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20,252 grants found
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Targeting circRNA translation in glioblastoma
Project Summary Glioblastomas are highly malignant and invasive, making these neoplasms extremely difficult to surgically resect and these properties often result in tumors which a...
NPC1 as a novel therapeutic target in ccRCC
PROJECT SUMMARY/ABSTRACT Renal cell carcinoma (RCC) accounts for more than 430,000 cases of cancer worldwide and about 180,000 cancer-related deaths each year. Clear cell RCC (ccRC...
Linking lifestyles with tumor immune profiles to identify strategies for improving breast cancer outcomes
A developing body of preclinical evidence suggests that the integrity and composition of the tumor immune microenvironment (TIME) is highly plastic and is modulated by host lifesty...
Role of JMJD4 in Breast Cancer
PROJECT SUMMARY – ROLE OF JMJD4 IN BREAST CANCER In 2023, nearly 43,000 women will die from breast cancer in the US, indicating the urgent need for better therapies. A more compreh...
Cellular and Molecular Mechanisms of Arsenic-Induced Urothelial Bladder Cancer
ABSTRACT Urothelial bladder cancer represents a significant global public health burden, accounting for some 200,000 deaths each year. Among the many environmental risk factors for...
Targeting Oxidized PTP1B for Anticancer Drug Discovery
PROJECT SUMMARY PTP1B, a non-receptor–type oncogenic PTP, also known as PTPN1, is involved in growth factor signaling. The PTP1B gene is frequently amplified in cancers and correla...
Explainable AI-Based Multi-Omics Analysis of Lung Cancer Health Disparity
PROJECT SUMMARY The proposed research aims to understand and discover the disparity of lung cancer development between African Americans and European Americans, considering race an...
Identifying germline pathogenic variants in familial lung cancer among African-Americans
ABSTRACT Lung cancer (LC) is the third most common cancer in the U.S. with African Americans (AAs) having the highest incidence and mortality. While previous linkage, admixture, ex...
Human brain organoids as a novel platform for evaluating effects of radiation in the CNS and screening for radiation mitigators
PROJECT SUMMARY Radiation therapy (RT) is a standard-of-care oncological treatment for the central nervous system (CNS). However, during cranial RT, normal brain tissue adjacent to...
Neuroprotection for chemotherapy induced peripheral neuropathy
Chemotherapy induced peripheral neuropathy (CIPN) poses a major clinical problem due to its oftentimes dose- limiting side effects associated with many commonly employed anti-cance...
CD28-KITv CAR T cells with PD-1 dominant negative receptor
PROJECT ABSTRACT The success of chimeric antigen receptor (CAR) T-cell therapy in solid tumors requires antigen targets with no on-target, off-tumor toxicity, effective tumor infil...
Interstitial Photodynamic Therapy Following Palliative Radiotherapy for Patients with Inoperable Malignant Central Airway Obstruction
Summary Patients with extrabronchial tumors that induce malignant central airway obstruction (MCAO) face significant morbidity and only 1-7 months median overall survival. An estim...
Interrogating MRCK Protein Kinases in Ovarian Cancer
The majority of recurrent ovarian cancers spread to the peritoneal cavity in the form of ascites, where tumor cells grow as spheroids, and metastasize to other organs causing morbi...
Brain-Restricted Kinase Inhibition with Binary Pharmacology
Glioblastoma (GBM), the most common primary malignant brain cancer, remains among the most lethal of cancers. The mechanistic target of rapamycin (mTOR) is dysregulated prominently...
Combining CDK7 and MUC1-C inhibition to target different subtypes of small cell lung cancer
Summary Small cell lung cancer (SCLC) is a highly aggressive and lethal disease, accounting for about 15% of all lung cancers. SCLC patients often initially respond to chemotherapy...
Molecular and cellular mechanisms of neuronal damage caused by anticancer therapies
Project Summary Cancer is a terrifying diagnosis, especially in a child, yet thanks to great advances in treatment, survival rates have increased steeply. For CNS/brain tumors and...
Expanding the cancer paralog genetic interaction map to enable precision oncology
PROJECT SUMMARY/ABSTRACT Recent advances in targeted therapies have prolonged the survival of non-small cell lung cancer patients. However, lung cancer still remains the leading ca...
A Topical Plasmid-based Approach to Cervical Cancer Screening
PROJECT SUMMARY/ABSTRACT The specific objective of this proposal is to demonstrate proof-of-concept for a novel screening approach for cervical cancer (CC) using a topically applie...
Elucidating the role of DNAPKcs in chromosomal break end joining and clastogen
SUMMARY Kinase inhibitors targeting the catalytic subunit of the DNA-dependent protein kinase (DNAPKcs) are being developed to sensitize tumors to clastogenic (chromosomal-breaking...
Dietary fatty acids drive pancreatic cancer development
PROJECT SUMMARY/ABSTRACT Despite significant advances in cancer care, pancreatic ductal adenocarcinoma (PDAC) remains the third leading cause of cancer death in the United States w...