to cancer pro...
In vivo characterization of keratinocytes in the melanoma microenvironment
PROJECT SUMMARY Melanoma is the most lethal of skin cancers, with progression to local invasion and metastasis leading to poor patient outcomes, highlighting the need for better un...
Impact of Host NF-kB Signaling in Radiation Therapy
PROJECT SUMMARY / ABSTRACT Investigation of cytoplasmic-to-nuclear (C?N) NF-?B signaling pathways induced by various cell surface receptors has significantly expanded the knowledge...
AN INTEGRATED PLATFORM FOR NOVEL PERSONALIZED LIVER CANCER THERAPEUTICS
SUMMARY Liver cancer is the fourth leading cause of cancer related mortality worldwide.Currently, in addition to emerging immune checkpoint inhibitors, a small number of structural...
Role and Mechanisms of VAV1 alterations in Peripheral T-cell Lymphomas
Project Summary/Abstract Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous and poorly understood pathological group of non-Hodgkin lymphomas associated with poor progno...
Leveraging Tumor Suppressor Inactivation for Osteosarcoma Therapy
PROJECT SUMMARY Osteosarcoma (OS) is the most common malignant bone tumor, found in the pediatric population and often leads to death due to tumor progression and metastasis.Despit...
A DUAL ROLE OF INTEGRIN ALPHA-3 IN BREAST CANCER CNS METASTASIS & CHEMORESISTANCE
ABSTRACT Integrins serve a multifaceted role in cancer progression by regulating cell migration as well as mediating signaling pathways important in proliferation and chemoresistan...