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20,252 grants found
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Dynamic µOCT for cellular tissue phenotyping
Phenotyping cells and tissue is a critical function that spans basic science to clinical diagnosis. Yet, established methods for phenotyping cells in tissue are static, are evaluat...
Investigating the structure and function of the human centromere and kinetochore
Project Summary Accurate segregation of chromosomes during cell division is one of the most fundamental requirements in biology. Without proper chromosomal segregation, genetic inf...
Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer
PROJECT SUMMARY Tumor heterogeneity is the main cause of resistance to current chemotherapy drugs as well as metastasis development, leading to patients' death. Within the sam...
Elucidating transcriptomic and functional heterogeneity of microglia in low-grade glioma and glioma-associated epilepsy.
PROJECT SUMMARY/ABSTRACT Low-grade glioma (LGG) is a disease that, despite the modern standard of care, frequently recurs or progresses to high- grade glioma, such as glioblastoma...
Hyperpolarized C-13 MRI Techniques to Monitor Radiation Therapy Response in Prostate Cancer Patients
Project Summary/Abstract The goal of this research project is to investigate new 3D advanced hyperpolarized (HP) 13C-pyruvate MRI techniques to quantitatively monitor metabolic cha...
State-of-the-Art Synthesis of Interventions to Promote Quit Intentions and Smoking Cessation
Project Summary Most people who smoke have no intention of quitting in the next 6 months or beyond, which begs critical questions of the field of cancer prevention and control: How...
Novel DNA damage response therapeutics targeting replication protein A
Novel DNA damage response therapeutics targeting replication protein A Abstract The DNA damage response (DDR) is now considered a tractable pathway to target for cancer therapy. Th...
Platelet PI3Kbeta regulation of metastasis
Abstract Metastasis is the primary cause of morbidity and mortality among patients with solid tumors. Platelets interact with tumor cells upon their entry into the vasculature and...
Infection-Associated Cancer Research Training Program in Mali
PROJECT SUMMARY The Northwestern University (NU) and Mali’s University of Sciences, Techniques, and Technologies of Bamako (USTTB)’s Infection-Associated Cancer (NM-IAC) Research T...
Androgen Signaling in CaP with loss of MAP3K7 and CHD1
Prostate cancer is characterized by large genomic rearrangements and deletions. We show that the genes CHD1 and MAP3K7 are co-deleted in ERG translocation negative prostate cancer....
Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma
Project Summary Given advances in screening and treatment, the number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) by 2030...
Mechanistically Dissecting Glycolysis Regulation by Lactate and Its Therapeutic Potential in Cancer
PROJECT SUMMARY/ABSTRACT Glucose is an essential fuel for cancer cell proliferation in serving both as a substrate for ATP production and as an irreplaceable carbon source for biom...
Do Tumor-Immune Interactions Prime Systemic Tolerance of Triple-Negative Breast Cancer Brain Metastases?
PROJECT ABSTRACT/SUMMARY It is widely estimated that 90% of cancer-related deaths are caused by metastasis.This statistic underscores our inability to manage cancer once it dissemi...
The RNA structural code underlying pathological regulation of RNA splicing in metastasis
PROJECT SUMMARY Widespread aberrant splicing is now considered a hallmark of cancer, and many of the resulting transcript isoforms have been functionally implicated in tumorigenesi...
Writing to Heal: A Culturally Based Brief Expressive Writing Intervention for Chinese Immigrant Breast Cancer Survivors
Project Summary/Abstract The unavailability of culturally competent mental health care for Chinese immigrant breast cancer survivors and their unmet psychological needs characteriz...
Investigating the structure and function of the human centromere and kinetochore
Project Summary Accurate segregation of chromosomes during cell division is one of the most fundamental requirements in biology.Without proper chromosomal segregation, genetic info...
Understanding the role of TWIST1 in colorectal cancer progression and metastasis
Project Summary: Although almost all colorectal cancer (CRC) mortality is due to metastasis, there are currently no drugs to prevent or halt metastasis.A better understanding of th...
Assisted Reproductive Technology Use After Adolescent and Young Adult Cancer in North Carolina
PROJECT SUMMARY/ABSTRACT Improving cancer survival trends among adolescent and young adults (AYAs) present an urgent need to address their unique survivorship concerns and strive t...
Decoding the Tissue of Origin of Cellular Damage from Cell-free DNA in Liquid Biopsies
ABSTRACT Liquid biopsy applications are rapidly emerging as a minimally invasive approach to collect system-wide representative analytes for genomic monitoring of physiologic and d...
Integrated ligand and target discovery by chemical proteomics for glioblastoma treatment.
PROJECT SUMMARY The epidermal growth factor (EGFR) oncogene is amplified and drives tumor growth in 55% of adult glioblastomas (GBMs).However, EGFR inhibitors have failed to demons...